<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28793

Description Uncharacterized protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFSNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTPRSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRAAWMIKMTCAYYSAISEAKIKKRQSTDPNLEWTQISTRYLREQLAKISDFYHMASNLGDSPVPVPPEVEYAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPVDDDLLKLLLPLMLQYSDEFVRSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCTQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSTNPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTITRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDSQEISPNRPVCVSVACEIAAYSKRRVTARSSGVGSLLQKRIIQVDIQRCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNGEKLVKREKPRELIFPSNYNLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETSGGGDDGQKSRKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSNLSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLSQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVSSLKNDDFTMRGLRRDGNADDIWTAAQNSKPCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMSLFNPSGITNADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWSYNLVGQPQQPGFFLQNQSLTPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAVMQPPPLHAITSQQQLIQMKLLQQQQQQQQQRLLRQAQARPFQQGQPGDQAALFAAQTRPSPQLPQYPGLQPAQTMPQGYTMYGTQMPLQQTPQQQAGGVVLSPSYNSRAYSATHSNPALMERLRQIQQQPSGYVQQQASPYLQPLAGPQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQTTGLEMQQPQQPPQPQQSSQPQSQALGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTSYGHPSHF
Length2155
PositionKinase
OrganismOtolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lorisiformes> Galagidae> Otolemur.
Aromaticity0.07
Grand average of hydropathy-0.430
Instability index58.87
Isoelectric point8.36
Molecular weight241019.83
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28793
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     546.69|     165|     186|    1772|    1955|       1
---------------------------------------------------------------------------
 1708- 1762 (34.87/ 6.83)	..........................IKYEEQHH....LLLYHTHPMPKPRSYYLEPLP...LPP..EEEEEEPTSpvSQEPERKSAEL..S............................................................................................................................
 1782- 1954 (286.35/187.47)	TKSSsrVDEYPQSNIYRV..PPNYSPISSQMMHHPQSTLWSYNLVGQPQQPGFFLQNQS...LTP..GGSRLDPTG..SFVPTNTKQAL..SNMLQRRSGAVMQP..PPLHAITSQQQLIQMKllqQQQQQQQQRLL.......RQAQ..ARPFQQGQPGDQAalFAAQTRpSPQLPQYP..GLQPAQTMPQ...................GYTMY
 1956- 2149 (225.48/125.67)	TQMP..LQQTPQQQAGGVvlSPSYNSRAYSATHSNPALM..ERLRQIQQQPSGYVQQQAspyLQPlaGPQRLN........H....QALqqSPLVGGGIDAVLTSahPNLPSVPLPQDPMRPR...QPQVRQQQRLLqttglemQQPQqpPQPQQSSQPQSQA..LGLQAM.QPQQPLFPrqGLQQTQQQQQtaalvrqlqkqlssnqpqqGVTSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.67|      23|     251|     554|     584|       2
---------------------------------------------------------------------------
  554-  576 (39.05/16.06)	ESISS.ASLAGS...SLPV.FQNVLLRF
  812-  835 (33.29/11.71)	EQITSfASGTSY...HLPL.AHHIQLIF
  865-  891 (25.34/ 7.68)	LLLKS.SSLAGSyttGLCVcIVAVLRRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.59|      16|      26|    1138|    1156|       3
---------------------------------------------------------------------------
 1138- 1156 (24.52/23.59)	HLFRAPQAcflSQATGKPF
 1166- 1181 (27.07/15.31)	HLLAAAHN...SIEVGAVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.54|      42|     151|     490|     535|       4
---------------------------------------------------------------------------
  490-  535 (64.12/55.17)	ANQNKDsQEISPNRPVCVSV.......ACEIAAYSKRRvtaRSSGVGSLLQKR
  639-  687 (67.42/45.20)	AGENAD.EHYSKDHDVKMEIfspmpgeSCENANTSLGR...RMSVNGEKLVKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.99|      26|     151|     894|     922|       5
---------------------------------------------------------------------------
  894-  919 (46.39/25.37)	CLILNPDQTAQVFEGL...CGVVKHV..VNP
  940-  965 (28.20/11.17)	CSHLRS.KFGDLFSNLssaCSKVKQT..I..
 1046- 1072 (38.41/18.80)	CTVLSSEWLG.VLKAL...CCSSNHVwgFND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.95|      15|      20|    1351|    1368|       6
---------------------------------------------------------------------------
 1351- 1368 (19.91/23.95)	AEMNNlldNIAKATIEVF
 1372- 1386 (26.04/19.39)	ADLNN...NSSNSGMSLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.95|      73|     160|    1415|    1498|      10
---------------------------------------------------------------------------
 1415- 1498 (107.81/88.80)	GVWLVAPLIARLPTSVQGrvlkaaGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSL......VLTClkgqdEQREGLLTSLQNQV
 1578- 1656 (112.14/70.13)	GVLINGTLASDLSNASPG......GSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLpkqtcdVITC.....EPMGSLIDTKGNKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28793 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGFFLQNQSLTPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAVMQPPPLHAI
2) QQQQQRLLRQAQARPFQQGQPGDQAALFAAQTRPSPQLPQYPGLQPAQTMPQGYTMYGTQMPLQQTPQQQAGGVVLSPSYNSRAYSATHSNPALMERLRQIQQQPSGYVQQQASPYLQPLAGPQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQTTGLEMQQPQQPPQPQQSSQPQSQALGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTSYGHPSHF
3) RSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMH
1830
1898
1728
1881
2155
1812










Molecular Recognition Features






MoRF SequenceStartStop




NANANA