<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28872

Description Transcription mediator subunit Med12
SequenceMVVQPRPPQQQRTLSSSGLSVQRPTHQRTLSAQYLPQSPVRKENLIDLTGDANDAAVAQNRYGTLPRRGGSRLKLELSNEAMLAQHPVTDSPQILTPSRLLPKNESSNLTDMSSPASAKGHGVDADNPPMPMPKRRPRFVVPAAVKDTPTPALAIKKDGRPKPWHFETPPAAPRYAPFGKPRTDAATKSAFGAPARETSELGHADFFPWNGNHPEDQYSETVIKTGYYDKPPASSATETSSAKAALFPALKHKSGLNLLSNIFVGVLNQRKLNGQISSPSTFKPPPRVTLTDTKREMWLRDLANPSISLRRLSRTIPHGIRGKVLLDHCLNKNVPTERAVWLVKCVGANEIRAFKRKGNGPGPFVLGGEAKWLRDWTVFVEQFLEGVSTAFGDNDWKAKVQYAIRLATHLYAEQLLDRDHYMDWLVSGLENSTQSKLPMWILITQIYWKDLLRLRRYGRRLVNALLSHLYAIHNDPDRDILVQLSTRLTSLLSPLLSAHPDNFVSPATWFKYRDALLASIPIDHEFAQSAFRSINTRNEQLVASASNSQPANRQILVKHLDTSFTSLYNPDLVAQCWAVSEDKGMIVRTLLEWCTSPHRPGASKVYITASLLRAWAAAGVDVTTAVLEFLSNNPPTERNSKRVFHRLMSEIVRTGDFQLQGYIFWLIARGGLRKPADTEADGSCATRLLVDLPLHALNPSSQATRASLLRRASYDVNDEVEDITTALKCIHHALGLPLPPGDPMLQRKPVPVGKLCRLISTSSRALQTEVGARLLQIFTAEIITTKNGPQVSPAMFNFARAVLEAASDFSVLAEIIKTAARASNPEILASCADTLNVHLPIFAALGVAKEVFDFLMERLKTVSEEQGPAARPLLASLANLAARLPGFTNTASYLRQQLHQCDRNNPIDACSPVSDNMTAQLQDAEGELHEEIEKLLASGTSVDRPTMDRLFQTVVGRLESCWSKSPDRQRAYSALLGRLRIFDTQHFDVRMTDWVHHISTLKARPALVDIYPLLISMGCLTLPIILTTTSVDAGRMAPGSSGPFNSTTTHTQEVLYLATMPLAAKTALTPEESYRFYIQQQVVPRQSHKDMVVLIRNALVEYSRLQGVADPALLPLANPGFRDSVLELLKLLVLRDAPSVVQGLSTKTSEPALTTLFAQITTKLLLPDASDESPLTFETVLELANEFTLPFCQLKLSVGLSADSTTSPGGGEQALTQFDMFSRAMDRAVSANNVMWTSMLPYLSEEITEHLKKQAHLRFLGLFPSQKNPPASDPLSQESVQLAGSLLSVVEAILRGRPAVRTSQLTSGMVEKLAELWEILAAGGDDKKDLRASILRYWLPALLKFITLHTTANDPLCAPAQAQAANNMKPPANATAYEIRARILIVLSGLTLELDSLALQDPQTGRLLSQQVFDLALMLIDTLPEDARLQCVRVLLTGGTMQNPASSDARLRYLFSYMPAQTEQFVLAHRQQPTTTQQNGPPRPKIPISMQGTDRLTPFVYRKWEMLSEPTPNVGENDTALSLTLFEAIKIQ
Length1532
PositionKinase
OrganismColletotrichum higginsianum (strain IMI 349063) (Crucifer anthracnose fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum destructivum species complex.
Aromaticity0.07
Grand average of hydropathy-0.209
Instability index44.23
Isoelectric point8.92
Molecular weight169191.99
Publications
PubMed=22885923

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28872
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.26|      68|     238|     863|     936|       1
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  863-  936 (110.05/74.21)	SEEQGpAARPLLASLANlaarlPGFTNTASYLRQQLHQCDRNNPIDACS.....PVSDNMTAQ......LQDAEGELHEEIEKLL
 1103- 1181 (102.21/56.17)	SRLQG.VADPALLPLAN.....PGFRDSVLELLKLLVLRDAPSVVQGLStktsePALTTLFAQittkllLPDASDESPLTFETVL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.22|      29|     386|     543|     612|       2
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  471-  499 (51.21/11.11)	AIHNDP.DRDILVQ.LSTRLTSLLSPLLSAH
  545-  575 (43.01/81.57)	ASNSQPaNRQILVKhLDTSFTSLYNPDLVAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.60|      94|    1136|     230|     336|       3
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  230-  336 (134.44/101.73)	KPPAsSATeTSSAKAALFPALkhkSGLNL.LSNIFVgvlnQRKLNGQISSPSTFKPPPRV..TLTDTKREMWLR......DLANPSIS...LRRLSRTIPHGIRgKVLLDHclnKNVPT
 1369- 1474 (142.16/74.91)	KPPA.NAT.AYEIRARILIVL...SGLTLeLDSLAL....QDPQTGRLLSQQVFDLALMLidTLPEDARLQCVRvlltggTMQNPASSdarLRYLFSYMPAQTE.QFVLAH...RQQPT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.31|      16|     385|     576|     591|       4
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  576-  591 (29.62/22.78)	CWAVSEDKGMIVRTLL
  961-  976 (30.68/23.91)	CWSKSPDRQRAYSALL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.05|      52|    1136|      76|     127|       9
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   76-  127 (88.07/52.39)	ELSNEAMLAQHPVTDSPQILTPSRLLPKNESSNLTDMSSPASAKGHGVDADN
 1182- 1233 (87.98/52.32)	ELANEFTLPFCQLKLSVGLSADSTTSPGGGEQALTQFDMFSRAMDRAVSANN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.35|      15|     285|     504|     519|      10
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  504-  519 (25.19/17.89)	VSPAtWFKYRDALL..AS
  791-  807 (23.17/11.42)	VSPA.MFNFARAVLeaAS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     230.54|      78|     621|     625|     710|      11
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  625-  710 (116.06/97.51)	AVLEFLSNnPPTERNSKrVFHRLMSEIVrtgdfQLQGYIFwLIARGGLR.KPA.DTEADGSCATRLLVDL..PLHALNPSSQATRASLLR
 1255- 1336 (114.48/70.92)	AHLRFLGL.FPSQKNPP.ASDPLSQESV.....QLAGSLL.SVVEAILRgRPAvRTSQLTSGMVEKLAELweILAAGGDDKKDLRASILR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28872 with Med12 domain of Kingdom Fungi
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