<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28771

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMENHVFQKAKTRDEYLSLVARLIIHFRDIPQLQLQQVALQQQQQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQALQAHPPIQQPPLQQPQPPPSQALPQQLPQMHHPQHHQPPPQAQQPPVAQNQPSQLPPQSQSQPLVSQAQALSGQMLYAQPQLKFVRAPMVVQQPQVQPQVQQQPAVQTAQAAQMVASGVQVSQSGLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVLCTRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length666
PositionTail
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.04
Grand average of hydropathy-0.809
Instability index94.21
Isoelectric point9.22
Molecular weight74827.83
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28771
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.22|      33|      36|     331|     365|       2
---------------------------------------------------------------------------
  236-  268 (44.05/ 6.60)	QPSQLPPQSQSQP..LVSQAQALSGQMLYAQPQLK
  331-  365 (59.17/13.65)	PPPQPSPQPGSQPnsNVSSGPAPSPSSFLPSPSPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     155.26|      33|      36|     124|     156|       3
---------------------------------------------------------------------------
  108-  138 (49.78/ 8.67)	QQQQQQQQF.....QAQQ..samQQQFQAVVQQQQQLQ
  139-  176 (55.98/10.75)	QQQQQQQHLIKLHHQNQQqiqqqQQQLQRMAQLQLQQQ
  177-  209 (49.50/ 8.58)	QQQQQQQQALQAHPPIQQ...ppLQQPQP..PPSQALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.32|      24|      27|     441|     467|       4
---------------------------------------------------------------------------
  441-  467 (37.15/28.82)	LSKMKSLLDILTDPSkrcP..LKTLQK..CE
  470-  497 (37.17/19.71)	LEKLKNDMAVPTPPP...PpvLPTKQQdlCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      27|     624|     634|       5
---------------------------------------------------------------------------
  624-  634 (23.12/16.29)	NPFLQSVHR.CM
  652-  663 (18.67/11.57)	NTWAQSIHQaCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.78|      25|      64|     210|     234|       6
---------------------------------------------------------------------------
  210-  234 (52.49/19.67)	QQLPQ...MHHPQHHQPP..PQAQQPPVAQ
  277-  293 (30.54/ 7.36)	QQ.PQ...V......QPQ..VQ.QQPAVQT
  373-  402 (31.74/ 8.03)	ARTPQnfsVPSPGPLNTPvnPSSVMSPAGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.08|      18|      22|     560|     577|       7
---------------------------------------------------------------------------
  560-  577 (32.84/19.09)	VARLDPKFLVNLDPSHCS
  585-  602 (32.24/18.61)	ICKLDDKDLPSVPPLELS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.75|      15|      23|     498|     512|       8
---------------------------------------------------------------------------
  498-  512 (25.60/16.32)	PLLDAVLA.NIRSPVF
  522-  537 (23.14/14.07)	PAMTAIHGpPITAPVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28771 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QLKFVRAPMVVQQPQVQPQVQQQPAVQTAQAAQMVASGVQVSQSGLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
2) QQQQQQALQAHPPIQQPPLQQPQPPPSQALPQQLPQMHHPQHHQPPPQAQQPPVAQNQPSQLPPQSQSQPLVSQAQALSG
266
179
416
258










Molecular Recognition Features






MoRF SequenceStartStop




NANANA