Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNIKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSVTSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPIYVPLYELITQFELSKDPNPISLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDTRHSWRFEVCLLFIKRFSDTYVISANNSVPCSYVEMLKTFSNISLYYTFPSLSPTLLPSLCSSLLPPLSYRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCPGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYTQPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTNDDCPPIGTPVRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPAELIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPVLGGDNGETKFKGNSQADTVDFSIISVAGKALGPADLMEHHSGSQSPLLATGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKTDTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSSKMKSSKSEGSSSSKLSGSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSSSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMTGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSVSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHAMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGDGLRAQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDREKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTERPSRLSPDFMMGEEDDDLMDVALIGN |
Length | 1584 |
Position | Middle |
Organism | Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lorisiformes> Galagidae> Otolemur. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.681 |
Instability index | 54.03 |
Isoelectric point | 9.07 |
Molecular weight | 169269.17 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl nucleolus GO:0005730 IEA:Ensembl nucleoplasm GO:0005654 IEA:Ensembl |
GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl estrogen receptor binding GO:0030331 IEA:Ensembl LBD domain binding GO:0050693 IEA:Ensembl nuclear receptor coactivator activity GO:0030374 IEA:Ensembl peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl promoter-specific chromatin binding GO:1990841 IEA:Ensembl protein-containing complex binding GO:0044877 IEA:Ensembl retinoic acid receptor binding GO:0042974 IEA:Ensembl thyroid hormone receptor binding GO:0046966 IEA:Ensembl transcription corepressor activity GO:0003714 IEA:Ensembl vitamin D receptor binding GO:0042809 IEA:Ensembl |
GO - Biological Process | androgen biosynthetic process GO:0006702 IEA:Ensembl angiogenesis GO:0001525 IEA:Ensembl animal organ regeneration GO:0031100 IEA:Ensembl brain development GO:0007420 IEA:Ensembl cell morphogenesis GO:0000902 IEA:Ensembl cellular response to epidermal growth factor stimulus GO:0071364 IEA:Ensembl cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl cellular response to thyroid hormone stimulus GO:0097067 IEA:Ensembl embryonic heart tube development GO:0035050 IEA:Ensembl embryonic hemopoiesis GO:0035162 IEA:Ensembl embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl embryonic placenta development GO:0001892 IEA:Ensembl enucleate erythrocyte development GO:0048822 IEA:Ensembl epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA:Ensembl fat cell differentiation GO:0045444 IEA:Ensembl intracellular steroid hormone receptor signaling pathway GO:0030518 IEA:Ensembl keratinocyte differentiation GO:0030216 IEA:Ensembl lactation GO:0007595 IEA:Ensembl lens development in camera-type eye GO:0002088 IEA:Ensembl liver development GO:0001889 IEA:Ensembl mammary gland branching involved in pregnancy GO:0060745 IEA:Ensembl mammary gland branching involved in thelarche GO:0060744 IEA:Ensembl megakaryocyte development GO:0035855 IEA:Ensembl monocyte differentiation GO:0030224 IEA:Ensembl mRNA transcription by RNA polymerase II GO:0042789 IEA:Ensembl negative regulation of apoptotic process GO:0043066 IEA:Ensembl negative regulation of keratinocyte proliferation GO:0010839 IEA:Ensembl negative regulation of neuron differentiation GO:0045665 IEA:Ensembl negative regulation of transcription by RNA polymerase II GO:0000122 IEA:Ensembl peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl positive regulation of gene expression GO:0010628 IEA:Ensembl positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl positive regulation of keratinocyte differentiation GO:0045618 IEA:Ensembl positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl protein import into nucleus GO:0006606 IEA:Ensembl regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl retinal pigment epithelium development GO:0003406 IEA:Ensembl thyroid hormone generation GO:0006590 IEA:Ensembl thyroid hormone mediated signaling pathway GO:0002154 IEA:Ensembl ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl |
Binary Interactions |
Repeats | >MDP28808 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 11| 1019.79| 97| 100| 1038| 1134| 1 --------------------------------------------------------------------------- 546- 611 (54.54/10.58) .........................PAS.......S........P....GyGM..TTGNNPMSGTTTPTNT....FPGGPIT.TL................F..N..MSM...SIKDRH..ES.VGH...............................GEDF...SKVSqnpilTS.L 616- 716 (91.50/23.70) GNGGS...................TIGS.......S..P....TP....P.HH..TPPPV.........SS....MAGNTKNHPMlmnllkdnpaqdfstlY..G..SSPlerQNSSSG..S..PRMEMCPGS......NKT..KKKKSSRLPPDKPKHQTE...DDFQ.....RE.L 719- 827 (93.57/24.43) MDVDSQnpifdvnmtadtldtphiTPAP.......S...QC.STP....P.TT..YTQPHPQPSIQ.....R...MVRLSSSDSI................G..P..DVT...DILSDI..AE..EASKLPST......NDD..CPPIGTPVRDSSSSGHSQ...STLF.....DSdV 846- 935 (83.36/20.81) DAAGSP..................SSDS.......P..TNH.FFP....D.GV..DFNP.DLLNSQSQSG......FGE.....E................YfdE..SSQ...SGDNDD..FK.GFASQALNTlgvpvlGGD..NGETKFK......GNSQA...DTVD.....FS.I 937- 1031 (90.78/23.44) SVAG.K..................ALGPadlmehhS..G.S.QS.....P.LL..ATGDLGKEKTQ...KRV...KEGNG........................T..SNS...SLSGPGldSKpGKRSRTPSN......DGK..SKDKPPKRKKTDTEGKSP...SHSS.....SN.R 1038- 1134 (162.70/48.97) STGGSK..................SPGS.......S..GRS.QTP....P.GV..ATPPIPKITIQIPKGTV...MVGKPSSHSQ................Y..T..SSG...SVSSSG..SK.SHHSHSSSS......SSS..SASTSSKMKSSKSEGSSS...SKLS.....GS.M 1137- 1189 (77.02/18.56) S........................QGS.......S..GSS.QSK....N.S.........S...Q..SG.......GKPGS.SP................I..T....................KHGLSSSS......S........STKM...KPQGKPS...SLMN.....PS.L 1195- 1293 (114.46/31.85) SPSHSR..................PPGG.......S..DKL.ASPmkpvP.G....TPPSSKAKSPISSGSGgshMTGTSSS.SG................M..K..SSS...GLGSSG..SL.SQKT.PPSS......NSC..TASSSS.FSSSGSSVSSS...QNQH.....GS.S 1297- 1368 (82.98/20.67) S..................................P..SRN.KKP....S.....LTAVIDKL....KHGVV...TSG.PGGEDP................M......DG...QMGVST..NS.SSHAMSSKH......NMS..GGEFQGKREKSDKD...K...SK..........V 1369- 1463 (93.61/24.45) STSGS...................SVDS.......S..KKT.SES....K.NV..GSTGVAKIIISKHDG.......GSPSIKAK................V..TlqKPG...ESSGDG..LR.AQMASSKNY......GSPliSGSTPKHERGSPSH.SKS...PAYT.....PQ.N 1464- 1564 (75.27/17.94) LDSESE..................S.GS.......SiaEKSyQNS....P.SSddGIRPLPEYSTEKHKKHK...KEKKKVKDKD................R..D..RDR...EKDRDK..KK.SHSIKPESW......SKS..PISSDQSLSMTSNTILSTerpSRLS......... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 232.08| 64| 68| 249| 315| 2 --------------------------------------------------------------------------- 216- 244 (31.76/11.66) ...........................GGHLMNIKYYA.SPSDLLDD..............KTTSPIILHE 249- 315 (99.60/66.88) RsLGMNASVTIEGTSAMYkLPIAPLIMGSHPVDNKWTP.SFSSVTSANSVdLPA...CFFLKFPQPIPVSR 320- 386 (100.72/55.91) K.LQNCTGIPLFETQPIY.VPLYELIT.QFELSKDPNPiSLNHNMRFYAA.LPGqqhCYFLNKDAPLPDGR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 130.21| 32| 66| 437| 468| 3 --------------------------------------------------------------------------- 437- 468 (57.29/32.87) SWRFEVCLLFIKRFSDTYVISANN...SV..PCSYVE 477- 503 (31.85/15.09) SLYYT.....FPSLSPTLLPSLCS...SLlpPLSY.. 505- 537 (41.07/21.54) CMSIPVTMRAIRRKAET..IQADTpalSL..IAETVE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYFD 2) IKAKVTLQ 3) IRPLPEYSTEKHKKHKKEKKKVKDK 4) KITIQIPK 5) KPSLTAVIDKLKHGV 6) SRLSPDFMMGEEDDDLMDVALI 7) VAKIIISKH | 880 1407 1489 1064 1303 1561 1392 | 886 1414 1513 1071 1317 1582 1400 |
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