Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSLLLRLHAKHNASRPWQETCKVVQETHDIYIFFFSVSSLSSMTDRLESIARQNMLGSHLSPTGTECYITSDMFYVEVQLDSNGQLVDVKVAHQGENPTSCPELIQHLREKKFEEFSKHLKGLVDLYKLPGDNKLKTKMYIALQSLELDLAKMMHMFRLATNANTVETILHGSVGLLTPRSGGNLVTLQCYVSPYDIFQEGSGTQLNLTDSNVPRSLGVSVSVTIEGTSAVYKLPIAPLITGSHPVDNKGTPAFSTVTNSNCVDLPACFFLKMNRPMPFSTAFIKRMSNTAPSLSPLYQLIVQSQLQLLEEGSSLPAPSHNMHFYSILPDQQHCYFLNGNAPIQDSHSLQGAMVSKIPFRHPAHVPLLLDIIRHQAAYNTLIGSCVRQKSIKEDSAALLQFEVCPLTDSSFGVSFQHPVNESLVCVVMEVIDSRQVSCKLYKGQSDALICTDDFITKVVQRCMSIPVTMRAIRRKAETIQADTPALMLIAQTVETMVKNNLQSSGSPTYNMACPTSGAASQQQLLQQQGQGHTDNYNKVTQNPILTGLLQITGNVGSSPSSQNAPPPHQTPPPTSSPASNTKNHPMLMNLLKDNPTQDFAALYGSGTIERQNSSSCSPRTDSMAGASGSCGGSGGLSMKSQQSSMPQQQQHHPVSHEDDFHRELFSMDVDASQNSIFDVNLAGDGLDTPHSITPAPSQCGTPPPGSNMPYSQSHIQPQQPPGTVPPRMVRLSSSDSIGPDITEILQDLPEQPGKGSSESHGQHPMGSGGDDVGPLGTPIRDSSSSGQGSAVFDSGDIFNTNSNENPFTDTDLIPTPPDPIQDSDCSSSSFFHDPPDFSPEHSFTQNFFENCSESPDGVMDMVKGFGSQQNTPSGTPQNPTPHGQNTPEPSLKDPFDMGIVFGGNSGSGKPLLGHAPDLGDTHGGGSQSPLMMGLGAACSDFKSAEPKVKQQQGLVRAKEDNGASGGSNSGMGMGTSSTEGKQVKRSRTPSSEGKSKEKPPKRKKVDPDGKSPSHSSGGRPYTPPSGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTITGGKTSSHSGYTSSSSATSSSGGTGSTSSKSHHSHSSSSGKIKSKESSLSQGNNSKPGGAVGGSGQSQSKGSSQGVGKPGSSPITKHGFSGPGGAGSGNKIKPQGGKPPGSLINPNVKPNISPSHSRSSGSGDKLSSPMKMQQSQVPGTPPSSKAKSPMGSGGSSSGGSKSSSGGGQSSQKPIGGSSSSTASSSSSSSSSSSGSMSFSGGSQSQYVGGGGGSGGAGGSGGGTGQNNSNNPNAKGKSPSRNKKPSLTAVIDKLKSVGGGGVGEDGCDVGPPVGGAGSGAPPGGSGNVSSGPSNVGSTKHTSSSQNVEYKREKSDKEAKAKVSVSGGNSGEKKTMDSKAGGVGGTTLAKIIISKPDGGSPSIKAKVTLQKAGEGSSDSIRPQISSLKASPLFSGSTPKHDRSSPSHSRSPAYTPLNPDSESESGSSSVAEKSHQNSPSSDDDQTMRPLPPQDYMSSIPLGSGEKHKKHKKEKKKQKEKERERDRDRERDREKEKKKSSLSMGLSSHPMKADSWSRSPISASDSSLSMLSSDRPSRSSPMYMRNEEDELMDSALTGKFDPN |
Length | 1627 |
Position | Middle |
Organism | Oryzias latipes (Japanese rice fish) (Japanese killifish) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.673 |
Instability index | 59.05 |
Isoelectric point | 8.65 |
Molecular weight | 170263.91 |
Publications | PubMed=17554307 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP28926 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 1159.80| 149| 163| 962| 1124| 2 --------------------------------------------------------------------------- 503- 658 (154.34/30.40) ..SSGSPT.......yNMACPTSG.............A..............ASQQ......QLLQQQGQ..GHTDN...YNKVTQN.........PiltgllqiTGN..............VGS.SPSSQN...ApppH.Q..TP........PPT....SSPasntknhpmlmnllkdnPT..........QDFA..AL.....YGSGTIERQNSSSCS...................PRTDSmAGASGSC.....GGSGGL...S............MKSQQSSMPQQQ.......QHHP...VSHED 668- 795 (145.59/28.26) DVDASQNS........IFDVNLAG............................DGLDTPH..SITP.APSQ..CGTPP...P..........................................GSNMPYSQS.hiQ...P.Q..QP........PGT....VPP.................RMvrlsssdsigPDITeiLQ....dLPE...QPGKGSSES..................hGQHPM.GSGGDDV.....GPLGTPI.......RDSSSSGQ.......................GSAVFDSG 799- 960 (175.20/35.50) NTNSNENP........FTDTDLIP.............T..............PPDPIQD..SDC.SSSSF..FHDPPdfsPEHSFTQnffencsesP........DG........vmdmvkgFGSQQNTPSG...T...P.QnpTP........HGQ....NTP.................E...........PSLK..DP.....FDMGIVFGGNSGSGK...................PLLGH.APDLGDT.....HGGGSQSP.LM..MGLGAACSDFKSAEPKVKQ...........QQGLVRAKED 962- 1124 (247.00/53.04) GASGGSNS........GMGMGTSS.............T..............EGKQVKR..SRTPSSEGK..SKEKP...PKRKKVD.........P........DGKspshssggrpytppSGSKSPGSSG...R...S.Q..TP........PGV....ATP.................PI..........PKIT..IQ.....IPKGTITGGKTSSHS...................GYTSS.SSATSSS.....GGTGSTSSKSH..HSHSSSSGKIKSKESSLSQGN.......NSKPGGAVGGSG 1126- 1282 (166.89/33.47) SQSKGSSQ........GVGKPGSSpitkhgfsgpggaG..............SGNKIKPqgGKPPGSLIN..PNVKP.......NIS.........P.........................SHSRSSGSGD...K...L.S..SPmkmqqsqvPG......TP.................PS..........SKAK..SP.....MGSGG......SSSG...................GSKSS.SGGGQSSqkpigGSSSSTASSSS..SSSSSSSGSM.....SFSGGS.......QSQYVGGGGGSG 1285- 1413 (148.88/29.07) GGSGG...........GTGQN.....................................N..SNNPNAKGKspSRNKK...PSLTAVI.........D........K..................LKSVGGGG...V...G.E..DG........CDV....G.P.................PV..........................GGAGSGAPPGGS...................G..NV.SSGPSNV.....GSTKHTSSSQNveYKREKSDKEAKAK.VSVSGGNsgekktmDSKAGG.VGGTT 1421- 1600 (121.91/22.48) KPDGGSPSikakvtlqKAGEGSSD.............SirpqisslkasplfSGSTPKH..DRSSPSHSR..SPAYT...P....LN.........P........D................SESES.GSSSvaeK...ShQ..NS........PSSdddqTMR.................PL..........P.....PQdymssIPLG..SGEKHKKHKkekkkqkekererdrdrerDREKE.KKKSSLS.....MG...LSSHPM..KADSWSRSPISASDSSLSMLS.......SDRP........ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 124.54| 33| 63| 264| 296| 7 --------------------------------------------------------------------------- 264- 296 (61.61/40.39) DLPACFFLKMNRPMPFSTAFIKRMSNTAPSLSP 330- 362 (62.93/41.44) DQQHCYFLNGNAPIQDSHSLQGAMVSKIPFRHP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EKHKKHKKEKKK 2) GSQSQYV 3) GTTLAKIIISK 4) IPKITIQIPK 5) LTAVID 6) MSSIPLG 7) PITKHGF 8) RSSPMYMRNEEDELMDSALTGKF 9) SIKAKVTLQK | 1530 1269 1411 1047 1314 1521 1142 1602 1428 | 1541 1275 1421 1056 1319 1527 1148 1624 1437 |
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