<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28777

Description Mediator of RNA polymerase II transcription subunit 13
SequenceIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPQKLASHVVDRVWQECNLNRAQNKRKYSASSGGLTEEEIPDKVACWDFVEATQRTSCSCSRHKNLKPRNSGQGQAPSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRISISDDVGMDADSASQRLVISAPDSQVRFSNLRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVADEGVTKTPSTPQSQHFYQMPTPDPLVPAKPMEDRIDSLSQSFPPQFQETVEPTVYIGTAVNLEEDETNKAWKYYKVPKKKDVEFLPPQLPGDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYISAVASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSSSVKQDAPRPSSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSVTGSDDKANCKESKTGNLDPLSCISKLLKILCCNYGSMDTTPGGTVLEGNSSSIGAQFRIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKSLPSQCLPPIKLPEDCVYRQSWTVGKLELLPSGSTMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATIPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDFGKEAEKRFEALRATSAEHINGGLKESEKLPDELILLLQDQCTNLFSPFGVSDQDPFPKIGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKNSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLHGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGPTASKKLSEKIVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVTPTSQSLVTPPQMTNTGSANTPSATLVSTASSTMTMTSGVAISSSVATTSSTLTTSSSSSSSNLNSGASSNKLPSFPPFGSMNSSVTGSMSAQTSTVQGSQLGGQQSSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYEDKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTPDDLDPDIINILPASPTASPVHSPGSHYPHGGDTGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2123
PositionMiddle
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.08
Grand average of hydropathy-0.404
Instability index51.43
Isoelectric point5.46
Molecular weight234178.61
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl
GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl
GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28777
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.20|      42|      62|     435|     478|       1
---------------------------------------------------------------------------
  435-  478 (66.83/40.63)	EKSEKPQKRPLTPfhHRISISDD..VGMDADSASQRLV.ISAPDSQV
  498-  542 (73.37/38.47)	EMANSPQPPPLSP..HPCDVADEgvTKTPSTPQSQHFYqMPTPDPLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.20|      63|      67|     867|     931|       2
---------------------------------------------------------------------------
  867-  931 (109.32/51.21)	MfAPLKSLPSQCLPPIkLPEDCVYR.QSWTVGKLELLPSGSTMPFIKEGDGSNMDQE.YGPAYTPQT
  937- 1001 (107.88/44.44)	M.PPSSAPPSNSGAGI.LPSPSTPRfPTPRTPRTPRTPRGAGGPASAQGSVKYENSDlYSPASTPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.83|      43|      56|    1446|    1495|       3
---------------------------------------------------------------------------
 1446- 1488 (69.14/38.00)	NTGSANTPSATLVSTASSTMT.M..TSGVAI.....SSSVATTSSTLTTSS
 1502- 1545 (64.35/43.69)	NKLPSFPPFGSMNSSVTGSMSaQ..TSTVQG.....SQLGGQQSSALQTAG
 1881- 1927 (46.34/23.78)	.TGSVFGRSTTLNMQTSQLNT.PqdTSCTHIlvfptSASVQVASATYTT..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.59|      19|      56|    1335|    1353|       4
---------------------------------------------------------------------------
 1333- 1351 (33.03/24.79)	LH.....................GAKSFFRDLT.AIYESCR
 1352- 1368 (22.70/14.22)	LG.....................QHRPISRLLTdGI...MR
 1369- 1408 (17.86/ 9.28)	VGptaskklsekivaewfsqaadGNNEAFSKLK.LYAQVCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     379.10|     119|     432|     709|     854|       5
---------------------------------------------------------------------------
  717-  854 (181.07/137.92)	MSLFSssVKQDAPRP.....SSHARPPSTSLIYDSDLAVSYTD..LDNLFNSDEDE.......LTPGSKKsvtgSDDKANCKEsktgnlDPLSCISKLLKILCCNYGSMDTT.PGGtvLEGNSSsiGAQFR.......IEVDEgfcSPKPSEIKDFSYVY
 1151- 1291 (198.03/98.46)	FSPFG..VSDQDPFPkigviSNWVRVEERDCCNDCYLALEHGRqfMDNMSGGKVDEalvknscLHPWSKR....NDVSMQCSQ......DILRMLLSLQPVLQDAIQKKRTVrPWG..VQGPLT..WQQFHkmagrgsYGTDE...SPEPLPIPTFLLGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.56|      56|     255|    1690|    1749|       6
---------------------------------------------------------------------------
 1690- 1749 (87.99/54.24)	GLAMETALKSPD..RPECIRLYTPPFILAPVKDKQTEL...GETfGEaGQKYNVLFvgYCLSHDQ
 1943- 2003 (91.57/44.37)	GMGIFDLLDTPDdlDPDIINILPASPTASPVHSPGSHYphgGDT.GK.GQGTDRLL..STESHDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.74|      37|     716|     356|     394|       7
---------------------------------------------------------------------------
  356-  394 (58.68/41.46)	CNLNRAQNkRKYSASSGGLTEEEIpDKVA.CWDFV.EATQR
 1075- 1113 (58.06/32.24)	CGFSAVMN.RKFGNNSGLFLEDEL.DIIGrNTDFGkEAEKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.28|      30|     440|    1412|    1443|       8
---------------------------------------------------------------------------
 1412- 1443 (49.72/38.39)	GPYLASQPldSSLLSQPNLVTPTSQ.SLVTPPQ
 1826- 1846 (27.53/12.65)	..........SCLLSRRNL.QSLSK.RLKDMCR
 1849- 1877 (44.03/26.86)	GISAADSP...SILSAC.LVAMEPQgSFVIMPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.40|      25|     314|     282|     312|      11
---------------------------------------------------------------------------
  282-  312 (35.43/35.00)	HQVPaSTRDpamssVTLTPPTSPEEVQTVDP
  590-  614 (46.97/27.26)	YKVP.KKKD.....VEFLPPQLPGDKFKDDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28777 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSCSRHKNLKPRNSGQGQAPSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRISISDDVGMDADSASQRLVISAPDSQVRFSNLRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVADEGVTKTPSTPQSQHFYQMPTPDPLVPAKPMEDRIDSLSQSFPP
2) GSTMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
3) SPVHSPGSHYPHGGDTGKGQGTDRLLSTESH
4) SVATTSSTLTTSSSSSSSNLNSGASSNKLPSFPPFGSMNSSVTGSMSAQTSTVQGSQLGGQQSSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGD
5) VTPTSQSLVTPPQMTNTGSANTPSATLVSTA
397
905
1971
1476
1431
560
990
2001
1578
1461










Molecular Recognition Features






MoRF SequenceStartStop




NANANA