Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MQPQYVRERLDSLECIDLKLCTMLKEASQVVFTFSEIKKGNVDLKRQFENHVKGFYNNLEEATIRLRNEIKLLDENTGTRLLPISVNKKNLGQDEEKLAEQVTLLANVLQDVKNEASTEPLMKDEDEDVLMDG |
Length | 133 |
Position | Head |
Organism | Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.574 |
Instability index | 42.22 |
Isoelectric point | 4.75 |
Molecular weight | 15313.27 |
Publications | PubMed=22123960 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP28886 No repeats found |
MoRF Sequence | Start | Stop |
1) TEPLMKDEDEDVLMD 2) TRLLPISVNKKNL | 118 79 | 132 91 |
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