<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28754

Description Uncharacterized protein
SequenceMTSRTPIGVHPRPPQRTISSSTLPPAQRPPPQRALSQQLFPSSPVRKDSALSDASSDSIDHFQAQTHGQSTTQAQNHARLVTTPRRAGSRLRLELSNIDPPHGNSALLSTTASATASAPTSAASSPQSHTTSRVPSMADGGDVGASSPTPTRASAADLDNDNIPFPMPKRRLPASQTYSKLLSKRLEAPPRPAPAFKKDGRPKPWTVEVPKDAPRYPPAEKRPPPTSSDRMTKDGDPFSRGLYSGNADFFPWHGTKDIKHHEDDWTPEAITKGTWDRGTQNETGTARMTISPAIKQKPGMSALSTIFMGILNQRRLRGHVTAPSTFKPPPRVTLTDTKREVWMRDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKSVPTERAVWLAKCVGANEIRAFKRKGAPGGGAFAIAGEFKWIRDWTVFVEQFIESTTFSFGEPDWKVKVTYAIRLATSFYAEQLLDRDHYLDWITSGLEHSPQSKLPMWILIAQICWADILRSRKYGRRLVYALLGHLHTIYIHPDKDILIQLSSQLSTLLASLVRDKSDSFIDPSLWSKYRDALDASLPRDDKASRDAYSHINTRNGQVSVTSNTSPLAGRPQLVRLLDATLLSQINRDLPQKCWATGDDKTDIVKTTVDWATSFYRPGLARVYIAANLIRVWASLRIDVTGAILEHMDTIPADDEGRKQMAYHLVVELIRTGQFSVTQYTKWLMARGGCSHPSEVDSDEAPCTTRLLVHLPVHYLTEDQKDDRSSLLRRAANYSVIEEADDIHNALVCVSHTLGLPVQDNDMSGGRKPIPLRKLLPMIIHSSRALRCAVGIHLRDGVMRLNKSVQAMSQRLFSAIRTILEATQDFYALCEILKFCSRTTNIEVLASCVDTLNLNLQVFYAQGTAERLFIVFLERLKAINQEQGLVSRPLLASLCSLSRRMPNRQEISKQLAHELMLSDRNNATDACSPVSDNNMTNPLSGADGEVSEQIEKLLASGNSIDHPTMNRLFAYIIRRLELGWAKMDDNRRIHASLLTRLRLFDAQHFDKLMSDWVGRVRLMKKRERLHAVFPLLIITDALPVSFLFGPTSLTQASASQGDAESAGAAPLDLSSPGAATFHQELLQLTLSKLPDDTDLSQEEVYRFGICQQSIHFSHHKGLLSLIRHAIIEYADLRAGNGSVKLPLDDVAYRNRILDALQLLVVMHTADVTEAFSVQKVHPGAFHLMHEIISNLFKQHGATKDGSSLTAPYDEILRQTNELTMPFCQIKLNMDLSVTPPRQTEGQDAPQSVSQYDLFAQAMDRAIGAQNVMWTTMLPCLSKDISRHLQSQARQRFLALVPASTQLKDAESIQGALPSNNNLYLAEKLLGVIEAIVVGQPPPPTAQLTMALANKLSDLVDLVVAPRAAEDKKGGMLSAVVEHWIPMLLKFVLLHSVSQEPLSASVMTTSVQGKLLMPPHHEARAHTVLTLCRLLLGLETLPSQVAGGGLLQHLFDVAAVLADGLPDDLRLHCAKSVLVVPGMMPTLHTSSDFRLYYIFSIPPPTVMDGVMLAHRDRTAVPHSSASRGMGAMYGIRPLPHERLSPYVIRRWELLSEPTPNVGVNDTSLNLSLFQAIRIH
Length1601
PositionKinase
OrganismHypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma atroviride)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.252
Instability index46.89
Isoelectric point9.02
Molecular weight177396.14
Publications
PubMed=21501500

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28754
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.60|      36|      97|     888|     936|       1
---------------------------------------------------------------------------
  888-  926 (50.19/42.72)	AQG......TAERLFIVFLERLKaINQEQGLVSRPLLASLcsLSR
  982- 1023 (56.41/37.86)	ASGnsidhpTMNRLFAYIIRRLE.LGWAKMDDNRRIHASL..LTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     331.76|      88|      96|    1334|    1428|       2
---------------------------------------------------------------------------
 1334- 1424 (131.01/85.97)	SIQGAL..PSNNNLYlAEKLLgVIEAIVVGQPPPPTAQLTMALANKLSDlVDLVVAPRAAEDKKGGMLSAVV....EHWIPMLLKFVLLHSVSQEPL
 1432- 1517 (129.61/77.36)	SVQGKLlmPPHHEAR.AHTVL.TLCRLLLGLETLPSQVAGGGLLQHLFD.VAAVLADGLPDDLRLHCAKSVL......VVPGMMP..TLHTSSDFRL
 1520- 1579 (71.14/36.86)	.......................IFSI.....PPPTVMDGVMLAHR.....DRTAVPHSSASRGMGAMYGIRplphERLSPYVIRRWELLS...EP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     375.51|      93|     103|     129|     225|       3
---------------------------------------------------------------------------
   61-  128 (89.15/37.35)	HFQAQThgQSTTQ....AQNHARLVTTPRRAgSRLRL...ELSNIDPPHGNSAL.LSTTASATAS.........APT.............................SAASSPQS
  129-  225 (157.21/78.77)	HTTSRV..PSMAD....GGDVGASSPTPTRA.SAADL...DNDNIPFPMPKRRLPASQTYSKLLSKRLEApprpAPAFK.KDGRPKPWTVEVPKDAPRY......PPAEKRPPP
  226-  330 (129.14/57.20)	TSSDRM..TKDGDpfsrGLYSGNADFFPWHG.T.KDIkhhEDDWTPEAITKGTWDRG.TQNETGTARMTI....SPAIKqKPGMSALSTIFMGILNQRRlrghvtAPSTFKPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.51|      29|     108|     435|     466|       7
---------------------------------------------------------------------------
  435-  466 (48.96/37.08)	SFGEPD.WKvkvTYAIRLATSFYAEQLLDRDHY
  547-  576 (48.55/29.27)	SFIDPSlWS...KYRDALDASLPRDDKASRDAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.85|      39|     160|     493|     542|       8
---------------------------------------------------------------------------
  493-  542 (48.20/59.97)	WADiLRSRKYGrrlvyALLGHLHTIyiHPDKDILIQLSSQlstLLASLVR
  660-  698 (69.65/45.41)	WAS.LRIDVTG.....AILEHMDTI..PADDEGRKQMAYH...LVVELIR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28754 with Med12 domain of Kingdom Fungi
Unable to open file!