<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28735

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSSGDGPPPLSLRPFPVADQKPKNLAEFIARVNAQPGGFRSVTEEKLREDLKNSESSDGAADHDEDMSEAGAENEVAEKDPNVARMEVLKNIDIAGNIALLTLDSMSLLLSKQNPTQAGLTLSQQLRDMVGIGTLGADRLNDSNSTPAKTKDQEAIAMGWTIMEINKTRDSAEEAAAFLEKEISAESKYWEDIISVRKAGWSVCKVPQERHTLGVKFGFSEAAPEFKNNGLAPMRRGDNSSTDLDFGRLGGVSEALVVTYERDGKIIGRSTTRSASEDGSLESRVLEARNTIFSQELWHELTKESRSLAAYDVKPEGKKLTCQADDAMKITFELLPLESCPSHDEHLPENGLAEKTSMVLHILLSYAHRYNELMRIRPVPPHISRSSRQQSYALLRPILARTMYLKNIEESMQYVGALVKTLQKAGLPSSVILRTTQASASDPNSRGPNQLSASQTLVRNLLQTQDFTLEITILPEISFIIRARAFSFPVTATYYYILLPPSSPLPTMCPPWAEGYPSVQTLGDYLRTVVVRVLTNHFHEGEDAGELALSLSSTAENGTSNTWKWSVGGASETRSARDVIRSLVVAAQELA
Length591
PositionHead
OrganismHypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens) (Trichoderma virens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.369
Instability index54.29
Isoelectric point5.34
Molecular weight64908.48
Publications
PubMed=21501500

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28735
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.44|      13|     363|     178|     226|       1
---------------------------------------------------------------------------
  159-  171 (23.78/34.12)	GWTIMEINKTRDS
  200-  212 (25.65/21.62)	GWSVCKVPQERHT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.59|      13|     314|      81|      93|       4
---------------------------------------------------------------------------
   81-   93 (23.68/15.27)	PNVARMEVLKNID
  397-  409 (23.91/15.48)	PILARTMYLKNIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.17|      38|     166|     255|     292|       5
---------------------------------------------------------------------------
  255-  292 (62.96/42.53)	ALVVTYERDG...KIIGRSTTRSASEDGSLESRVLEARNTI
  417-  457 (58.22/38.77)	ALVKTLQKAGlpsSVILRTTQASASDPNSRGPNQLSASQTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.65|      13|     166|     336|     348|       6
---------------------------------------------------------------------------
  336-  348 (27.59/17.58)	PLES.CPSHDEHLP
  504-  517 (26.06/16.18)	PLPTmCPPWAEGYP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28735 with Med17 domain of Kingdom Fungi
Unable to open file!