<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28828

Description Mediator of RNA polymerase II transcription subunit 13-like (Fragment)
SequenceXINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFSAGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTKKPQEPPISLLLLLQNQHTQPFASLNFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISADRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQVTVCKFIIYF
Length1545
PositionMiddle
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.07
Grand average of hydropathy-0.482
Instability index58.96
Isoelectric point5.48
Molecular weight168120.25
Publications
PubMed=16541075
PubMed=18691976
PubMed=19369195
PubMed=19690332
PubMed=23186163

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28828
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     443.83|     103|     113|     168|     272|       1
---------------------------------------------------------------------------
  131-  196 (59.26/24.52)	......................................................................CGM.PLTPP...T...SPeqailGESGG.............MQSAASHLVSqdggmiTMHSPKRSGKIP..PKLHNHmvHR..VWKE.CIL
  197-  310 (166.57/71.70)	NRTQSKRSQMS..TP............TLE.EEPASNPATWD..FVDP.TQRVSCSCSRHKLLK.....RCAVGPNRPP...TVS.QP.....GFSAG.............PSSSSSLPPPasskhkTAERQEKGDKLQkrPLIPFH..HRpsVAEElCME
  311-  384 (71.38/25.83)	QDTPGQKLGLAgiDS............SLE....VSSSRKYDkqMAVP.....SRNTSKQMNLNpmdspHSPISP.LPP...TLSpQP........RG..............QETESLDPP........................................
  809-  901 (69.34/24.85)	NNVPSVGS.LA..DPdylntpqmntpvTLNsAAPASNSGAGV..LPSPaTPRFSVPTPR..............TPRTPR...TPR.GG.....GTASGqgsvkydstdqgsPASTPSTTRP........................................
 1349- 1415 (77.27/28.64)	QATPGNAGPLA..................P.NGSAAPPAGSA..F.NP.T...SNSSSTNPAAS.....SSASGSSVPPvssSAS.AP.....GISQI.............STTSSS............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.18|      23|      49|     615|     637|       2
---------------------------------------------------------------------------
  615-  637 (41.10/23.92)	PSLHDLDNIFDNSDD.DELGAVSP
  666-  689 (40.08/23.11)	PTVADLQRMFPTPPSlEQHPAFSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.75|      14|      16|    1046|    1060|       3
---------------------------------------------------------------------------
 1046- 1060 (21.68/15.78)	PFASLNFlDYI.SSNN
 1065- 1079 (24.07/12.88)	PCVSWSY.DRVqADNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.17|      11|      14|     413|     424|       5
---------------------------------------------------------------------------
  413-  424 (16.02/11.20)	GQRlPLMAEVSE
  430-  440 (21.14/10.51)	GIR.PSNPESSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.79|      32|     574|     763|     794|       7
---------------------------------------------------------------------------
  763-  794 (61.13/40.23)	LKMLPSHC.......LLPLKIPDACLFRPSWAIPPKIEQ
 1309- 1347 (48.66/30.22)	LKLYAQVCrhhlapyLATLQLDSSLLIPPKYQTPPAAAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.51|      71|    1108|      31|     114|      10
---------------------------------------------------------------------------
   31-  114 (104.73/95.02)	TGQAYKMSDPATRKLieEWQYFYPMVLKKKEESKEEDElgyddDFPVAVeVIVGgvrmvYPSAFVLISQNDIPVPQS..VASAGGH
 1153- 1225 (130.78/81.46)	TGRTWENIQHVQGPL..TWQQFHKMAGRGTYGSEESPE.....PLPIPT.LLVG.....YDKDFLTISPFSLPFWERllLDPYGGH
---------------------------------------------------------------------------











Associated diseases
Disease
breast cancer	PMID:26452386



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28828 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVP
2) CAVGPNRPPTVSQPGFSAGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLEL
3) ECILNRTQSKRSQMSTPTLEEEPASNPATWDFV
4) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTD
5) KDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLH
6) PPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISADRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHP
7) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
614
244
193
546
126
1336
814
663
399
225
612
183
1484
911










Molecular Recognition Features






MoRF SequenceStartStop




NANANA