<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28786

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMENFTALFGAQTDPPPPPTALSFGPGKPPPPPPPPPGGGPGTAAPPTAATAPPGADKSAAGCGPFYLMRELPGGTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPITGTMLSGFRLHTGPLPEQCRLMHIQPPKKNKHKHKQSRAQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKSRHSPDHPGMGSSQASSSSSLR
Length243
PositionHead
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.05
Grand average of hydropathy-0.991
Instability index65.98
Isoelectric point9.80
Molecular weight26101.54
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP28786
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.92|      16|      16|     189|     204|       2
---------------------------------------------------------------------------
  189-  204 (27.85/11.30)	PETPSDSDHKKKKKKK
  208-  223 (26.07/10.21)	PERKRKKKEKKKKKSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      57.45|      14|      40|      67|      80|       4
---------------------------------------------------------------------------
   67-   80 (23.15/11.49)	LMRE........LPGG.TELTGS
   85-   99 (18.14/ 7.59)	THYN........LEQAyNKFCGK
  100-  121 (16.15/ 6.04)	KVKEklsnflpdLPGM.IDLPGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28786 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPIT
2) MENFTALFGAQTDPPPPPTALSFGPGKPPPPPPPPPGGGPGTAAPPTAATAPPGAD
3) TMLSGFRLHTGPLPEQCRLMHIQPPKKNKHKHKQSRAQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKSRHSPDHPGMGSSQASSSSSLR
108
1
147
145
56
243










Molecular Recognition Features






MoRF SequenceStartStop




1) DSDHKKKKKKKEEDPERKRKKKEKKKKKSRHSPDH
2) FGPGKPP
3) MENFT
194
23
1
228
29
5