<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28807

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLENHQLVQPGGGGAGSSGPVSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFLSVNATDREDSPIMALLLQQFKEDVQDLIFHAKSGKQTRTGTKHKLSDDPCPVESKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPDIPTHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPTQQQPFSKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAANSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPSQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGHP
Length1454
PositionTail
OrganismOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lorisiformes> Galagidae> Otolemur.
Aromaticity0.07
Grand average of hydropathy-0.181
Instability index50.66
Isoelectric point8.81
Molecular weight160682.55
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28807
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     108.39|      18|      30|    1112|    1129|       1
---------------------------------------------------------------------------
 1064- 1084 (22.45/ 7.26)	S.FVPTPPPSSHgisiGP.GASF
 1095- 1110 (27.33/10.59)	SP.YTMVSPSGR.....A.GNWP
 1112- 1129 (37.21/17.35)	SPQVSGPSPATR....MP.GMSP
 1144- 1160 (21.40/ 6.53)	SPR.AGTSSQT.....MPtNMPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.38|      30|      30|     116|     145|       2
---------------------------------------------------------------------------
   85-  112 (23.24/10.29)	..IVQFASRTRQ..LFV....RLLALvkwANDAgKV
  116-  145 (48.83/30.01)	AMISSFLDQQAI..LFVDTADRLASL...ARDA.LV
  147-  178 (46.31/28.07)	ARLPSFAIPYAIdvLTTGSYPRLPTC...IRDK.II
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      31|     246|     275|       3
---------------------------------------------------------------------------
  246-  275 (48.89/31.04)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  276-  309 (45.75/28.59)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      37|    1247|    1261|       4
---------------------------------------------------------------------------
 1247- 1261 (21.47/15.63)	LKCRVALSP.KTNqTL
 1285- 1299 (22.14/11.01)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.55|      19|      25|    1370|    1388|       5
---------------------------------------------------------------------------
 1330- 1357 (19.85/ 7.33)	TQlKWNVqfcltipPSAPPIAPPgTPAV
 1370- 1388 (32.14/17.02)	TQ.KTSV.......PSQEPVSII.VPII
 1396- 1414 (31.56/16.57)	TQ.QADI.......PRQQNSSVA.APMM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.71|      28|      32|     509|     540|       6
---------------------------------------------------------------------------
  509-  540 (41.93/35.32)	IKHLPT..ISSETLQLSNYSTHpignLSKNKLFI
  542-  571 (44.78/26.72)	LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.09|      51|     508|     329|     379|       8
---------------------------------------------------------------------------
  329-  379 (92.74/71.45)	YHAGKCLSLSV.WN...QQ......VLGRKTGTASVHKVTI.KIDE..N...DVSKPLQIFHDPPLP
  812-  878 (62.35/45.06)	YGTTKGSSISIqWNsihQKfhislgTVGPNSGCSNCHNTILhQLQEmfNktpNVVQLLQVLFDTQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.38|      10|      39|    1016|    1025|      16
---------------------------------------------------------------------------
 1016- 1025 (20.03/10.16)	SGAYPLTSPP
 1044- 1053 (17.35/ 7.68)	PGNLHAANSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28807 with Med14 domain of Kingdom Metazoa
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