<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28932

Description Mediator complex subunit 14
SequenceMAPVQIGTDGQLVPFGGPVVSGPQANPSGAPAAQGVRLSLLIEYLLCRTYHEITVLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLRQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLDILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEERYVPAKYLTLSVWNQQVLGKKTGTAPVHKVTIKIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARAHQKLQELKAILKTSNPSDNSFIETALPTLVVPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKTINEDMKRIISWLQQLKFWLGEQRCRQSVKHLPTVCTDVLHLSNSTSHPVGSLSKHKLFIKLTRLPQCYIVVEMLDVPCNPTALQYKYSFLSVSQLEGEDGLLCAQLLQHFKPNLEHLVQDAIVHKELRSGTKRKSSGDQCDTEPKKPKRSGEMCAFNKELAHLVAICDTNMPFVSLRTELSNMEIPSQGVQVEVDGSGHAIRLLKIPPCKGVGEETRRALERSLLDCTFRLQGRNNRTWVAELVLASCPLNSTNSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNAISQLYQCVLNFSCVLPEMPSYLNLFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSSSQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVLQLLQVLYDTLAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGGDMDSLINQLQAPQQPQSMRGAAGGVYPPLTSPPPNYHTNVTPSPSMMPTQSPGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGSQVMPTSMPPPRKLPQRPWAASIPTILTHSALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQELTIVNSNEPGVIMFKTDVLKCRVALNPKNYQTLQLKVTPENTGPWSQEELQVLERFFETRVAGPPFKFNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRIPVPQDPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPPRQGECTIFASVHDLMVNLTFPPGTR
Length1372
PositionTail
OrganismOryzias latipes (Japanese rice fish) (Japanese killifish)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias.
Aromaticity0.06
Grand average of hydropathy-0.134
Instability index50.19
Isoelectric point8.60
Molecular weight152689.23
Publications
PubMed=17554307

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
blood vessel morphogenesis	GO:0048514	IEA:Ensembl
embryonic viscerocranium morphogenesis	GO:0048703	IEA:Ensembl
neural crest cell differentiation	GO:0014033	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
stem cell population maintenance	GO:0019827	IEA:Ensembl
ventricular system development	GO:0021591	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28932
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     462.68|     182|     230|     516|     745|       1
---------------------------------------------------------------------------
  516-  575 ( 2.44/15.33)	.............................................................................................................................................................................................................PVGslskhklfikltRLPQCyivveMLDVPCN.PTALQYKYSFLSVSQLEGEDGLLCAQLL
  576-  802 (260.50/259.23)	QHFkpnleHLvqdaivhkELrsGTKRKSSG.DQC.........DTEPKKPKRSGEMCAFNKELAHLVAICD.TNMPFVSLrTELSNMeiPSQGVQVEVDGSGHaIRL.......LKIpPCKGVGEETRRALERSLLDCTFRLQG....RNNRTWVAELVlascplnstNSKEQASTRHVYlTYENPLSePVGgrkvvemflndwnAIS............QLYQC.....VLNFSCVlPEMPSYLNLFSEVRLYNYRKLVLCYGTT
  816-  976 (199.74/130.92)	QRF.....HL........AL..GTVGPNSGcSNChniilhqlqEMFNKNPNVLQLLQVLYDTLAPLNAINKlPTVPMLGL.TQRTNT..AYQCFSILPQSPTH.IRLafrnmycIDI.YCRSRGVVAIRDGAYSLFDNTKIVEGfypaPGLKTFLNMFV.........DSNQDARRRSVN.EDDNPPS.PVG..........................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.53|      58|     149|     282|     343|       2
---------------------------------------------------------------------------
  282-  343 (94.15/72.72)	CLHSFCLSLQLEvLHSQTL..MLI...RERWGDLvqeERYVPAKYLTLSVWNQQV...LGKKTGTAPVHK
  433-  498 (90.37/58.29)	CGRSECLHIFVD.LHSGMFqpMLYgldQSMLDDI...EKTINEDMKRIISWLQQLkfwLGEQRCRQSVKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.26|      28|      30|    1018|    1045|       3
---------------------------------------------------------------------------
  989- 1009 (23.62/ 7.26)	...........P.QQPQSMRgAAGGVYPPLTSP
 1018- 1045 (52.91/25.40)	TPSPS....MMPTQSPGNIH.ASGSPSGALRAP
 1051- 1082 (43.73/19.71)	TPSPSslgiAMGQTSFASPH.GSQVMPTSMPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     273.45|      90|     960|     131|     240|       4
---------------------------------------------------------------------------
  136-  240 (128.28/92.28)	LPSfAIPFAIDVLtTGSYprlpTCirdkiippDPITKAEKQTTL.RQLNQILRHRL..VTTDLPPQLA.NLTVANGRVKFRVEGEFEATLTVMGDDPDiPWRLLKLDIL
 1108- 1201 (145.16/64.44)	LPS.PTPCLVPGL.AGSY....LC........SPLERFLGSVIMrRHLQRIIQQELtiVNSNEPGVIMfKTDVLKCRVALNPKNYQTLQLKVTPENTG.PWSQEELQVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28932 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPVGGDMDSLINQLQAPQQPQSMRGAAGGVYPPLTSPPPNYHTNVTPSPSMMPTQSPGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGSQVMPTSMPPPRKLPQRPWA
957
1091










Molecular Recognition Features






MoRF SequenceStartStop




NANANA