<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28860
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MAGVPVVRISIESACEKQVQEVGLDGSETYLQPLSMSQNLARLAQRIDFSQGSGSEEDEPGSAGRPWAEPGEAEDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVKDKKFMTLDPVGQDPLPPKQNPQFLQLISKKKSLAGAAQILLKGAERLSKSVAENQENKRQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFLHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSAHWQTKLETAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPGLQLSISLCHSSNDKKSQKAASEKQNPEDHLYVLEHNLHQLIRECHKQTLSSTVMPHPASAPFGHKRMRLAGPQAFDKNEISSLQSNEGLLEKIIKQAKHIFLRRRTARTIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWHVLSFSNHVGLGPVESIGNASAITVASPNGDYAISVRNGPESGSKVMVQFPRSQCKDLPKGDVLQDSKWNHLRGPFKEVQWNKMEGRNFVYKMELLMAALTPC |
Length | 643 |
Position | Head |
Organism | Taeniopygia guttata (Zebra finch) (Poephila guttata) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda>
Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae>
Estrildinae> Taeniopygia.
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Aromaticity | 0.06 |
Grand average of hydropathy | -0.453 |
Instability index | 54.08 |
Isoelectric point | 8.39 |
Molecular weight | 72070.46 |
Publications | PubMed=20360741
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Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
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GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
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GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
stem cell population maintenance GO:0019827 IEA:Ensembl
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Interaction
Repeat regions
Repeats |
>MDP28860
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 451.64| 121| 219| 12| 136| 1
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15- 136 (202.91/152.47) CEKQVQ.EVGLDGSeTYLQPLSMSQNLARLAQ..RIDFSQGSGSEEDEPGSAGRPWAEPGEAEDEEGLVKFQPSLW....PW......DSVRNNL..RSALTEMCVLYDVLS..IVKDKKFMTL.....D.PVGQDPLPPKQNPQ
137- 233 (88.65/57.12) ................FLQLISKKKSLAGAAQ..IL....LKGAERLSKSVAEN..QENKRQRD......FNSELLrlrqHWklrkvgDKILGDLsyRSAGS.LFLHHGTFE..VIKNTD.IDL.....DkKIPED.........
235- 359 (160.08/108.19) CPLDVQiPSDLEGS.AYIK.VSIQKQAPDIGDlgTVNLFK.RPLPKSKPGSA..HWQTKLETAQNVLLCKEIFAQL....SR......EAVQ..I..KSQIPHIVVKNQIISqpFPGLQLSISLchssnD.KKSQKAASEKQNPE
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