<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28928

Description Cyclin-dependent kinase 8
SequenceMDYDFKLKLTGERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPLQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIRRITSEQAMQDPYFFEEPLPTSDVFAGCQIPYPKREFLTEEEPEDKADKKNQQQQQGNNHTNGAGHTGNPENSHAQGPPLKKVRVVPPTTTSGGLIIPPDYQRQNQHAAYQNPGPSTSLPQSSMGYSSTSQQPPQYSQHPRY
Length415
PositionKinase
OrganismOryzias latipes (Japanese rice fish) (Japanese killifish)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias.
Aromaticity0.09
Grand average of hydropathy-0.759
Instability index41.39
Isoelectric point9.13
Molecular weight47731.93
Publications
PubMed=17554307

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28928
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.20|      26|      34|     347|     380|       1
---------------------------------------------------------------------------
  349-  380 (40.23/38.56)	QGP.PLKKvrvVPPTTT..SGGLIIPPDYqrqNQH
  384-  412 (40.97/18.60)	QNPgPSTS...LPQSSMgySSTSQQPPQY...SQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.06|      30|      35|     135|     165|       2
---------------------------------------------------------------------------
  135-  165 (52.24/41.25)	ILD.GIHYLHaNWVLH..RDLKPANILVMGEGPE
  171-  203 (45.82/31.02)	IADmGFARLF.NSPLKplADLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.93|      35|      40|     222|     261|       3
---------------------------------------------------------------------------
  222-  261 (51.64/40.60)	IKKMpehsTLMKDFRRNTYTNCSLIKYMEKHKVkPDSKAF
  264-  298 (61.29/33.88)	LQKL....LTMDPIRRITSEQAMQDPYFFEEPL.PTSDVF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28928 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLTEEEPEDKADKKNQQQQQGNNHTNGAGHTGNPENSHAQGPPLKKVRVVPPTTTSGGLIIPPDYQRQNQHAAYQNPGPSTSLPQSSMGYSSTSQQPPQYSQHPRY
305
415










Molecular Recognition Features






MoRF SequenceStartStop




1) GLIIPPDYQRQ
367
377