<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28879

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMMXPTARKPSTSKXPVFAKPELKHARSTLLDEGKQKSNADKSAGAKRASSPFDPDTVYKRVRASLADIRSAPQETPTRKGSIFDSVDFDPVLPLVNKKYEQGGRFGCPPIFHGQSQDASKQPGAQWPPTTDYLRRHGRQRRALRQPEHTNALIRTITGNLENSSLVASPGKGDDLASDADDISLVSDQDDSSVSEDEPTSPFKSSIRRINLDDDVASHVTSLREIESMEDSDPTLALDLPKLAKTESSEILIPKYFEDAESLPIHLSLPDEDTITIAQIVTEQAATGILRIRDVHANTLNTAIVADTRRQLSYLGRTALQALREVIPPCLGEFNICNFKSVVEVPDVPLIGPPNRLHPRPVNPRDAAEPPKPNNLFQIPAPHMELRRAEARLSVLPASVQFWESLGLGPAQGTKDVNVVCVFPHWDGMSDIAASFLDRMRNVYELLKLGSFERLPPSSKVTDGLMPFEADKIATSPGTVSPHIVAGLGDRMEALNQALISANATEKNFLIYFVYPPDHPGSIVEACTAFQQLFEMHRRSLTDRRQSPTNELVLQLVPLDFLTSSTGIVEPTPSDVIRLAIETYDRCTLFGGPMPSPAIMLEQSLPRGIDFKLSNTSSSSLMHENTCIHIAYAQSIDERWITAAWTDNRGCQQMTASYNLGRKGKPLSTSLNDVYHEIWETTHDLISKWKVHWRVIISKCGYMDAQEIGFWQGLAQTESIATVSLTLISVDTNPSMQLVPPPIKVQATASSAFYTTPVSTPQASIVSPEQSGTPVTPMKENNPATAATPGGTPVDGNADPAEGDAILLDVTDQTWGAVLAHRLSNSSSLGEMNSALVSGYLVKRGGTKLEDPPVVMEVNIVHADNNPRMYEPLMREMLTYFRGLGTLARARGIVDRGTDVRPWHIAAAEKGVRALYLLM
Length918
PositionKinase
OrganismColletotrichum higginsianum (strain IMI 349063) (Crucifer anthracnose fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum destructivum species complex.
Aromaticity0.06
Grand average of hydropathy-0.326
Instability index47.82
Isoelectric point5.64
Molecular weight100424.62
Publications
PubMed=22885923

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28879
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.68|      32|      39|      23|      54|       1
---------------------------------------------------------------------------
   23-   54 (53.43/32.51)	KHARSTLLDEGKQKSNADKSAGAKRASSPFDP
   59-   90 (54.25/33.11)	KRVRASLADIRSAPQETPTRKGSIFDSVDFDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.42|      19|      39|     173|     191|       2
---------------------------------------------------------------------------
  173-  191 (31.04/22.66)	DDLASDADDISLVSDQDDS
  213-  231 (31.38/23.00)	DDVASHVTSLREIESMEDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.32|      36|      40|     371|     408|       3
---------------------------------------------------------------------------
  371-  408 (54.05/39.29)	KPNNLFQIpAPHMElRRAEARLSVLPASVQFWESLGLG
  414-  449 (64.27/37.41)	KDVNVVCV.FPHWD.GMSDIAASFLDRMRNVYELLKLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.38|      14|     485|      91|     115|       4
---------------------------------------------------------------------------
  102-  115 (30.48/36.77)	GGRFGCPPIFHGQS
  590-  603 (27.90/ 8.80)	GGPMPSPAIMLEQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.55|      19|      22|     236|     254|       5
---------------------------------------------------------------------------
  236-  254 (30.14/20.43)	ALDLP.KLAKTESSEILIPK
  259-  278 (27.42/17.83)	AESLPiHLSLPDEDTITIAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.12|      29|      33|     728|     760|       7
---------------------------------------------------------------------------
  728-  760 (42.29/33.67)	SVdTNPSMQLVP.PPIKVQATASSAfytTPVSTP
  763-  792 (47.83/25.71)	SI.VSPEQSGTPvTPMKENNPATAA...TPGGTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.13|      33|      39|     606|     641|       8
---------------------------------------------------------------------------
  606-  641 (52.76/43.62)	RGIDfklSNTSSSSLMHENTCIHIAYAQSIDERWIT
  648-  680 (59.37/40.37)	RGCQ...QMTASYNLGRKGKPLSTSLNDVYHEIWET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.09|      33|     396|     121|     153|      10
---------------------------------------------------------------------------
  121-  153 (61.92/45.26)	QPGAQWPPTTDYLRRHGRQRRAL..RQPEHTNALI
  518-  552 (54.18/38.54)	HPGSIVEACTAFQQLFEMHRRSLtdRRQSPTNELV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28879 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASDADDISLVSDQDDSSVSEDEPTSPFKSSIR
2) GRFGCPPIFHGQSQDASKQPGAQWPPTTDYLRRHGRQRRALRQPEHTNALIRTI
3) MMXPTARKPSTSKXPVFAKPELKHARSTLLDEGKQKSNADKSAGAKRASSPFDPDTVYKRVRASLADIRSAPQETPTRKGSIF
4) TPQASIVSPEQSGTPVTPMKENNPATAATPGGTPVDGNADPAEG
176
103
1
759
207
156
83
802










Molecular Recognition Features






MoRF SequenceStartStop




1) FWRQFTP
23
29