<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28812

Description Mediator complex subunit 23
SequenceMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDSLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTGLDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNESDIITHFVQSSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVEPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHADRPVTYLYNTLHYYEMHLRERKFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREENPWVPDDTYYCRLIGRLVAPMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGNEVGNALLNVVLKSQPLVPRENITSWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAVSSGSPAPQANQVPVSLPVTQ
Length1370
PositionTail
OrganismOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lorisiformes> Galagidae> Otolemur.
Aromaticity0.10
Grand average of hydropathy0.006
Instability index46.97
Isoelectric point7.19
Molecular weight156441.24
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28812
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.24|      60|      81|     450|     528|       1
---------------------------------------------------------------------------
  450-  525 (94.12/91.96)	SLKLHHEF.LQQSLRNKSLQMNDYK..IALLCnaystnsecftlpmgALVETiYG.............NGIMRIPLPGT.SCLASGSI.TPLPM
  530-  607 (73.12/38.98)	SLTVHAKMsLIHSIATRVIKLAHAKssVALAP...............ALVET.YSrllvymeieslgiKGFISQLLPTVfKSHAWGILhTLLEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.05|      19|     128|     906|     924|       2
---------------------------------------------------------------------------
  906-  924 (38.99/22.42)	KENSPEHW.LQNDWHTKHMN
 1003- 1017 (22.61/ 9.99)	....PVTY.LYNTLHYYEMH
 1037- 1056 (30.45/15.94)	KDNRPQGWcLSDTYLKNAMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     192.58|      45|     682|      38|      89|       4
---------------------------------------------------------------------------
   44-   89 (80.18/66.76)	FRQFWGGLSQESHEQCIQWIVKFIHgQHSPKRISFLYDCL..AMAVET
  766-  801 (58.23/31.64)	YRK.WKSMSNES.....DIITHFV..QSSPP....LFLCLlwKMLLET
  834-  872 (54.17/31.59)	..EFSTSAGGQQLNKCIEILNDMVW.KYNIVTLDRLILCL..AM....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.78|      19|     682|     410|     428|       5
---------------------------------------------------------------------------
  410-  428 (37.90/20.82)	PVPD....INK.PQ.STHAFAMTCI
 1088- 1112 (23.87/10.69)	PFPNcdwrFNEfPNpAAHALHVTCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.73|      40|     127|     170|     209|       7
---------------------------------------------------------------------------
  170-  209 (73.65/45.71)	ILERNACL..LPAY.FAVTEIRKLYPEGK.....LPHWLLGNLVSDFV
  926-  946 (26.47/11.48)	.....................HKKYPE.K.....LYFEGLAEQVEPPV
  955-  995 (37.61/19.56)	IYFGNVCLrfLPVFdIVIHRFLELLPVSKsletlLDH..LGGL.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      32|     339|     348|       8
---------------------------------------------------------------------------
  339-  348 (18.69/ 9.14)	IFFVLFQFAS
  372-  381 (19.45/ 9.79)	LMWVLLQFIS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28812 with Med23 domain of Kingdom Metazoa
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