<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28787
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MAAQELGRWGEYGPRPPARLGARASQEPATALGTVGTMDLAYVCEWEKWPKSTHCPSVPLACAWSCRNLIAFTTDLRNDDQDLTRMIHILDTEHPWDVHSINSGHSEAITCLEWDQSGSRLLSADADGQIKCWNMVDHLANSWESRVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFSEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSALPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDPHRKDRFPAITHLKFLARDMSEQVLLCASSQTSSLVECWSLRKEGLPVNNIFQQIAPAVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHVVHRLSLQTMAVFYSSATPRSVDEPAIKRARAAGPSVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSMGHALEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPAMVQSLVERLHEEYTRQKAALQQVLSTRILAMKASLCRLSPCTVTRVCDYHTKLFLVAISSTLKSLLRPHFLNTPDSPGDRLTEICAKITDADIDKVMINLKTEEFVLDTNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLVPTLDWLPVSDGLVSRLQPKQPVRLHFGKAPMLPGSTPTSQLDGLARVPGQPKIDHLRRLHLGAYPTEGCKACARCGCVTMLKSPNKATAVKQWEQRWTKNCLCGGLWRKMPLSFS |
Length | 865 |
Position | Tail |
Organism | Cavia porcellus (Guinea pig) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae>
Cavia.
|
Aromaticity | 0.07 |
Grand average of hydropathy | 0.013 |
Instability index | 45.71 |
Isoelectric point | 8.26 |
Molecular weight | 95418.65 |
Publications | PubMed=21993624
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
|
GO - Biological Function | catalytic activity GO:0003824 IEA:InterPro
thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP28787
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 146.20| 47| 188| 456| 507| 1
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456- 507 (79.11/60.51) FKAMQ..LSWT.........SLAlvgidNHGK.....LSMLRISPSMGHALEVGLALRHLLFLLEYCM
635- 697 (67.09/41.06) LQALQqlLQWVgdfvlyllaSLP.....NQGSplrpgHSFLRDGTSLGMLRELMVVIRIWGLLKPSCL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 93.84| 28| 188| 108| 156| 2
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108- 135 (53.96/67.17) AITCLEW...DQSGSRLL..SADADGQIKCWNM
304- 336 (39.88/13.78) AITHLKFlarDMSEQVLLcaSSQTSSLVECWSL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 130.14| 36| 370| 207| 243| 4
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207- 243 (52.01/30.69) VTVSGLVTvSLLKPS..GQVLTSTESLCRLRGRVALADI
548- 570 (26.71/10.15) ..............S..TRILAMKASLCRLSPCTVTRVC
579- 616 (51.42/26.47) VAISSTLK.SLLRPHflNTPDSPGDRLTEICAKITDADI
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