Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MASVDFRDNLLGISWVDSSWVPILNPGNVLDYFSERSNPFYERSCNNEVVKMQRLSLEHLNQMVGVEYILLHAQEPILYIIRKQQRQSPTQVVPLADFYIIAGVVYQAPDLGTVISSRTLSAVHGIQSAFDEAMSYCRYHPSKGYWWQFKDQEEKEKAKPKSKKKEELSSLFQRHRVDTLLMDLRSKFPPTFYQPKPGDKPIPVEVKKEPEAPAETVKQEERESAAKTSAPTPSSKPPPEKRARLQ |
Length | 246 |
Position | Head |
Organism | Oryzias latipes (Japanese rice fish) (Japanese killifish) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.640 |
Instability index | 55.04 |
Isoelectric point | 8.68 |
Molecular weight | 28235.87 |
Publications | PubMed=17554307 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 PIRNR:PIRNR023869 |
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coactivator activity GO:0003713 IBA:GO_Central |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP28929 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 100.73| 31| 51| 139| 170| 1 --------------------------------------------------------------------------- 139- 170 (50.56/31.74) YHPSKGYwWQFKDQEEKEKAKP.KSKKKEELSS 193- 224 (50.17/26.23) YQPKPGD.KPIPVEVKKEPEAPaETVKQEERES --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IPVEVKKEPEAPAETVKQEERESAAKTS 2) SSKPPPEKRARLQ 3) YWWQFK | 202 234 145 | 229 246 150 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab