<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28911
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MELAYVCDWEKRQKNAHCPSIPVVCSWSCRNLVAFTTDLKSDDNEKDVSHMIHIIDTEHPWDVFSINSGHTEVISCLEWDQSGSRLLSADGDGQIKCWSMTDHLVNSWESILSSSLDRDPIIALSWLHNGVKLALHVEMSGSTNFGEKFSRVKFSPSLTLFGGKPMEGWLAVTVSGLVSVSLLKPGGSLLTASESLCRLRGRVALADIAFTGGGNIVVAATDGSSSSPVQFYKVVVSVVSEKCRIDTELLPSLFLRCTTDPMRRDKYPAVTHLKFLTRENSEQVLLCASNQTGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPTILKWRILTTTGDLERVSAVALPKLPIAISNTDLKVAPDTKFCPGLGLALAFHDGSIQIHHRLSLHFMGIYYSSSSSGPRPGDEATLKRQRTSGPFLHFKALQFSWTSLALVGIDNYGKLHMLRVSPSMCQVLDMNTTLRHLLFLLEYCMVTGYDWWDVLLHVLPNMVHNLVEKLHEEYMRQNQALQQVLATRIVAVKASLCKLSAATAARACDFHAKLLLMAISSTLKSLLRPHVLNTPDKSPGDRLSEICAKNTDTDIDKVMINLKTEEFVLDGPPLQSLQQLIQWVGDFVLYLLANLPNQGSMVRPGFGFMRDGASLGMLREMLVMIRIWGLLKPGCLPTFTAMSDSQDSLQLLFRLLTKLWLCSREDGPTQEPDEGLIDECCLLPSQLLVPSMDWLPVNDGVIVKLQGKNPLKLQFGKASSLPGAAGGAPLEALTRSPGSQKMDNLRCVFLGVCPTEESKACTRCGCVTMLRSPNKTNAMKQWEQRWIKNCLCGGLWRRIPAALS |
Length | 833 |
Position | Tail |
Organism | Oryzias latipes (Japanese rice fish) (Japanese killifish) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata>
Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae>
Oryzias.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.011 |
Instability index | 46.88 |
Isoelectric point | 8.03 |
Molecular weight | 92200.00 |
Publications | PubMed=17554307
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | |
GO - Biological Process | positive regulation of transcription, DNA-templated GO:0045893 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP28911
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 104.62| 30| 44| 57| 86| 1
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57- 86 (56.49/31.29) TEH...PWDVFSINSGHTEVISCLEWDQSGSRL
101- 133 (48.13/25.69) TDHlvnSWESILSSSLDRDPIIALSWLHNGVKL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.13| 15| 43| 596| 610| 2
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596- 610 (26.33/15.39) FVLDGPPLQSLQQLI
637- 651 (24.80/14.03) FMRDGASLGMLREML
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 55.97| 16| 43| 292| 310| 3
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293- 310 (28.26/20.34) GSIVECW.........SLrkEGLPVNN
704- 728 (27.71/ 9.83) GLIDECCllpsqllvpSM..DWLPVND
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.56| 29| 134| 517| 570| 6
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330- 359 (43.52/15.81) RILTTTGDLERVSAVALPK........LPIAISNTdLK
517- 553 (39.04/59.26) RIVAVKASLCKLSAATAARacdfhaklLLMAISST.LK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 85.51| 24| 34| 368| 391| 7
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368- 391 (42.97/30.44) PGLGLALAFHDGSIQIHHRLSLHF
405- 428 (42.54/30.06) PGDEATLKRQRTSGPFLHFKALQF
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