<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28901

Description Uncharacterized protein
SequenceMSNNIYQHLQRTSQPSENNKQQQQSLQGLTRDFWQSHLQPQSQMSQHQMLGKKLTAGAIHGKSPMLMANNDVFSIGPYKARKDSVRISVLEKYEIIGYIAAGTYGKVYKAKRKVSSRNESSGTVRTTLNSENSNLGGITTSGSQLGTSTTGSNDKNESIRDIPRTDKIRASEINTIKNNGLSTDGLKKLESFIKKKPIPAYVAIKKFKSEKEGVEQLHYTGISQSACREMSLCRELNNKHLTKLVEVFLERKSIYMVYEFAEHDLLQIIHYHSHPEKKMIPSRMIRSIMWQILDGVSYLHQNWILHRDLKPANIMVTVDGCVKIGDLGLARKFSNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAIDIWAVGCIFAELIGLQPIFKGEEAKMDSKKVVPFQANQLQRILEVLGTPSTKTWTNLNKYPEYDQFGRFVKYRDNLPAWYHSTGGRDKHALDLLYRLLTYDPIRRIDALDALEHSYFTKADFPVCESVFEGLSYKYPARRIHTSDNDIMNLGIHRNKNLDPQQQTINNSTTSTLGGLGVNRRILAAAAAAAAAVSGSGSQSSSRSKEPSRKKRR
Length582
PositionKinase
OrganismKazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.08
Grand average of hydropathy-0.524
Instability index47.78
Isoelectric point9.65
Molecular weight65759.35
Publications
PubMed=22123960

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IEA:EnsemblFungi

GO - Biological Process
negative regulation of filamentous growth	GO:0060258	IEA:EnsemblFungi
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
nuclear-transcribed mRNA catabolic process, non-stop decay	GO:0070481	IEA:EnsemblFungi
phosphorylation of RNA polymerase II C-terminal domain	GO:0070816	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi
protein destabilization	GO:0031648	IEA:EnsemblFungi
response to oxidative stress	GO:0006979	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28901
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.33|      22|     108|     332|     353|       1
---------------------------------------------------------------------------
  332-  353 (41.23/28.53)	KFSNMLQTLY..TG..DKVVVTIWYR
  439-  464 (33.10/21.53)	KYRDNLPAWYhsTGgrDKHALDLLYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.89|      13|      32|     466|     478|       2
---------------------------------------------------------------------------
  466-  478 (24.41/15.34)	LTYD.PIRRIDALD
  500-  513 (20.48/11.79)	LSYKyPARRIHTSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.24|      23|      27|       4|      30|       3
---------------------------------------------------------------------------
    4-   30 (37.01/33.99)	NIYQ.HLQRTSQPSennkQQQQSLQGLT
   32-   55 (41.24/26.99)	DFWQsHLQPQSQMS....QHQMLGKKLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.83|      17|      25|     122|     145|       4
---------------------------------------------------------------------------
  122-  138 (28.74/27.71)	GTVRTTLNSENSNLGGI
  146-  162 (29.09/11.84)	GTSTTGSNDKNESIRDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28901 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKRKVSSRNESSGTVRTTLNSENSNLGGITTSGSQLGTSTTGSNDKNESIRDIPR
2) NNIYQHLQRTSQPSENNKQQQQSLQGLTRDF
110
3
164
33










Molecular Recognition Features






MoRF SequenceStartStop




1) RRILAAAAAAAAAVSGSGSQSSSRSKEPSRKKRR
549
582