<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28770

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETNFEGDDGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDSIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQEIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSTPGPLQPKQQVPLPPVPPSGPTLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQATPPTLPPGPPGAPKAPPASQPNLVSTVVPGPGLAPAAAQPGAPSMAGAVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGAVGASGAAGQPQAPGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPGQMLLSGGPRGPVPQSGLQPSVMEEDILMDLI
Length747
PositionUnknown
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.05
Grand average of hydropathy-0.242
Instability index60.56
Isoelectric point8.31
Molecular weight78246.90
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28770
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     438.93|      66|      66|     565|     630|       1
---------------------------------------------------------------------------
  189-  241 (55.10/ 8.04)	.PAL.RLLFEK...AAPPAMLEPLQPPadvSQDPRHMVLVRGLV.LP..VGG..............GSTPGPlQP
  251-  294 (64.27/10.59)	PPS.GPTLS.....AAPQQS.L...PP...VP.PQ....Y.......QVPGNLSAAQVAAQ..NAVEAA....KN
  296-  341 (77.34/14.23)	KAGLGP................RFSPI...NPLQQAA...SG.VGPPFSQAT...PPTLPP..GPPGAPKAP.PA
  460-  506 (48.67/ 6.25)	.TTLGPLF.......RNSR.MVQFHFT...NKDLESLKGLYRIMGNGFA.GCVHFPHTAP...............
  568-  630 (120.54/26.27)	...LGPILEDQ...ARPSQNLLQLRPP...QPQPQGAVGASGAAGQPQAPGTTQAPPGAPQ..GPPGAAPGP.PP
  631-  688 (73.01/13.03)	P.G..PILRPQnpgANPQLRSLLLNPP...PPQT.G.VPP......PQASLHHLQPPGAPAllPPPHQSLGQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.40|      19|      21|     350|     370|       2
---------------------------------------------------------------------------
  350-  368 (36.59/ 8.34)	VVPGPGLAPAAAQPGAPSM
  372-  390 (35.82/10.14)	VAPGGVSGPSPAQLGAPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.81|      31|     111|      39|      69|       3
---------------------------------------------------------------------------
   39-   69 (58.00/34.88)	YLLPAIE..YFNGGPPAETNFEGDDGGTQYSLV
  151-  183 (49.81/28.88)	YLLPAVEstTYSGYTTESLVQEIGERGIHFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.48|      26|     283|     415|     454|       5
---------------------------------------------------------------------------
  415-  449 (28.90/50.18)	PASVDANTKLTRslpcQVYVNHGenlKTEQwpQKL
  528-  553 (46.57/24.07)	PYDQSGFVNGIR....QVITNHK...QVQQ..QKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28770 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSTPGPLQPKQQVPLPPVPPSGPTLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQATPPTLPPGPPGAPKAPPASQPNLVSTVVPGPGLAPAAAQPGAPSMAGAVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGAVGASGAAGQPQAPGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPGQMLLSGGPRGPVPQSGLQPSVMEEDILMD
232
545
391
745










Molecular Recognition Features






MoRF SequenceStartStop




NANANA