Description | Mediator of RNA polymerase II transcription subunit 9 |
Sequence | MSLSNPDLQAIRDALLPQKVDQSSKTNITGNVATQSTTGEFIPHIFYSLHNIMKNPNQSLNQMENATGFIKHRLKNSKSLIQNNEQLINLLSYDIDYWENYLQNKENEAQIKKNLFAKLSERINNVLEDNGYEREDSPESENDDSAIPRDSTDNDIEISF |
Length | 160 |
Position | Middle |
Organism | Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.866 |
Instability index | 49.15 |
Isoelectric point | 4.68 |
Molecular weight | 18348.96 |
Publications | PubMed=22123960 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364145 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi cytosol GO:0005829 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | structural molecule activity GO:0005198 IEA:EnsemblFungi transcription coactivator activity GO:0003713 IEA:EnsemblFungi |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi RNA polymerase II preinitiation complex assembly GO:0051123 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP28895 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 78.40| 23| 26| 38| 63| 1 --------------------------------------------------------------------------- 38- 61 (39.05/29.82) TGeFIPHIFYSLHNIMKNPNQSLN 67- 89 (39.36/19.20) TG.FIKHRLKNSKSLIQNNEQLIN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 47.24| 15| 26| 91| 108| 2 --------------------------------------------------------------------------- 91- 108 (21.40/19.90) LSYDIDyweNYLQNKENE 119- 133 (25.84/13.53) LSERIN...NVLEDNGYE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DDSAIPRDSTDNDIEISF 2) FIKHRLK 3) FIPHIFY 4) INLLSYDIDYWENYL 5) YEREDSPE | 143 69 41 88 132 | 160 75 47 102 139 |
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