<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28842

Description Mediator complex subunit 12
SequenceMAAFGVLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINNWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFIEWTQIITKYLSEQLQKIAEFYRQLPGQGCGSPSGPMPQEVEQALKQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRSGEDEFLKMLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLAMQLDGAGGHPPHILSAQTGNALPSTPTPQPAAGNPPPSPFSDLLLCPQHRPVVYGLSCILQSIILCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPGGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGLGPTKDSHEISPDDDAVVALLCEWAVSYKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSISSGSLSAASAPVFQDVLMQFLDTQAPMLTDPGKENEKVEFFNLVLLFCELIRHDVFSHNIYMCTLISRGDLAMDSHGPRPPSPFDDAAEEHDRKETEGSSGIKLEDTGLSEPMDIDHNPSMLFDDMEKTDFSMFSPPMHCESKASPSPEKPDPEKEAKTLLKDKSVEGMLASLYDQPRHIQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHTIKKITKDILKVLNRKSTAETGNFDSWVKINRKHLINFCGEEGQKRKKSKPEAFPTAEDIFAKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHSCLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEPEFMIDTIENPSAHNFTYTNLGKSLNENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVETVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHPGGVDDLMDDELGTRKAGGRVVTVETASLDIYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSTQAQRLMQLICYPHRLLDNEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTASNEMNSLLENIAKATIEVFQQSAETSSASFNNISSSTSATPASNKSKPILSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTVRVDRKVSRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVALEPEKKTAEPAKADKTSSNPAASTEERKKKQSKTKKRNQSASKTEDFVLGPSRGVSYGVGMPTDLLHHQSGSTMSRLAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPYSGVLPPGMGSMMGIDPSYKPAVYRQQPPVSQGQILRQQLQAKLGIMGQQPVRQMAPTPSYGALQPSQGYTPYVSHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLANTQRFPHQSIQQTPMMSGMNHLGPQGVPSGIRPSQILPDQQQQQYLRQQQQQQMLRVSVTQHELKPDVRKMVHEVFYSMEHHSPLSPRCAPQQQQQQQQQQQQQQQQQQQPQPPQPQPQQQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQTQQNNNPFGRY
Length2178
PositionKinase
OrganismTaeniopygia guttata (Zebra finch) (Poephila guttata)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Passeroidea> Estrildidae> Estrildinae> Taeniopygia.
Aromaticity0.07
Grand average of hydropathy-0.479
Instability index53.84
Isoelectric point6.92
Molecular weight243993.71
Publications
PubMed=20360741

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28842
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.23|      24|      25|    2101|    2124|       1
---------------------------------------------------------------------------
 2052- 2077 (27.24/ 7.93)	....PDQQQQQYLRQQQQQQmlrvsvTQHE
 2101- 2124 (50.66/21.18)	PRCAPQQQQQQQQQQQQQQQ......QQQQ
 2128- 2151 (45.33/18.17)	PQPQPQQQPQFQRQGLQQTQ......QQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.48|      32|     112|     192|     223|       2
---------------------------------------------------------------------------
  192-  223 (61.23/26.61)	TKYLSEQLQKIAEFYRQ.LPGQ.GCGSPSGPMPQ
  301-  334 (51.24/21.19)	TRRLAMQLDGAGGHPPHiLSAQtGNALPSTPTPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.94|      14|      18|    1661|    1678|       3
---------------------------------------------------------------------------
 1661- 1678 (13.23/24.00)	TKgNKIAGFDsIFkkEGL
 1682- 1695 (28.71/19.08)	TK.QKISPWD.LF..EGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.14|      11|     112|    1002|    1012|       4
---------------------------------------------------------------------------
 1002- 1012 (23.09/14.82)	NTIYCNVEP.SD
 1111- 1122 (17.06/ 8.95)	NDLLCNVETvSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     206.58|      27|     112|    1837|    1863|       5
---------------------------------------------------------------------------
 1837- 1863 (51.92/29.33)	GQSPVGLYAQNQP.....LPAG....GPR.L..DTS..Y..RP
 1869- 1898 (25.92/10.01)	GK.....LVQSRPpysgvLPPG...mGSM.MgiDPS..Y..KP
 1925- 1949 (38.99/19.73)	GQQPVR...QMAP.....TPSY....GA..L..QPSqgY..TP
 1954- 1975 (26.32/10.32)	....IGL..QQHP......SQS....GTM.V..PPT..YsgQP
 1995- 2013 (27.42/11.13)	QQRPSG.YVHQQA......PGY....GHT.L............
 2016- 2047 (36.01/17.51)	TQRFPHQSIQQTP.....MMSGmnhlGPQgV..PSG..I..RP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.21|      24|     112|    1587|    1612|       7
---------------------------------------------------------------------------
 1563- 1586 (39.25/25.67)	LDIISSGTV..DMQSNNELFTTVLDM
 1587- 1612 (33.95/27.80)	LSVLINGTLaaDMSSISQGSMEENKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.83|      14|      16|    1764|    1779|       8
---------------------------------------------------------------------------
 1741- 1754 (23.15/ 7.10)	EPLPLPPEEEEPPT
 1766- 1779 (22.68/13.31)	EPAKADKTSSNPAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.85|      15|      15|    1390|    1404|      16
---------------------------------------------------------------------------
 1369- 1382 (20.78/12.73)	SNEMNSL.LENIAKA
 1390- 1404 (23.83/15.89)	SAETSSASFNNISSS
 1406- 1420 (23.24/15.28)	SATPASNKSKPILSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.66|      34|     162|    1463|    1501|      17
---------------------------------------------------------------------------
 1463- 1501 (52.91/36.89)	RKE.RDRQK...QKSMSLLSQQPFLSLVLTClkgqdEQREGLL
 1622- 1659 (50.76/25.61)	RKElGDRQSdslEKVRQLLPLPKQTRDVITC.....EPQGSLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28842 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GVGMPTDLLHHQSGSTMSRLAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPYSGVLPPGMGSM
2) IDPSYKPAVYRQQPPVSQGQILRQQLQAKL
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN
4) LAMDSHGPRPPSPFDDAAEEHDRKETEGSSGIKLEDTGLSE
5) PYVSHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLANTQRFPHQSIQQTPMMSGMNHLGPQGVPSGIRPSQILPDQQQQQYLRQQQQQQMLRVSVTQHELKPDVRKMVHEVFYSMEHHSPLSPRCAPQQQQQQQQQQQQQQQQQQQPQPPQPQPQQQPQFQRQGLQQTQ
6) SYYLEPLPLPPEEEEPPTPVALEPEKKTAEPAKADKTSSNPAASTEERKKKQSKTKKRNQSASKTEDFVLGPSRG
1815
1892
15
623
1949
1737
1889
1921
61
663
2147
1811










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGV
1
6