<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28885

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASGSSMPFSSLHPIPTGSRKPKSLGEFIARVQSDRGFRNVTEESLRKELENKQNDAAEVKEEDTVMAEGIDDSEEPPDAGAARMEVLRNIDVAQNAALMTLDFVSLLLSKESPAQAGVTLSQALREWTGIGTLGIAKREDNEEQKQRDAERAKDNRDVSLGWALLDIETTKASADKAASHLSKEVEREAKYWNEVLAVHQAGWSMCRLPAERHTLGVRFGFSEASPEFRNSSLAPLRRGDDGTALLQHGRVGAGSQRLSITVSRSGETTGRLAIGSSVPDSALLPDRVLEARNTIFAQELWHELHREAHSLASYGVRANNDSINFNPASGPSLTLELESLEDNVAVASTSDDNVLAEATHLGLHILLSHAHRLNELQRLRPTPPHQRRNQAQNQYHLLRPIIAKILYDRSVEQVTSFAGDITRILRRAGVQTAAFTLTTPPCPTADLKNTSGGASNRPNASQALTNMLTSPADFQVELTLTPTSRLQIRGRTFLLPLTTTQFQLQLLPSLAEPPNPEPAPSTLQVSYPPSRDPYPDFSSVQLYIANAASHALADLAMSFIPSPSSEPSDPTLAEWTKSVRGTAIRDIDTETREVRFDILGNGPQGRPTLQIGAAWRAGDKPLIKRWAWPAVGEDAGKSATQPHIGDIVAAVVQSKEI
Length658
PositionHead
OrganismColletotrichum higginsianum (strain IMI 349063) (Crucifer anthracnose fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum destructivum species complex.
Aromaticity0.05
Grand average of hydropathy-0.434
Instability index47.01
Isoelectric point5.74
Molecular weight71705.44
Publications
PubMed=22885923

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28885
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     334.95|     109|     118|     182|     298|       1
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  182-  298 (165.26/126.19)	LSKEVEREAK....YwnevlAVHQAGWSMCRLPAERHTLGVRFGFSEASPEFRNSS....LAPLRRGDDGTaLLQHGRVGAGSQRLSITVS..RSGETTGRLAIGSSVPdSALLPDRVLEaRNTIFA
  301-  419 (169.69/105.95)	LWHELHREAHslasY.....GVRANNDSINFNPASGPSLTLELESLEDNVAVASTSddnvLAEATHLGLHI.LLSHAHRLNELQRLRPTPPhqRRNQAQNQYHLLRPII.AKILYDRSVE.QVTSFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     241.84|      78|      90|     437|     526|       2
---------------------------------------------------------------------------
  441-  526 (114.00/103.06)	PPC..PTADLKNTSGGASNrpNASQALTNM....LTSPADFQVELTLTPTSRlQIRGrTFLLPLTTTQFQLQlLPSLAEPPNPEPapsTLQV
  529-  612 (127.84/77.29)	PPSrdPYPDFSSVQLYIAN..AASHALADLamsfIPSPSSEPSDPTLAEWTK.SVRG.TAIRDIDTETREVR.FDILGNGPQGRP...TLQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.78|      16|      92|      51|      66|       3
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   51-   66 (26.41/16.99)	ENKQNDAAEVKEEDTV
  144-  159 (27.37/17.86)	EQKQRDAERAKDNRDV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.83|      16|      34|      75|      90|       4
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   75-   90 (28.41/19.53)	EEPPDAGAARMEVLRN
  112-  127 (26.42/17.58)	ESPAQAGVTLSQALRE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28885 with Med17 domain of Kingdom Fungi
Unable to open file!