<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28805

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVELENHQLVQPGAGGAVRGGPASAPAPPPPGAALAAAAATAASPGYRLSTLIEFLLHRAYSELMVLADLLPRKSDVERKMEIVQFASRTHQLFVRLLALVKWAKDVGKVEKCAMISSFLDQQALLFVDAADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPACIRDKIIPPDPVTKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWHLLKLEVLVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIQERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHRVTIKIDENDVSTPLQIFHDPPLPALDSQSVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGSSECLHIFVDLHSGMFQLMLYGLDQNTLDDMEKSVNDDMKRIIPWIQHLKFWLGQQRCKQSIKHLPTTSSETLQLSNYSIHPIGNLSENKLFIKLTRLPQYYIVVEMLEVPSNPTQLSYKYYFLSVNATDQEDSPIMALLQQQFKEDVQDLIFHTKSGKQTRTSTKHKLSDDPCPVESKKTKRSGEMCAFNKVLAHFVAICDTNMPFVRLQLELSNLDIPHQGVQVEGNGFSHALPLLKIPPCQGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFADCPLIGTSTREQGPFRHVYLTYENVLSEPVGGRKIVETFLNDWSSIARLYECVLEYAHSLPDLPAHLNIFSEVRVYNYQKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNSHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAFNKLRTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNTYCIDIYCQSGGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQGAQRRSITEDDNPPSPIGGDMMDSLISQLQPPTQQQPFSKQPGTSGTYPITSPPPSYHSTINQSPSMMHAQSPGTLDPSSPYNMVSPSGQAGNWPGSPQVSGLSPTTFMPGMSPANPSLHSPVPDTSHSPQAGTSSQTMPTNMPPPRKLPQRSWAASSPTILTHSALNILLLPSPMPGLMPGLAGSYLCSPLERFLGSVIMRRHLQRIIEQEMLQLINSNEPGVIMFKTNALKCRVALSPKTNQTLQLKVTPENAGQWKPEELQVLEKFFETKVVGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGMPAVVLISKMLFFLQLTQKTAVPSQEPLSVIVPIIYDMASGTTQQADIPRQQYSCVAARMMVGNILKRFAEMNPPRQG
Length1387
PositionTail
OrganismOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lorisiformes> Galagidae> Otolemur.
Aromaticity0.07
Grand average of hydropathy-0.162
Instability index51.72
Isoelectric point7.59
Molecular weight154103.98
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28805
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     162.25|      31|      31|    1085|    1115|       1
---------------------------------------------------------------------------
  982- 1008 (33.44/13.46)	.DNPPSPIGGDMMDSLISQLQ.........P...PTQQQP.
 1009- 1032 (29.55/10.93)	....FSKQPGTSG.TYPITSP............pPSYHSTI
 1036- 1075 (41.02/18.39)	PSMMHAQSPGTLDPSSPYNMVspsgqagnwPGS.PQVSGLS
 1076- 1094 (28.19/10.04)	P.TTFMPG....................msPAN.PSLHSPV
 1095- 1126 (30.04/11.24)	PDTSHSPQAGTSSQTMPTNMPpprklpqrsWA.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.37|      32|      32|     272|     303|       2
---------------------------------------------------------------------------
  246-  268 (22.05/ 8.57)	....HLLKLEVLVEDKETGDGRAL..VHS......
  272-  303 (56.32/31.91)	NFIHQLVQSRLFADEKPLQDMYNC..LHS.FCLSL
  306-  337 (39.99/20.79)	EVLHS..QTLMLIQER.WGDLVQVerYHAgKCLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.90|      32|      32|      66|      97|       3
---------------------------------------------------------------------------
   66-   97 (52.46/37.34)	LMVLADLLPRKSDVERKMEIVQFASRTHQLFV
   99-  130 (52.44/37.33)	LLALVKWAKDVGKVEKCAMISSFLDQQALLFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.71|      14|      29|     168|     181|       4
---------------------------------------------------------------------------
  135-  151 (17.31/ 6.43)	RLASLARDALV....HarlPS
  168-  181 (25.62/12.79)	RLPACIRDKII....P...PD
  194-  211 (18.78/ 7.55)	QLNQILRHRLVttdlP...PQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.04|      23|      25|     691|     714|       5
---------------------------------------------------------------------------
  691-  714 (34.99/25.47)	QGISEETQKAlDRSLLDCTFRLQG
  718-  740 (41.05/25.58)	RTWVAELVFA.DCPLIGTSTREQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.15|      23|      24|     805|     827|       9
---------------------------------------------------------------------------
  805-  827 (42.28/27.59)	YQKLILCYGTT.KGSSISIQWNSI
  828-  851 (38.87/24.74)	HQKFHISLGTVgPNSGCSNSHNTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     201.86|      72|     106|     478|     563|      11
---------------------------------------------------------------------------
  478-  563 (105.35/97.67)	MEKSVNDDMKRIIPwiqHLKfwLGQQrCKQSIKH......LPTTSSETlqlsnysiHPIGNL.SENKL...FIKL..TRLPQYYIVVEM..LEVPSNPTQ
  587-  672 (96.51/57.36)	LQQQFKEDVQDLIF...HTK..SGKQ.TRTSTKHklsddpCPVESKKT........KRSGEMcAFNKVlahFVAIcdTNMPFVRLQLELsnLDIPHQGVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.86|      12|     457|     892|     905|      13
---------------------------------------------------------------------------
  875-  886 (20.02/ 6.86)	TQAPLNAFNKLR
  894-  905 (21.84/ 6.34)	TQRTNTAYQCFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.68|      24|     163|    1144|    1167|      14
---------------------------------------------------------------------------
 1144- 1167 (47.35/25.90)	PSPMPGLMPGLAGSYLCSPLERFL
 1300- 1323 (45.32/24.44)	PSAPPIAPPGMPAVVLISKMLFFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28805 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QGAQRRSITEDDNPPSPIGGDMMDSLISQLQPPTQQQPFSKQPGTSGTYPITSPPPSYHSTINQSPSMMHAQSPGTLDPSSPYNMVSPSGQAGNWPGSPQVSGLSPTTFMPGMSPANPSLHSPVPDTSHSPQAGTSSQTMPTNMPPPRKLPQRSWAAS
971
1128










Molecular Recognition Features






MoRF SequenceStartStop




NANANA