<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28740

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNNLPDEIVHITQGFVPLSLLLTRLAQSTHNMVQDKIAELAKMPLPAAATNGNTNYTQSAPDDTSSENLRKKAALLHFTQDMHAKWVKALVIVEWSRKASMVSKLIDLKFHLDQQRILYDTALDSIINVKRDLTYARMPSPDLKTALQVLSTGTAPWMPDLQYIEPPPLTTEEQLKGIGDLDTLLSLRLNLDDFDKIPYQFRNYTIGSGRVTFKVAGEFEVDLTIADEDFEKQFWFIDFRFAFRPAALSLPESLRAPLENCVNEALAKDGLTGCYQFLHEYVLTTKINELKRQALQLSRTSWTGTLAVEPLNRALSIQYWTSRSTATGLKNWIIVAINSGRKQGGRIDPKASSFLAAKWYRDGKEVKDVEIEVNTENLSAEALLKDVVGRHIEYILSSIHSGMLAAPRFKNRETGVVLNISKTDPVASCLNLQVGYGGTVSLLIEPTSGAFAMKPHSKFSIQPELQLNNGKNPTEDGVAFLEHLRCAIIEDELGRMGTARGWSVRKAPINIDELKSITKMRRWSRTLWLQHGGWGSAWFVGVILSLEGDEWWLLETDPAQTNGASKFHTRLPLNKGAPHLSGTFWDNLNLFAGGMITQSVDMRELHRRKVKCQSNGSIDLSLPQQVRMPSIEVALSAIFPTMMQEYTDEIASQNHIAFGLNEDPQVLALLRSKAGVSSSTREPWAENMVAINFKGVHSESRHEETSEGGHTTTHSLVCTSDVVIRVRRPTRFLALKGMVDRDVSYNPQRGEFILQVQRRVTEPVFDILKSRIKAIDRFVNFLEAMERAKGLIISESITLKGVVFCYSSPLPAPSNEETVAPPPARELWRVKMDLSSEDIDIHMEKDNPHVRVIDLARNLASTEGGIGLLMAWLPMSLHAMKALVQLDVQWTELFKKGQGQLDFSMKSMTWINLKYKNLATSQAGEKTKRNISIDVRMKARRGEGWWHAWRSTTNAVADDFDQALKAVWEGKGNNWLGLTTGAAAQSNEAVMDMLCAIDGAIRGVIHASPSISSGGVKGEVITLD
Length1024
PositionTail
OrganismHypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens) (Trichoderma virens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.08
Grand average of hydropathy-0.242
Instability index42.23
Isoelectric point6.95
Molecular weight114366.61
Publications
PubMed=21501500

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28740
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.51|      47|     275|     550|     693|       1
---------------------------------------------------------------------------
  551-  602 (79.19/200.63)	WWllETDPAQTNG.ASKFHTRLplnKGAPHLSGTFWDNLNLFAGGMITQSV.DM
  945-  993 (79.31/18.07)	WW..HAWRSTTNAvADDFDQAL...KAVWEGKGNNWLGLTTGAAAQSNEAVmDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.06|      20|      25|     446|     470|       2
---------------------------------------------------------------------------
  446-  465 (36.86/26.27)	PTSGAFAMKPHSKFS.IQPEL
  473-  493 (31.20/11.50)	PTEDGVAFLEHLRCAiIEDEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.00|      55|     653|     110|     168|       8
---------------------------------------------------------------------------
  110-  168 (88.26/68.96)	FHLDQQRIlydTALDSIINVKRDLTYAR....MPSPDLKTALQVLSTgTAPWMPDLQYIEPPP
  765-  823 (88.73/56.41)	FDILKSRI...KAIDRFVNFLEAMERAKgliiSESITLKGVVFCYSS.PLPAPSNEETVAPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.55|      20|     719|     171|     203|      10
---------------------------------------------------------------------------
  175-  196 (28.34/34.73)	LKGIGDLDtlLSLRLNLDDFDK
  213-  232 (33.22/ 8.38)	FKVAGEFE..VDLTIADEDFEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28740 with Med14 domain of Kingdom Fungi
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