<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28796

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMCSIRTSVAGGMMDLAYVCEWEKWPKSTHCPSVPLACAWSCRNLIAFTTDLRSDDQDLTRVIHILDTEHPWDLYSIASEHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESTVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDPNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSATPRPVDEPAIKRPRTVGPAVHFKAMQLSWTSLALVGIDNYGKLSMLRISPSMGHTLDVSLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQNAALQQVLSTRILAMKASLCRLSPCTVARVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPSSEPDEALVDECCLLPSQLLIPSLDWLPVSDGLVSRLQPKQPLRLHFGKAPMLPGSTTTLQLDGLIRAPGQPKIDHLRRLHLGAYPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCL
Length828
PositionTail
OrganismOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lorisiformes> Galagidae> Otolemur.
Aromaticity0.07
Grand average of hydropathy0.057
Instability index46.56
Isoelectric point7.48
Molecular weight91734.63
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28796
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     611.08|     132|     300|     112|     245|       1
---------------------------------------------------------------------------
   22-  107 (97.49/56.25)	................................................EKWPKSTHCPSV..PLACAWSCR......NLIAFTTD........LRSDDQD.............LTRVIHILD..TEHPWDLYSIASEHSEAITCLEWDqsGSrllSADADGQIK.C
  112-  245 (206.19/137.22)	DHLANSWESTVGSL...VEGDPIvALSWLHNGVKLALHVeKSGASSFGEKFSRVKFSPSL..TLFGGKPME......GWIAVTVSGLVTVSL.LKPSGQV.............LTSTESLCR..LRGRVALADIAFTGGGNIVVATAD..GS...SASPVQFYKVC
  250-  377 (141.82/86.34)	SEKCRIDTEILPSLfmrCTTDPN.....RKDKFPAITHL.KFLARDMSEQVLLCASSQTS..SI.....VE......CW.SLRKEGLPVNNI.FQQISPVvgdkqpmilkwriLSATNDLDR..VSA.VALPKLP......ISLTNTD..LK...VASDTQFY...
  415-  545 (165.58/102.18)	DEPAIKRPRTVGPA...VHFKAM.QLSW....TSLAL....VGIDNYG.KLSMLRISPSMghTLDVSLALRhllfllEYCMVTGYDWWDILLhVQPS.MV.............QSLVEKLHEeyTRQNAALQQVLST...RILAMKAS..LC...RLSPCTVARVC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28796 with Med16 domain of Kingdom Metazoa
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