<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28855

Description Cyclin dependent kinase 19
SequenceRKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTSDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQNQHQQQTAPQQQAQAAPQQPQPQQQNSSQTNGTAAGAGGAGGGAGAGLQHSQDSSLSQVPPNKKPRIGPSGTNSGGPVMPSDYQHSSSRLSYQSNIQGSSQSQSTMGYSTSSQQSSQYHQSHQSHRY
Length460
PositionKinase
OrganismTaeniopygia guttata (Zebra finch) (Poephila guttata)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae> Estrildinae> Taeniopygia.
Aromaticity0.08
Grand average of hydropathy-0.727
Instability index61.56
Isoelectric point8.77
Molecular weight52110.18
Publications
PubMed=20360741

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28855
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     167.56|      41|      41|     274|     314|       1
---------------------------------------------------------------------------
  235-  271 (31.68/14.08)	.....PTlqkdfRRTTYANSSLIKYMEKHKVkPDSKVFLLL......Q
  274-  314 (72.90/42.09)	LTMD.PT.....KRITSEQALQDPYFQEDPL.PTSDVFAGCQIPYPKR
  317-  357 (62.99/35.35)	LNEDePE.....EKGDKNQQQQNQH.QQQTA.PQQQAQAAPQQPQPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.61|      21|      37|     365|     390|       2
---------------------------------------------------------------------------
  365-  390 (28.41/21.91)	GTAAGaggaGGGAGAGLQHSqDSSLS
  404-  424 (41.20/18.20)	GTNSG....GPVMPSDYQHS.SSRLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      37|     109|     123|       3
---------------------------------------------------------------------------
  109-  123 (26.77/19.20)	DLKPANILVMGEGPE
  147-  161 (28.67/21.07)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28855 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLNEDEPEEKGDKNQQQQNQHQQQTAPQQQAQAAPQQPQPQQQNSSQTNGTAAGAGGAGGGAGAGLQHSQDSSLSQVPPNKKPRIGPSGTNSGGPVMPSDYQHSSSRLSYQSNIQGSSQSQSTMGYSTSSQQSSQYHQSHQSHRY
309
460










Molecular Recognition Features






MoRF SequenceStartStop




1) QSTMGYSTSSQQSSQYHQSHQSHRY
2) QVPPNKKPRIGPS
3) SRLSYQSNIQGS
436
391
421
460
403
432