<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28781

Description Mediator of RNA polymerase II transcription subunit 13
SequenceAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLGGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLRKKEESKEEEELGYDDDFPIAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVTSAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVTGESGGMQSATSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTHSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTLSQPGFSAGPSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTSGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSALDDRTVLVGQRLPLMAEVSETALYCGIRSSNAESSDKWWHSFRLPPSDDAEFRPPELQGERCDAKMEVNTESTALQRLLAQPNKRFKIWQDKQSQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTHLTEFKMEVEDGLGSPKPEEIKDFSYVHRVPTFQPFMGSSMFAPMKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQNTFLPQMEGARKTQETPMSLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHAWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPVCKVLRDGIMRVGKTVAQKLTDELVSEWFSQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPATAQGHTMPGNTGPLASNSGSAAPQAGSAFNPTTSNGSSANPAASTSTSGSSVPPVSSSASAPGINQMSTTSSSGFSGSVGGQNPGTGASSTDRTQGNISCGGDTEPGQGSSQPSQDGQESVTDRERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDCTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQVVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRKSKVSPRKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAEHLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2186
PositionMiddle
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.07
Grand average of hydropathy-0.407
Instability index57.82
Isoelectric point5.71
Molecular weight240551.48
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28781
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.19|      27|      28|    1589|    1615|       1
---------------------------------------------------------------------------
  285-  317 (33.32/14.18)	.QQGLGSVKDPSN.C.GMPLTPPT.......SPeqavtgesGG
 1006- 1039 (34.83/15.25)	SNSGAGVLPSPAT.P.RFSVPTPR.......TPrtprtprgGG
 1040- 1072 (25.34/ 8.53)	TASGQGSVKYDSTdQGSPASTPSTtrplnsvEP..........
 1591- 1619 (42.70/20.82)	QNPGTGASSTDRT.QGNISCGGDT.......EP......gqGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     137.98|      28|      28|    1522|    1549|       2
---------------------------------------------------------------------------
  418-  440 (32.14/12.91)	....PTLSQPGFSAGPSSSSLPPPASS.
  515-  535 (33.02/13.52)	MNLNPMDSPHSP.....ISPLPPTLS..
 1522- 1545 (34.62/14.63)	....PLASNSGSAAPQAGSAFNPTTSNG
 1546- 1568 (38.20/17.11)	SSANPAASTSTS.....GSSVPPVSSSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      28|    1102|    1126|       3
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 1102- 1126 (51.64/36.98)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1129- 1157 (36.91/23.99)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.41|      17|      28|    1996|    2018|       4
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 1996- 2018 (27.36/24.64)	SPNNDdmfvdlPFPDDMDNDIGI
 2027- 2043 (32.04/14.86)	SPNSS......PVPSPGSPGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.62|      14|      28|     336|     350|       5
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  336-  350 (22.76/17.85)	HSpKRSGKIPPKLHN
  366-  379 (25.86/14.34)	HS.KRSQMSTPTLEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.52|      28|      31|    1831|    1861|       6
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 1832- 1861 (45.49/36.07)	IVNI.ALPNRSRKSKVSprKIGLQKLWEWCI
 1863- 1891 (47.03/24.47)	IVQMtSLPWRVVIGRLG..RLGHGELKDWSI
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.94|      23|      32|    2063|    2085|       7
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 2063- 2085 (39.36/23.11)	PEELKQQPL....ALGYFVSTAKAEHL
 2094- 2120 (36.57/20.90)	PQAQNQCPLflkaSLHHHISVAQTDEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.18|      33|      37|      29|      62|       8
---------------------------------------------------------------------------
   29-   62 (56.10/47.93)	DDPILLSFIRC.LQANLLCVWRRDVKPDCKELwIF
   66-   99 (54.09/39.20)	DEPNLGGVIHHeLQVVEEGLWENGLSYECRTL.LF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.64|      18|      22|     924|     944|       9
---------------------------------------------------------------------------
  936-  955 (24.20/16.38)	LLPLKiPDAcLFR..PSWAIPP
  959-  978 (26.44/ 8.09)	QLPMP.PAA.TFIrdGYNNVPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.51|      33|      36|     832|     864|      10
---------------------------------------------------------------------------
  832-  855 (36.59/16.96)	.............TVADLQRM..FPTPPSLEQHPAFSPV
  856-  881 (40.13/19.39)	MNYKDGISS...eTVTALGMM..........ESPMVSMV
  890-  927 (41.79/20.52)	MEVEDGLGSpkpeEIKDFSYVhrVPTFQPFMGSSMFAP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.00|      20|      36|    1388|    1416|      11
---------------------------------------------------------------------------
 1388- 1415 (26.40/34.45)	GGHRDvayivVCpenEALLEG....AKTFFRD
 1426- 1449 (30.60/13.37)	GQHKP.....VC...KVLRDGimrvGKTVAQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.15|      16|      36|     540|     558|      12
---------------------------------------------------------------------------
  540-  558 (24.47/21.44)	GQETESLDPPSvpvNPALY
  578-  593 (27.68/14.91)	GQRLPLMAEVS...ETALY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.89|      30|      37|    1270|    1301|      13
---------------------------------------------------------------------------
 1270- 1301 (44.48/35.48)	DEALVRSATVHAWphSNVLDI.SMLSSQDVVRM
 1310- 1340 (51.41/33.08)	QDAIQKKRTGRTW..ENIQHVqGPLTWQQFHKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.10|      23|      27|    1717|    1743|      14
---------------------------------------------------------------------------
 1721- 1743 (43.93/32.17)	IQYLKSM..AFSVYCQCR...RPLPTQI
 1745- 1772 (29.17/10.27)	IKSLTGFgpAASIEMTLKnpeRPSPIQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.24|      79|     111|     610|     690|      17
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  610-  690 (131.97/97.24)	SFRLPPSDDA....EFRPPELQGERCDAKMEVNTESTALQRLLAQPNKRFKIWQDKQSQ...MQP.LHFLDPLpLSQQPGDSLGEVNdP
  716-  802 (118.27/77.31)	SLKKNKSEDGfgtkDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQvtdLAPsLHDLDNI.FDNSDDDELGAVS.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.79|      12|     298|     103|     114|      23
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  103-  114 (23.47/13.69)	HNLLERCLMDKN
  404-  415 (23.32/13.56)	HKLLKRCAVGPN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.69|      19|      20|    1674|    1693|      25
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 1674- 1693 (31.02/22.92)	NFWLLSLMRCyTEMLDNLPE
 1697- 1715 (34.67/20.23)	NSFILQVVPC.QYMLQTMKD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28781 with Med13 domain of Kingdom Metazoa
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