<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28915

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSSDEHGSAKNVNFNPAKISSNFSSIIAEKLRFNSFPDTGKRKPQVNQKDNFWLVTARSQSSINSWFTDLGGTKPLTQLAKKVPIFSKKEEVFAYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQCPSQGCSSPPPATPADVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRLLLPLLLQVRAKLREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFNNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCAESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPTLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASESHLPRPRSPSDDESERKEQDAGSSVKMEGSPSPEKNAPDQDSKANCKDKSMDPAFPQLYDQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETGDGEEGQKRKRSKPEAFPTAEDLFSKFQHLSHFDQHQVTSQVSRNVLEQINSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTSLCLCIVAVLRRYHTCLILNPEQTAQVFDGLQIVVKLVVNPADCSSAERCILAYLYDLYTSCSHLKNKFGEIISELCSKVKNSIYCNIDPSDSNMLWDPGFMLEAIANPSAHNFNHSVVGKILNDSPANRYSFVVNVLMDVCMDHRDPERVNDIGILCAELTAYCRSLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSLHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGAKSDKSMVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGMNLSLHRQTRTLRGSGLSHPAGLDDISDRRNVSIETASLDVYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLGNIQAQRLLQLICYPHRQLDSDEGENPQLQRIKRILQVQERGVFQPNGWIGFIKLQLQLLRFVSGASELYSLLENIAKATIEVFQKSAEMNSSNPSGNGTAAHGGSASNSNSTTSKIKPILSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTTRVDRKTTKFEEQHRFLLYHTHMKPKPRSYYLEPLPLPPEEEEPLTPVSQEPEKKIMEPGKPEKNVPPVPAESKKKSSKKKKSAPPKTEVSLLQNHTPHRSLHEDDAVFMSSCIPALCVFQFQRQGMQQTQQQQQTAALVRQLQEQLSSESEALSSTAFHLRRCVF
Length1692
PositionKinase
OrganismOryzias latipes (Japanese rice fish) (Japanese killifish)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias.
Aromaticity0.07
Grand average of hydropathy-0.373
Instability index50.89
Isoelectric point6.51
Molecular weight190009.69
Publications
PubMed=17554307

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28915
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      14|      15|    1483|    1497|       1
---------------------------------------------------------------------------
 1483- 1497 (20.41/16.41)	TKgNKIAGFEK.EGLQ
 1500- 1514 (22.26/12.23)	TK.QKISPWDVfEGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.56|      13|      15|     672|     684|       2
---------------------------------------------------------------------------
  672-  684 (24.90/19.07)	MSYHLPLVQHIQF
  689-  701 (21.66/15.39)	MEYSLNISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.19|      15|      15|    1580|    1594|       3
---------------------------------------------------------------------------
 1580- 1594 (27.20/19.61)	KKIMEPGKPEKNVPP
 1598- 1612 (23.99/16.18)	ESKKKSSKKKKSAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.02|      14|      15|     835|     848|       4
---------------------------------------------------------------------------
  835-  848 (25.92/17.57)	IANPSAHNFNHSVV
  851-  864 (25.10/16.75)	ILNDSPANRYSFVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.80|      52|     371|     368|     419|       6
---------------------------------------------------------------------------
  368-  419 (87.79/61.25)	VVTLLCEWAVCCKRSGRHRAMV......VAKLLEKRQAEIEAERCAESEVVDEKGSVS
  735-  792 (83.01/57.48)	IVAVLRRYHTCLILNPEQTAQVfdglqiVVKLVVNPADCSSAERCILAYLYDLYTSCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.97|      18|      19|     500|     518|       7
---------------------------------------------------------------------------
  500-  518 (26.25/18.80)	SPSdDESERKEQDAGSSVK
  522-  539 (33.72/19.66)	SPS.PEKNAPDQDSKANCK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28915 with Med12 domain of Kingdom Metazoa
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