<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28897

Description Uncharacterized protein
SequenceMSPSKYLLNPPEELHPYTAIANDKYKNKVPSDQESKLIYPDFGPWKHKKEEDQILLNFVSKGYYVSSKVNFESISARSSLHESLPNLSNELASQFSKVLKIREQEINKISSSDNNPASIDSLRVFNPLAGPGFVLPNRVTLTDNRKELWLQELSSPHTSLHKISKFIPHGLKRRQVIEQCYVKQIPLRRAIWLLKTCYSIEAHALQVKYLNTNSNSKSEWDLNRLINDPNTDLEKISESISSPLYKEWTDNFVYILEKLVFEMNQYYNDAAKLKKWKTELNYFLKLLGNCYSLDLLNKEVFHHWLIEFISKIELFEFLPTALHILTIFWDKLINSSNLPDKSFSLQCNNSTHSTNNNFLVSKITDILLYKYYVVSNAKSMINDESYIINDVRKNTKIKESILSILRNLIWKLFQRSTLDIFLFNASSWDLYKPYIFEIISLKWASSSTVNKGEIKKKLELISYRNETLRSNSLLATSSSAASSPSNTSNWDADYSNIFKSSSKDPNLKVIRIQFADISFTKKLDDNSTAFDWAQYIDQNPLQKTQILQLILWAIHPSRTFHYESMQLVAKILLLQINSSLADNFPEYEIEDLIWSVVFQIAKLNSTNLKLLVCLKSLYKILNILIIYGIIKVPTYIRKLISSGIMYLQDSGDKFLHVNLIINLKISPLMKSQFNMVLRNVIEYDPSFYEQYNFDTLLKAAESNKERLLSGDYDGSSHLNLPQSSKIMLAEACLNHLCSGSSPEPVSSSMIMRMFNLFWLDLDVLYHFYKWIEFIVYHQLLADIDAMETLIDILIKYQKLFSQFVNDHILFTKTFIYIYSKILKGSDALHYNILSFVKFWKFFMKNFPVALIIDNDLKHELSEIYEEEKNKLKKLQEDDEFVHSLFKCLNDIDFHVSNCAKLFQLNIKVIISDSNETEIRQKSRYNLLLLMSANSREYNKLMSIFLKRKSFQEKDLIKLISAKLLTMEQISSTLGISFVLDLLTYNSKNDVRSEIFYQFHEEEFIKSNLKSILISCQLDLSKRYTTFIGLVTTYGPISQYSRIVTTVLMKTLKQRPTMASQIMNDILNFNCRNQDVQASTVDDGEDDDTEDEVSIDEPLLYETYSMLDFTNLWVFQAFTGYQFSKILEKNETQEDIDEYLKEFLYKIFDVTELNELTSELFDEINQIEWIDKIVQLVENDFFENILLDSGENKLSREYLILIVDTTTSLSRKFTKLTSANSSLFFKCFDKCERIISKFVESDNLQPIALQLDVSIKILTIHQNSVLETIVQGLKTESERDRINKFVTNLFKLFEKVSFSLKLKLLLYEILSSLKSYCYYVATLGETSIDDENVSIVPQGRSNSKMQNDFKVPENLINLPPFQVSSFMKVSDDNTDSSVALNLGITPTKDVDYSNDHGRWFIYDKKSKRYVCKFKNVPYNNIKNYQNDTDPVNSFNNGCYNLSLFDASYENKNPH
Length1453
PositionKinase
OrganismKazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.12
Grand average of hydropathy-0.247
Instability index39.64
Isoelectric point6.07
Molecular weight169070.65
Publications
PubMed=22123960

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by galactose	GO:0000411	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28897
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     735.83|     232|     257|     396|     652|       1
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  186-  231 (43.91/16.16)	PLRRAIWLLktcysieahaLQVKYLNTNSNSKSEWD..L..............................................................................................................................................................................................................................................................nrlINDP....NT
  301-  390 (66.35/31.23)	..................................................................................................................................................................................FHHWLIEFISKIELFEF.......LPtALHILTIF..WDKL...INSSNLPDKSFSLQ.CN.....................NSTHSTNNNFLVSKITDILLYKYYVVSNAK.SM...INDEsyiiND
  404-  652 (339.14/291.47)	ILRNLIWKL..........FQRSTLDIFLFNASSWD..LYKPYIFEIIsLKWASSST..VNKGEikkkLELISYRNETLRSNSLLATSS....SAASSPSN.TSNWDADYSNIFKSSSkDPNLKVIR.IQFadISFTKKLDDNStAFDwaQYIDqnPLQKTQIL..QLILWAIHPSRTFHYESMQLVAKILLLQINSSLadnFP.EYEIEDLI..WSVV...FQIAKLNSTNLKLLvCL.....................KSLYKILNILIIYGIIKVPTYIRKLISSGI.MY...LQDS....GD
  658-  915 (286.44/191.09)	...NLIINL......kispLMKSQFNMVLRNVIEYDpsFYEQYNFDTL.LKAAESNKerLLSGD....YDGSSHLNLPQSSKIMLAEAClnhlCSGSSPEPvSSSMIMRMFNLFWLDL.DVLYHFYKwIEF..IVYHQLLADID.AME..TLID..ILIKYQKLfsQFVNDHILFTKTFIY....IYSKI..LKGSDAL......HYNILSFVkfWKFFmknFPVALIIDNDLKHE..LseiyeeeknklkklqeddefvHSLFKCLN.DIDFHV....SNCAKLFQLNIkVI...ISDS....NE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.95|      34|     257|     925|     961|       2
---------------------------------------------------------------------------
  925-  961 (48.47/33.85)	NLLLLMSAN..SREYnkLMSIFLKRKSFQEKdLIKLISA
 1183- 1218 (52.48/26.97)	NILLDSGENklSREY..LILIVDTTTSLSRK.FTKLTSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.52|      53|    1025|     233|     291|       3
---------------------------------------------------------------------------
  233-  291 (80.93/62.45)	LEKISESISSPLYKEWTDNFVYILEKLvFEMNQYyndAAKLKKWKTELNYFLKllGNCY
 1265- 1317 (85.59/48.86)	LETIVQGLKTESERDRINKFVTNLFKL.FEKVSF...SLKLKLLLYEILSSLK..SYCY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.90|      74|    1251|      88|     175|       7
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   88-  175 (102.49/92.43)	SNelaSQFSKVLKIREQEIN....KISS....SDNNpasIDSLRVFNplAGpgfVLPNRVTLTDNRKELWlqeLSSPHTSLHKISKF..IPH.GLKRRQ
 1340- 1424 (113.41/65.69)	SN...SKMQNDFKVPENLINlppfQVSSfmkvSDDN...TDSSVALN..LG...ITPTKDVDYSNDHGRW...FIYDKKSKRYVCKFknVPYnNIKNYQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28897 with Med12 domain of Kingdom Fungi
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