<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28927

Description Cyclin-dependent kinase 8
SequenceMDYDFKLKLTGERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPLQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIRRITSEQAMQDPYFFEEPLPTSDVFAGCQIPYPKREFLTEEEPEDKADKKNQQQQQGNNHTNGAGHTGNPENSHAQGPPLKKVRVVPPTTTSGGLIIPPDYQRQNQHAAYQNPGPSTSLPQSSMGYSSTSQQPPQYSQHPRY
Length463
PositionKinase
OrganismOryzias latipes (Japanese rice fish) (Japanese killifish)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias.
Aromaticity0.10
Grand average of hydropathy-0.693
Instability index40.40
Isoelectric point8.73
Molecular weight53304.20
Publications
PubMed=17554307

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28927
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.20|      26|      35|     395|     428|       1
---------------------------------------------------------------------------
  397-  428 (40.23/45.17)	QGP.PLKKvrvVPPTTT..SGGLIIPPDYqrqNQH
  432-  460 (40.97/21.70)	QNPgPSTS...LPQSSMgySSTSQQPPQY...SQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.06|      30|      35|     135|     165|       2
---------------------------------------------------------------------------
  135-  165 (52.24/39.75)	ILD.GIHYLHaNWVLH..RDLKPANILVMGEGPE
  171-  203 (45.82/29.83)	IADmGFARLF.NSPLKplADLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.99|      54|      87|     209|     265|       3
---------------------------------------------------------------------------
  209-  265 (86.71/78.55)	RHYTKAiDIWAIGcIFAELLTSEPIFHCRQEDiKTSNPYHHDQ.L..DRIFNVMGFPADK
  299-  355 (88.28/63.89)	KHKVKP.DSKAFH.LLQKLLTMDPIRRITSEQ.AMQDPYFFEEpLptSDVFAGCQIPYPK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28927 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLTEEEPEDKADKKNQQQQQGNNHTNGAGHTGNPENSHAQGPPLKKVRVVPPTTTSGGLIIPPDYQRQNQHAAYQNPGPSTSLPQSSMGYSSTSQQPPQYSQHPRY
353
463










Molecular Recognition Features






MoRF SequenceStartStop




1) GLIIPPDYQRQ
2) QYSQH
415
456
425
460