<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28803

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPTPDPLVPSKPVEDRIDSLSQSFPPQFQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVRYKKPLKVSDELVQQYQIKNQYLSAIASDTEQEPKIDPYAFVEGDEEFLFPDKKERQNSEREAAKKHKIEDGTPSVTVLSHEEDAMSLFNPSIKQDTPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSTNGSDEKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLPSGPAMPFIKDGDGSNMDQEYGPAYTPQTHASFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSAEHINGGLKESEKLPDDLILLLQDQCTNLFSPFGAADQDPFPKSGVVSNWVRVEERDFCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQATDGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPSSQPLITPPQMTNTGNSSTPSAPLASAVSSTMTMTSGVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNSAGSMSAQASTVQNGQLGGQQSSALQTAGISGESSSLPTQPHPDVSESTMDWDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLALETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMVIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKQSTHPSLPESHSNLKILGSSSSLASASQYSNEILGFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length1604
PositionMiddle
OrganismOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lorisiformes> Galagidae> Otolemur.
Aromaticity0.08
Grand average of hydropathy-0.351
Instability index50.44
Isoelectric point5.12
Molecular weight175661.33
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28803
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.57|      34|      35|     412|     445|       1
---------------------------------------------------------------------------
  412-  442 (50.58/26.41)	......PAYTPQ....THASFGMPPSSA...PPSNG..GAGIL.PSP
  443-  479 (55.42/29.75)	STPrfpTPRTPR....TPRGAGGPASAQ...GSVKY..ENSDL.YSP
 1374- 1416 (35.57/16.06)	QTS...QLNTPQdtscTH.ILVFPTSASvqvASATYttENLDLaFNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     258.81|      85|     961|     262|     349|       2
---------------------------------------------------------------------------
  170-  274 (118.66/87.72)	TPSVtvlshEEDAMSlFNPSIKQDTPRPTSHARPPSTSLIYD.SDLAVSY.TDLDNLFNSDEdeltPGSKKSTNGSDEKASCKESktgnldplsCISTADLhKMYPT
  275-  363 (140.15/108.08)	PPSL.....EQHIMG.FSPMNMNNKEYGSMDTTPGGTVLEGNsSSIGAQFkIEVDEGFCSPK....PSEIKDFSYVYKPENCQVL.......vgCSMFAPL.KTLPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.25|      18|      18|     901|     918|       3
---------------------------------------------------------------------------
  901-  918 (31.47/15.21)	SQPL..DSSLLSQPNLVAPS
  919-  938 (29.78/13.95)	SQPLitPPQMTNTGNSSTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     248.61|      77|     146|     612|     701|       4
---------------------------------------------------------------------------
  612-  701 (126.69/103.19)	GLKES.EKLPDDLILLLQDQCTNLFSPFGAadqdPFPKSGVVSNWvrVEERD.....FCNDCYLALEHGRQFMDNMSGgkvdealVKSSC...LH.PWSK
  758-  844 (121.93/73.32)	GTDESpEPLPIPTFLLGYDYDFLVLSPFAL....PYWERLMLEPY..GSQRDiayvvLCPENEALLNGAKSFFRDLTA.......IYESCrlgQHrPISR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.69|      30|     962|     480|     557|       5
---------------------------------------------------------------------------
  488-  515 (28.28/29.97)	......PLnSVEPATVPSIPEAHSlyvNL.ILSES
  552-  557 (-0.33/16.39)	EAQYRC.............................
 1516- 1546 (53.74/ 9.45)	QAQYQCPL.FLKQSTHPSLPESHS...NLkILGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.53|      11|     962|     133|     143|       7
---------------------------------------------------------------------------
  133-  143 (21.10/13.64)	IDPYAFVEGDE
 1073- 1083 (21.43/13.97)	IDPFTYENKDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28803 with Med13 domain of Kingdom Metazoa
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