<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28764

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGTAKNINFNPAKISSNFSSIIAEKLRCNTLPDTGRKRPVHQKDNFWLVTTRSQSAINTWFTDLAGTKPLTLLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSENKGKKRQVVDPFTEWTQIITKYLCEQLQKMAEYYRPGPAGSGGCSSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGDDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVTSHSSHVISTQSTSALPTTPAPQPSTSNTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGGSTCGEALKPGDVCRVSSWAQDVLRLDLISLYPTLPYLSLCSFGLQISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMACEGKGSPSPEKLDVEKEVKLPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGSSGSRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNMNSLLENIAKATIEVFQQSAETGSSSGSMANNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLASSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYNQVHQIVKNWRDGQYLDDYKPKQLMHEALKLRLNLVGGMFDTVQRSTHQTTEWAVLLLEVIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGGMEENKRAYMNLVKKLQKELGEHQSDSLEKVRQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEACSTVFSCPWPFFSNLKALAGSSLRSPSGFENCLWGFDLKSKVQLGVVAQACNPRTERLRQRLPMSSSSSSSSTQLHQQQQQQSAPPQPQPQSQPQVAVQHHLIFCFLFPPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRF
Length1828
PositionKinase
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.07
Grand average of hydropathy-0.289
Instability index52.73
Isoelectric point6.18
Molecular weight203235.59
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28764
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.71|      20|      23|    1787|    1807|       1
---------------------------------------------------------------------------
 1787- 1807 (30.78/22.27)	QFQRQgLQQTQQQQQTAALVR
 1808- 1827 (36.93/21.89)	QLQQQ.LSNTQPQPSTNIFGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.54|      14|      24|    1561|    1574|       2
---------------------------------------------------------------------------
 1561- 1574 (24.86/14.77)	LLEVIISGTV..DMQS
 1585- 1600 (20.68/11.13)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.69|      24|      24|     695|     718|       3
---------------------------------------------------------------------------
  695-  718 (40.83/22.86)	EGK.GSPSPEKLDVEKEVKLP.PKEK
  720-  745 (33.87/17.68)	EGTlGVLYDQPRHVQYATHFPiPQEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.33|      16|      17|     639|     655|       4
---------------------------------------------------------------------------
  639-  655 (23.45/18.36)	DDPADDpERKEAEGSSS
  659-  674 (28.88/16.96)	EDPGLS.ESMDIDPSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.08|       8|      23|    1683|    1692|       5
---------------------------------------------------------------------------
 1683- 1692 (15.43/13.31)	CPWPFfsNLK
 1708- 1715 (18.65/ 8.53)	CLWGF..DLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.19|      13|      22|     349|     363|       6
---------------------------------------------------------------------------
  349-  363 (21.63/19.53)	LLMCPQhrPLVFGLS
  370-  382 (28.56/17.48)	LLCCPS..ALVWHYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.54|      11|      23|    1076|    1086|       7
---------------------------------------------------------------------------
 1076- 1086 (20.72/12.61)	AILCAELTGYC
 1099- 1109 (21.82/13.76)	ALCCSSNNGTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      17|    1028|    1040|       8
---------------------------------------------------------------------------
 1028- 1040 (25.11/14.48)	ENPAA.HTFTYTGL
 1046- 1059 (21.03/10.97)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.33|      18|      22|    1219|    1239|       9
---------------------------------------------------------------------------
 1222- 1239 (28.73/18.77)	FAVLKAVFVLGDAELKGS
 1241- 1258 (31.60/13.11)	FTVTGGTEELPEEEGGGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.24|      17|      24|    1463|    1479|      10
---------------------------------------------------------------------------
 1463- 1479 (27.80/17.34)	KERDRQKQKSMSLLSQQ
 1490- 1506 (28.44/17.93)	KGQDEQREGLLTSLYNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      14|      17|    1329|    1343|      11
---------------------------------------------------------------------------
 1329- 1343 (22.26/16.90)	HRLLDNEDgENPQRQ
 1346- 1359 (25.76/14.57)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.66|      17|      17|    1734|    1750|      12
---------------------------------------------------------------------------
 1734- 1750 (26.99/13.01)	LRQRLPMSSSSSSSSTQ
 1751- 1767 (31.66/16.67)	LHQQQQQQSAPPQPQPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28764 with Med12 domain of Kingdom Metazoa
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