Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MTEMFSTLFGQNEAQGPPGSSSLGFGPGKPPPPMPQNQVPMAGQMTPQLGDDGPTLRKTGAMNEPFYLLRELPVGNELTGNTNLITHYNLEHAYNKFCGKKVKEKLSNFLPELPGMIDSPGTQDGSSLRSLIDKPPVCGNSFSPLTGTMLTGFRLHTGPLPEQYRLMHIQPPKKKSKHKHKHHRPQDPLPQETPSDTDPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPDHPGLAGSQPNSNSLR |
Length | 244 |
Position | Head |
Organism | Oryzias latipes (Japanese rice fish) (Japanese killifish) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.144 |
Instability index | 49.57 |
Isoelectric point | 9.80 |
Molecular weight | 27103.67 |
Publications | PubMed=17554307 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro transcription factor binding GO:0008134 IBA:GO_Central |
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP28917 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 68.01| 13| 17| 200| 212| 1 --------------------------------------------------------------------------- 179- 190 (19.51/ 6.27) .KHKHHRPQDPLP 200- 212 (25.06/ 9.70) KKKKKKRDDDPDR 219- 230 (23.43/ 8.70) KKKKKNR.HSPDH --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 187.08| 45| 69| 28| 80| 2 --------------------------------------------------------------------------- 28- 72 (84.39/27.98) GKPPPPMPQNQV.P.MAGQMTPQLGDDGPTLRKTGAMNEPFYLLREL 99- 130 (37.50/12.56) GKKVKEKLSNFL.PeLPGMIDSPGTQDGSSLRS.............. 133- 170 (65.20/19.58) DK..PPVCGNSFsP.LTGTML.....TGFRL.HTGPLPEQYRLMHIQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPDH 2) KSKHKH 3) YRLMHIQ | 198 175 164 | 230 180 170 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab