<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28783
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAASAEGDSQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPNLQLSISLCHSSNDKKSQKSASEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSSEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL |
Length | 651 |
Position | Head |
Organism | Cavia porcellus (Guinea pig) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae>
Cavia.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.429 |
Instability index | 55.74 |
Isoelectric point | 7.06 |
Molecular weight | 72829.09 |
Publications | PubMed=21993624
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
stem cell population maintenance GO:0019827 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP28783
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 175.05| 50| 110| 280| 330| 1
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280- 330 (83.70/55.90) PLPKSKP.GsPHW...QTKLEAAQNVLL........CKEIFAQLSREAV..QIKSQIPHIVVKNQ
393- 443 (70.26/42.20) PHPASAPfG..HK...RMRLSGPQ.AFD........KNEINSIQSSEGLleKIIKQAKHIFLRSR
462- 503 (21.09/ 7.33) ..........AHWsniNDVYESSVKVLItsqgyeqiCKSIQLQLNIGVE..QIR...........
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 214.48| 70| 339| 175| 248| 2
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175- 248 (111.22/86.02) QENKLQrDFnsELLRLRQHwKLRKVGD..KILG..DLSYRSAGSLFPHH..GTFEVIKNTDIDLDKKI.....PEDYCPLDVQIP
517- 597 (103.27/64.65) QEQELQ.DF..LLSQMSQH.QVHAVQQlaKVMGwqVLSFSNHVGLGPIEsiGNASAITVASPSGDYAIsvrngPESGSKIMVQFP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 72.90| 23| 244| 1| 27| 4
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1- 27 (33.42/25.05) MSGVRAVRISIesacEKQVQEVGLDGT
251- 273 (39.48/20.16) LEGSAYIKVSI....QKQAPDIGDLGT
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