<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28868

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIVTMENGGLNGTHLSHSRDLKTNGVNGGKMEGQPSPNKGKAPADDAPATDDMANGASDAKGKQQPQMSTGLTLQQKPRMNDLPEEIVHITQGYIPLSMIVSRLAQRTHEDLEKTIMDMAAIKWAPPAVNGNTPNGTDIPDDMSEGNKRKKMLMLKFAQDAHSKWVKALVITDWSRNAEAVSKLIDIKAHIDSKRMLFDFCQDLLIDLKRSLISARLPNPDLKTALQVLTTGEASWIPEPGYIPPPPLTPEEQLKWIDDLNTMLSLRLNLDDYDKIPHQFKDYTIHSGRVTFKVKGEFEVDLTIADEDFTRQFWFIDFRFSFSPSSSKLSDTLVSYLELRVNEILGQDGLEGCYQFLHEFVLTHKINELRRQAIELSRSTWTGTLMVEPLNRALALQYWTARYGPNGPKSWVMVAVNSAKRTNGQTDPKHSSRLVARWYRDNKEVKDVFLPFDVDNLCAEDLLKTAVARHVEHILSSIHAKLLSYPRFVKRESSMTLKISRTEPMESCLGMQLGSRDNVTLIVQPVTGFAAIKPHTKYSLNGENRLNYGGKDPAEDGVICLENIRWGYVIEEFNRRGRSVGWKTCKSPIGSEEIKQIIRTREGFQTIFLQRQSLGQEWYVMVSLSLSGDEWWLLEINRNTPGRPIKFQTKLELTRGQPDLDDSFWSNLTLFVTGIIAQATDLEDLHQKEVKHLTKESTNYSLPQQVRLPSLILKLSQILRPSETSSAHDTSKDALYRSSNNSLSWAQDQIEVKFRGLLPQPSVTLDQHDNSLSAVEVLENIRLNTVVDAAVRVKDKAKFALLKGRIDRDVSFSPKKGEFIFRIRQSIGQPILETLTTHVNSIDRLVGFLEAMGKARGDVRCEKVSLKQVIFTYSDMIMPGESGSTQKPQRWRVSLDLAKSDIRMSLERGNPHLRVLDLLTTLVNTQNGLKALLVYMPLLLPILRTLDNIESKWEPLATTNQGRLEIFPRSVDWIALRYTLPSTNGQPRILVLEIRSKLRRSEVWWNFSRTIPGGPAPPDEGFNRVLKRIWESHGDGWRGLTTGAAAQPGPSTMELLTRLDDAVRAYAVTGDISEAPLTQEAQTQSSQTFSANQSFGTQPTSVSQGSNRSSGGSKQAPLVLD
Length1123
PositionTail
OrganismColletotrichum higginsianum (strain IMI 349063) (Crucifer anthracnose fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum destructivum species complex.
Aromaticity0.07
Grand average of hydropathy-0.424
Instability index42.35
Isoelectric point8.47
Molecular weight126292.50
Publications
PubMed=22885923

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28868
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.03|      23|      30|     966|     989|       1
---------------------------------------------------------------------------
  942-  963 (35.33/15.62)	LPI...L.RTLDNIESKWEPLATTNQ
  966-  988 (40.74/19.70)	LEI...FPRSVDWIALRYTLPSTNGQ
  994- 1019 (35.96/17.43)	LEIrskLRRSEVWWNFSRTIPGGPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.66|      27|      28|      27|      54|       2
---------------------------------------------------------------------------
   27-   54 (44.30/28.01)	GVNGGKMEGQPSPNKGkAPADDAPATDD
   58-   84 (47.36/25.96)	GASDAKGKQQPQMSTG.LTLQQKPRMND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.48|      48|     143|     627|     677|       3
---------------------------------------------------------------------------
  627-  677 (76.24/69.81)	SLSGDEwwLLE.INRNT....PGRpIKFQTKLELTRGQPDLDDSFWSNLTLFVTGI
  773-  825 (68.23/47.42)	SLSAVE..VLEnIRLNTvvdaAVR.VKDKAKFALLKGRIDRDVSFSPKKGEFIFRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     321.36|     107|     151|     288|     410|       4
---------------------------------------------------------------------------
  288-  410 (160.43/135.88)	HSGRVTFK.......VKG...EFEVDlTIADEDFTRQFWFIDFRFSFSPSSSKlsdtLVSYLELRVNE......ILGQDGLEGCyqflhefvLTHKINelRRQAIELSRSTWTGTLMVEPLNR.ALALQYwTARYGPNGP
  432-  555 (160.93/98.19)	HSSRLVARwyrdnkeVKDvflPFDVD.NLCAEDLLKTAVARHVEHILSSIHAK....LLSYPRFVKREssmtlkISRTEPMESC........LGMQLG..SRDNVTLIVQPVTGFAAIKPHTKySLNGEN.RLNYGGKDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.88|      18|      28|     865|     885|       5
---------------------------------------------------------------------------
  865-  885 (28.26/28.21)	KVSLKqviFTYSDMIMPGESG
  894-  911 (30.62/20.87)	RVSLD...LAKSDIRMSLERG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.20|       8|     147|      85|      98|       6
---------------------------------------------------------------------------
   85-   98 (11.54/18.17)	LPEeivhitQGYIP
  239-  246 (18.66/ 9.53)	IPE......PGYIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.62|      19|     488|     218|     237|       7
---------------------------------------------------------------------------
  218-  237 (29.08/19.96)	RLPNPDLKTAlQVLTTGEAS
  709-  727 (32.54/18.07)	RLPSLILKLS.QILRPSETS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.67|      23|      28|    1028|    1054|       9
---------------------------------------------------------------------------
 1028- 1054 (35.58/26.20)	LKRIweshGDGWRGLTTGAAAQPGPST
 1058- 1080 (37.10/17.53)	LTRL....DDAVRAYAVTGDISEAPLT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28868 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGIVTMENGGLNGTHLSHSRDLKTNGVNGGKMEGQPSPNKGKAPADDAPATDDMANGASDAKGKQQPQMSTGLTLQQKPRMNDLPEEI
2) SEAPLTQEAQTQSSQTFSANQSFGTQPTSVSQGSNRSSGGSKQAPLVLD
1
1075
89
1123










Molecular Recognition Features






MoRF SequenceStartStop




NANANA