<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28808

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNIKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSVTSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPIYVPLYELITQFELSKDPNPISLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDTRHSWRFEVCLLFIKRFSDTYVISANNSVPCSYVEMLKTFSNISLYYTFPSLSPTLLPSLCSSLLPPLSYRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCPGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYTQPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTNDDCPPIGTPVRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPAELIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPVLGGDNGETKFKGNSQADTVDFSIISVAGKALGPADLMEHHSGSQSPLLATGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKTDTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSSKMKSSKSEGSSSSKLSGSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSSSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMTGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSVSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHAMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGDGLRAQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDREKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTERPSRLSPDFMMGEEDDDLMDVALIGN
Length1584
PositionMiddle
OrganismOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lorisiformes> Galagidae> Otolemur.
Aromaticity0.05
Grand average of hydropathy-0.681
Instability index54.03
Isoelectric point9.07
Molecular weight169269.17
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
embryonic placenta development	GO:0001892	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation	GO:0060750	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lactation	GO:0007595	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
mammary gland branching involved in pregnancy	GO:0060745	IEA:Ensembl
mammary gland branching involved in thelarche	GO:0060744	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28808
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|    1019.79|      97|     100|    1038|    1134|       1
---------------------------------------------------------------------------
  546-  611 (54.54/10.58)	.........................PAS.......S........P....GyGM..TTGNNPMSGTTTPTNT....FPGGPIT.TL................F..N..MSM...SIKDRH..ES.VGH...............................GEDF...SKVSqnpilTS.L
  616-  716 (91.50/23.70)	GNGGS...................TIGS.......S..P....TP....P.HH..TPPPV.........SS....MAGNTKNHPMlmnllkdnpaqdfstlY..G..SSPlerQNSSSG..S..PRMEMCPGS......NKT..KKKKSSRLPPDKPKHQTE...DDFQ.....RE.L
  719-  827 (93.57/24.43)	MDVDSQnpifdvnmtadtldtphiTPAP.......S...QC.STP....P.TT..YTQPHPQPSIQ.....R...MVRLSSSDSI................G..P..DVT...DILSDI..AE..EASKLPST......NDD..CPPIGTPVRDSSSSGHSQ...STLF.....DSdV
  846-  935 (83.36/20.81)	DAAGSP..................SSDS.......P..TNH.FFP....D.GV..DFNP.DLLNSQSQSG......FGE.....E................YfdE..SSQ...SGDNDD..FK.GFASQALNTlgvpvlGGD..NGETKFK......GNSQA...DTVD.....FS.I
  937- 1031 (90.78/23.44)	SVAG.K..................ALGPadlmehhS..G.S.QS.....P.LL..ATGDLGKEKTQ...KRV...KEGNG........................T..SNS...SLSGPGldSKpGKRSRTPSN......DGK..SKDKPPKRKKTDTEGKSP...SHSS.....SN.R
 1038- 1134 (162.70/48.97)	STGGSK..................SPGS.......S..GRS.QTP....P.GV..ATPPIPKITIQIPKGTV...MVGKPSSHSQ................Y..T..SSG...SVSSSG..SK.SHHSHSSSS......SSS..SASTSSKMKSSKSEGSSS...SKLS.....GS.M
 1137- 1189 (77.02/18.56)	S........................QGS.......S..GSS.QSK....N.S.........S...Q..SG.......GKPGS.SP................I..T....................KHGLSSSS......S........STKM...KPQGKPS...SLMN.....PS.L
 1195- 1293 (114.46/31.85)	SPSHSR..................PPGG.......S..DKL.ASPmkpvP.G....TPPSSKAKSPISSGSGgshMTGTSSS.SG................M..K..SSS...GLGSSG..SL.SQKT.PPSS......NSC..TASSSS.FSSSGSSVSSS...QNQH.....GS.S
 1297- 1368 (82.98/20.67)	S..................................P..SRN.KKP....S.....LTAVIDKL....KHGVV...TSG.PGGEDP................M......DG...QMGVST..NS.SSHAMSSKH......NMS..GGEFQGKREKSDKD...K...SK..........V
 1369- 1463 (93.61/24.45)	STSGS...................SVDS.......S..KKT.SES....K.NV..GSTGVAKIIISKHDG.......GSPSIKAK................V..TlqKPG...ESSGDG..LR.AQMASSKNY......GSPliSGSTPKHERGSPSH.SKS...PAYT.....PQ.N
 1464- 1564 (75.27/17.94)	LDSESE..................S.GS.......SiaEKSyQNS....P.SSddGIRPLPEYSTEKHKKHK...KEKKKVKDKD................R..D..RDR...EKDRDK..KK.SHSIKPESW......SKS..PISSDQSLSMTSNTILSTerpSRLS.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     232.08|      64|      68|     249|     315|       2
---------------------------------------------------------------------------
  216-  244 (31.76/11.66)	...........................GGHLMNIKYYA.SPSDLLDD..............KTTSPIILHE
  249-  315 (99.60/66.88)	RsLGMNASVTIEGTSAMYkLPIAPLIMGSHPVDNKWTP.SFSSVTSANSVdLPA...CFFLKFPQPIPVSR
  320-  386 (100.72/55.91)	K.LQNCTGIPLFETQPIY.VPLYELIT.QFELSKDPNPiSLNHNMRFYAA.LPGqqhCYFLNKDAPLPDGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.21|      32|      66|     437|     468|       3
---------------------------------------------------------------------------
  437-  468 (57.29/32.87)	SWRFEVCLLFIKRFSDTYVISANN...SV..PCSYVE
  477-  503 (31.85/15.09)	SLYYT.....FPSLSPTLLPSLCS...SLlpPLSY..
  505-  537 (41.07/21.54)	CMSIPVTMRAIRRKAET..IQADTpalSL..IAETVE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28808 with Med1 domain of Kingdom Metazoa
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