Description | Mediator of RNA polymerase II transcription subunit 9 |
Sequence | MAVAQAKLVKETEDCSLLPLVHDIIKCMDKDSPDVNQELTKLKTKIQETREQISNMSGIDCSPPEQQQQLATLREQVRTKNQLLQKYKGLCMFDVPKAS |
Length | 99 |
Position | Middle |
Organism | Oryzias latipes (Japanese rice fish) (Japanese killifish) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias. |
Aromaticity | 0.02 |
Grand average of hydropathy | -0.584 |
Instability index | 56.33 |
Isoelectric point | 6.56 |
Molecular weight | 11231.91 |
Publications | PubMed=17554307 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364145 |
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP28924 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 97.21| 29| 43| 14| 43| 1 --------------------------------------------------------------------------- 14- 43 (46.91/26.34) DCSlLPLVHDIIKCMDKDSPDVNQELTKLK 60- 88 (50.30/24.85) DCS.PPEQQQQLATLREQVRTKNQLLQKYK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AVAQAKLV 2) DVNQELTKLKTKIQETREQISNMSGIDCSPP 3) LLPLVHDIIKCMDK 4) QQLATLREQVRTKNQLLQKYKGLCMFDVPKA | 2 34 17 68 | 9 64 30 98 |
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