<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28871

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMLENGMNGSMQVDQLDVDDLFGDGVGLSLHTARPPTKHLRQRIDDLRTRGCCQGIAWSRSGAIASISPDGKTLEARFLRSHPDDGNWGLSEPTKVDLITINATSPIVHLAWASTTSPELAVIDATGRVAILTYSITLNRPFATRKWDHDPSDDLHAIVGSYWLPLAPQSKQYYVSHGPAVRDGNQYRYESSFVHAYGPWHPNPSKSALLCVTTNGHLKMFWAQNNNKIEETTLELESVNSSDDLVTHAALHSDKSSLWVALATTSKQLRVVRVGIHWGLPQSQSDNKPPPGSQALNPTMQEKHVAISSWLPSGSSATPIDSAANQLTHLEILPSTLDHTGQGWAPLIILAVRTYLSTPNTPYQETQSIIDKWEVLNDQSQSLHPAFEQLGSRRNSTGAAPAPTSRLKKFDPVVINKAIVGVHTIQYGRVICLAFSDGSVEYRDRFTLQEIYNEMNLDRVMTLNQVGFTLQDESPCLQMAFSPTNCSIIKIQDDGKVKWSKMHYPLGDIGNSSQDAPYAATLAALTVAASTATFNNINYDDILAVARPYADKNRFTSDWINEIVRMLKIPVDYSEDTHHDSLVRNSSLQMCLSILNHLGYKGMFQPRSFGGKFAMLALNARNVVILITIASNTPATIREKLSPLDEHEVVDALAGCAKWSLDLLSWLTDCLFALLDDQQFLALLTPQRFSEISTYLQSRSDVSLHLLLCSSTRGFLSAVCRRILHLEILSNRAIEFYERRAAMQKATDPSSQNKALHVVLYKAYQKMQRVTSSSLIKVQEFDRLLTVLNNDIRSAYQSSFASLASKNPPGAGGQKALDAQIKNAQTRCELSMLLAASPPPAFLPVLLKFFNTDLKTYRAQADPSKLFFADFTLLEIDDDRRTLAARKAKGRFIDVFKRVELATPSADSTKEGEDAKLAQWRRCVRCSAVMEDVFGSRPGFTFVLAQQRKCSCGGHWGLLPKDVLII
Length968
PositionTail
OrganismColletotrichum higginsianum (strain IMI 349063) (Crucifer anthracnose fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum destructivum species complex.
Aromaticity0.08
Grand average of hydropathy-0.222
Instability index43.82
Isoelectric point7.35
Molecular weight107370.94
Publications
PubMed=22885923

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28871
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     274.72|      94|     146|      99|     204|       2
---------------------------------------------------------------------------
   77-  191 (138.16/105.00)	EARFLRSHpddGNWGlSeptkvDLITInATSPIVHLAWASTTSPELAVIdatgRVAI...LTYSITLNRPFATRKWDHDP..................SDDL..HAIV....GSYWLPLAPqskqyyvSHGPAVRDGNQYRY
  192-  264 (45.78/19.68)	ESSFVHAY...GPWH.PnpsksALLCV.TTNGHLKMFWA.........................................qnnnkieettlelesvnsSDDLvtHAALhsdkSSLWVAL.......................
  265-  331 (90.78/49.66)	.......................................ATTSKQLRVV....RVGIhwgLPQSQSDNKPPPGSQALNPT..................MQEK..HVAI....SS.WLPSGS.......SATPIDSAANQLTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.15|       9|      24|     919|     928|       5
---------------------------------------------------------------------------
  919-  928 (16.93/17.44)	LAQWRRCvRC
  946-  954 (19.21/13.37)	LAQQRKC.SC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.88|      21|      23|     855|     877|       7
---------------------------------------------------------------------------
  855-  877 (31.97/26.11)	DLKTYRAQadPSKLFFAD.FTLLE
  881-  902 (28.91/16.67)	DRRTLAAR..KAKGRFIDvFKRVE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28871 with Med16 domain of Kingdom Fungi
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