<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28782

Description Cyclin dependent kinase 19
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQNQHQQPTAPAPQAAAPPQAPPPQQSSTQTNGTTGGVAAGMGATAAGLQHSQDSGLSQVPPNKKPRLGPSGASSGGPVMPSDYQHSSSRLTYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
Length457
PositionKinase
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.08
Grand average of hydropathy-0.739
Instability index57.60
Isoelectric point8.55
Molecular weight51665.76
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28782
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     303.18|      95|     151|      12|     118|       1
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   12-  118 (144.38/133.23)	ERERVE.DLFEYeGCKVGR.GTYGHVYKARRKDGKDEKEYALKQIEG..TGISMSACREIALLRelKHPNVIALQKVFlshsdRKVwllfDYAEHDLWHIIKFHRASKANK
  165-  263 (158.80/111.10)	ERGRVKiDIWAI.GCIFAElLTSEPIFHCRQEDIKTSNPFHHDQLDRifSVMGFPADKDWEDIR..KMPEYPTLQKDF.....RRT....TYANSSLIKYMEKHKVKPDSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.17|      16|      34|     366|     381|       2
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  366-  381 (27.52/17.76)	GVAAGMGATAAGLQHS
  401-  416 (30.65/20.61)	GASSGGPVMPSDYQHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.69|      16|      17|     275|     290|       3
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  275-  290 (27.35/15.74)	DPTKRITSEQALQDPY
  294-  309 (29.34/17.39)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.90|      14|      14|     418|     431|       6
---------------------------------------------------------------------------
  418-  431 (25.59/17.27)	SRLTYQSSVQGSSQ
  434-  447 (25.31/17.01)	STLGYSSSSQQSAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28782 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQNQHQQPTAPAPQAAAPPQAPPPQQSSTQTNGTTGGVAAGMGATAAGLQHSQDSGLSQVPPNKKPRLGPSGASSGGPVMPSDYQHSSSRLTYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
309
457










Molecular Recognition Features






MoRF SequenceStartStop




1) NKKPRLG
2) QYHPSHQAHRY
3) SRLTYQSSV
4) TLGYS
392
447
418
435
398
457
426
439