<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28804

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMRKAGVAHNKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPTTGATGIGMPPRGPGQSLGGMGSLGAMGQLPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQQQQQQQQFQQQQAALQQQQQQQQFQAQQSAMQQQFQAVVQQQQLQQQQQQQQQHLIKLHHQNQQQIQQQQQLQRMAQLQLQQQQQQQQQQVLQAQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYAQQQLKFVRPPMVVPQPQAQPPVQQAQPPVQPQTAVQAAQAAQMVAPGVQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPTPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRKLEEEERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDQQWQYDANPFLQSVHRRMTARLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length720
PositionTail
OrganismOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lorisiformes> Galagidae> Otolemur.
Aromaticity0.03
Grand average of hydropathy-0.748
Instability index90.12
Isoelectric point9.53
Molecular weight79398.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28804
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     567.68|      87|      87|     176|     262|       1
---------------------------------------------------------------------------
  122-  175 (87.49/12.67)	PQTQLQLQQVALQQQQQQQQ..........Q.QQQQQQ.QQFQ...QQQAA..LQQQQQQQQ.FQ.........AQ..............................QS.A.....M...........Q
  176-  262 (160.48/31.64)	QQFQAVVQQQQLQQQQQQQQQHLIKLHHQNQ.QQIQQQ.QQLQRMAQLQLQ..QQQQQQQQQVLQ.........AQPP.....................MQQPQPPPSQA.....LP..QQLQQMHHP
  263-  338 (119.87/21.09)	QHHQPPPQPQQPPVAQNQPSQ..LPPQSQTQ.PLVSQA.QALP..........GQMLYAQQQLKF.........VRPP.....................MVVPQP...QA.....QPpvQQAQPPVQP
  340-  438 (110.80/18.73)	TAVQAAQAAQMVAPGVQVGQSSLPMLSSPSPgQQVQTP.QSMPPPPQPSPQpgQPSSQPNSNVSS.........GPTP................spssfLPSPSPQPSQSpvtarTP..QNF.SVPSP
  443-  552 (89.04/13.07)	TPVNPSSVMSPAGSSQAEEQQYLDKL......KQLSKYiEPLRRMIN.KID..KNEDRKKD..LSkmkslldilTDPSkrcplktlqkceialeklkndMAVPTPPPPPV.....PP..TKQQYLCQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.71|      15|      19|      69|      87|       2
---------------------------------------------------------------------------
   73-   94 (19.27/21.10)	IGMPPrgPGQSlgGMgslGAMG
   99-  113 (32.44/18.26)	SGQPP..PGTS..GM...APHG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28804 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPTTGATGIGMPPRGPGQSLGGMGSLGAMGQLPLSGQPPPGTSGMAPHGMAVVSTAT
2) MLYAQQQLKFVRPPMVVPQPQAQPPVQQAQPPVQPQTAVQAAQAAQMVAPGVQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPTPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQVLQAQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
44
304
232
121
470
302










Molecular Recognition Features






MoRF SequenceStartStop




NANANA