<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28753

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPKPRSQALQSGNTPAGLLSANPTLEQAHRPALSSPLQTTTPSSQDHDFKAESNIKTTAQSLLYEKLITAVSLTISTAFCRRTGAIPLNYRTILISPTTYSAQPHGVAIGRPQILGTFRVYLTTTGALVIGISLTKCKGILSLDDTAASSLAPAGYSVLAAPFGIMTATQNFVPGDGGLSSLAQTPMTHFFSFRNGLDGQESLWKQACQRFLDFRGIAASTLGGCLWVNLLVPKSKSADSKGDYRSSGATSSFTLPWPRRLCFRKKNVDASSASRVVDTMLSGHEESHDPLGNAKGWHNSIAEREEKIKRAAERAAAIPKDSQPQPADSKTPKPSGLSPVAFQRPNTATAGIMYPTPPDGVQQPSGVTPSMDGTFSSPGNPLSAPIMPEADITMQNEPVGGVGLDQSPNVAEPKRRRSDNLLGDTDNVLGGDVGGDIFDDNDITEADFNFFDEKPGDLDLDIAMGDLPSSEMAAPTSAPASALPAVISLPPPPPPPPPPQKETAVFAKPELKHARSQNEDAARRNRGDVRVTPAKRESSPFDPHAVFKRVKASLKKPKYDSSISAQPHWRNAKVFESLDFDPAIPMISKKYEKGGFFDLSALTKVERMEKANGNVPSVPETDYLKRHGKLNRKPRDRSTARHTIGKQYFAMEPPILTTSPMKLDGSISDREDGNMESDQDDSSYTSDEPGSPHKASIRLMHGDDDIMSQITSLRDCDIEEPDHQLAMELPRLSRSDISGVSLSQLFLDPEPLLLDMGLSDEDVIQIAQIVADQAATGSLDIFNASDFEPATLSASEKRSDLSIHARDAFYTLEGIITHFFEDAMPVRLKGLLDIQDLPILSQFIPRHVNGREGNSETMRPSNLYQIPSPHLEVQRADTKLSVLPSAISFWESLGLSPCSGSKNINAICVFPGWSGMGDNVKAFMDRVKSIYELLKLGTFEVMPLGEDVEAGLLPYEVDRITTSPDATVTRHGSAMVECMEALRGVFSNLAITETNFVIYFVYSPENPGTIIESCTAFQRFYELYQKVLASRKEAPQNELVLQLVSTDVLSSPSALVITQTSDLVRLCIETYDRCTLFGGPMPAPAIRLEQLLPRIIDFKLTTTPSASLIRENSCIHVAYSQSVDERWVTAAWTDDRGNQQATAAYCMGRKGKSPSRNMNEIANEIWETTLELMSSWRVLWRVIITKCGPMPQHEVDFWVDLARTEIHAKVTLVLLTVDSNPSLQLLPPAIKLPAPVAALHTPVSTPQPSMQSPEPVATPATPAANAAAATPSNDGTGTAETESDEILVDVSDQTWGAITGHRLSNSSSILEVQLSLMSGYLIKRTGLRLEDPPVVMEVNLIYTETTPRVHEPLLREMLGYFRGLGTLARARGVVDKEGDVRPWHVAAAEKAVRALYLLM
Length1399
PositionKinase
OrganismHypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma atroviride)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.294
Instability index49.98
Isoelectric point5.43
Molecular weight152293.80
Publications
PubMed=21501500

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28753
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.04|      19|      22|     146|     167|       1
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  123-  141 (30.43/12.27)	TTTGALV.IGIS.LTKCKGIL
  146-  166 (23.61/21.72)	TAASSLApAGYSvLAAPFGIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.50|      15|      18|    1228|    1242|       2
---------------------------------------------------------------------------
  468-  484 (20.56/ 6.70)	PSSEMAAPTSAPASalP
 1228- 1242 (27.47/11.50)	PAIKLPAPVAALHT..P
 1248- 1262 (28.47/12.19)	PSMQSPEPVATPAT..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.99|      15|      15|      29|      43|       3
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   29-   43 (28.72/15.75)	HRPALSSPLQTTTPS
   47-   61 (22.09/10.37)	HDFKAESNIKTTAQS
   90-  101 (20.18/ 8.82)	YRTILISP...TTYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.82|      22|     204|     574|     600|       4
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  574-  600 (34.46/33.85)	VFESLDFDPAIPMISKKYEkggffDLS
  781-  802 (38.36/23.32)	IFNASDFEPATLSASEKRS.....DLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.46|      17|      18|     178|     194|       5
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  178-  194 (31.48/21.88)	GLSSLAQTPMTHFFSFR
  199-  215 (32.98/23.31)	GQESLWKQACQRFLDFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.51|      17|      18|     343|     359|       6
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  343-  359 (32.33/16.36)	QRPNTATAGIMYPTPPD
  393-  409 (23.19/ 9.45)	TMQNEPVGGVGLDQSPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.57|      15|      18|     432|     448|       7
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  432-  448 (21.81/21.08)	DVGGDIfdDNDITEADF
  453-  467 (25.76/16.12)	EKPGDL..DLDIAMGDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.06|      16|      23|    1299|    1314|       8
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 1299- 1314 (27.29/13.92)	TGHRLSNSSSILEVQL
 1325- 1340 (28.77/15.03)	TGLRLEDPPVVMEVNL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.91|      10|      15|     664|     673|       9
---------------------------------------------------------------------------
  664-  673 (18.09/ 9.20)	DGSISDREDG
  681-  690 (18.82/ 9.87)	DSSYTSDEPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.06|      11|      22|     533|     544|      10
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  533-  544 (18.98/15.57)	PaKRESS.PFDPH
  557-  568 (18.08/ 8.87)	P.KYDSSiSAQPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.64|      16|      19|     485|     502|      12
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  485-  502 (28.56/19.51)	AVisLPPPPPPPPPPQKE
  504-  519 (27.08/12.19)	AV..FAKPELKHARSQNE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28753 with Med13 domain of Kingdom Fungi
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