<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28729

Description Uncharacterized protein
SequenceMTSRTPIGVHPRPPQRTLSSTSLPSAQRPPPQRALSQQLFPSSPVRKDSALSDASSDSVDPVQAQGQGQGQNTILGQGHGRLVTTPRRVGSRLRLELSNIDPPGSAASASISASASASVSAASSPQSHTTSRGPSMADAADVDGSSPAPSRASAADFDNDNHPLPMPRRRPPTSQTYPELSRRLAAPPRPAPALKKDGRPRPWTVEVPKNAPRYPSAEKKPNATGGDPFSRGLFSGHADFFPWHGGNGKHHEDDWSPEAIQKGTWDRGNQNETSTARMTISPAIKQKTGLGALSTIFMGVLNQRRHRGHVTAPSTFKPPPRVTLTDTKREVWMKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKSVPTERAVWLAKCVGANEIRAFKRKGAPGGAFAIAGEFKWIRDWTVFVEQFIESVSSAFGEPDWKAKLTYAIRLATNLYAEQLLDRDHYLDWITSGLEHSPQSKIPMWILIAQICWADILRSRKYGRRLVYSLLAHLNTIHIHPDKDILIQLSSQLSTLLVSLIRNNPDSFIDPGLWPKYKDALEAFLPRDDKAGREAYHYINIRNGQLSITSTASPLVGRPQLVRLLDATLLSQIDRDLPQKCWATGDDKVDIVRTTVDWATSFYRPGLARVYIAANLIRFWSSLRVNVTGAILEHMDTIPVGDGGRKQTVYQLVTELVRTGQFSVPQYLKWLVARGACSQPSEVDSDDAPCTTRLLVHLPIRYLTEDQKDDRANLLRRAANYSTVEEASDIGNALMCVNHTLGLPVQGDAMAGRNPIPLRKLVPRIVSSSKALQTTVGLHLRETVLRLVKSVQPVSLRLFSAIRTILEATQDFYALCDVLKLCSRTTNIEVLASCVDTVNLNLQVFYAQGGAERLFNIFFERLKAINQEQGLVSRPLLASLCFLSRRMPSRQEIAKYLAHELAQSDRNNATDACSPISDNMVNPPSGADGEVSEQIEKLLASGNSIDHPTMNRLFGYIIRRLEAGWAKMDDNRRIHASLLTRLRLFDSQHFDKLMSDWVGRVRLLKSRKRLDAVFPLLIITDALPVSFLVGPASLTRAAAPGDADAAAPPDLTSPGAVTYLQELLHLILSNLPADTDLSQEEAYRFGIYQRAIQFNHYKGLLSLIRHAVVEYADLRARDGNANLPLDDGTYRERVLGALRLLVVMHTADVTEVFSAKNIPPAGFRLAHEIVSNLFQQDGDQSAASAAPYDHILRLANELTMPFCQIKLNMDLSIPPPRQAENEDGQPQSLSQFDLFAKAMDRAIEAQNIMWTTMLPCLSEDISRHLQSQARSRFLDLVPTSSKNPSPSNVHDAVANSNNLYLAEKLLGVIEAIVVGQQPPNTAQLTSVLADRLSDLVELVVAPKDHEDKMKGLLIPIIEHWLPMLLRFVLLHSVSSEPLSASVMTTTPQGKLVLPPHHEARAHTVLTLCRLFLALEALPSQVVGASLLQQVFDVTTVLADGLPDDLRLHCAKSILLVPGMMPNLHSSSDARLFYIFSVPQLTATDGLMLAHREKTTMPHSTAARGMGAMYGIGPTSQERLSPFVLRRWELLSEPTPNVGVNDTSLSLGLFEAIRLH
Length1584
PositionKinase
OrganismHypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens) (Trichoderma virens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.227
Instability index49.47
Isoelectric point8.97
Molecular weight174747.71
Publications
PubMed=21501500

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28729
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     243.59|      86|     106|    1258|    1363|       1
---------------------------------------------------------------------------
 1259- 1361 (128.05/113.66)	SQF.DLFAKAMDRaieaQNIMWTTMLPCLSEDISRHLqsqarsRFLdLVPTSSKNPSPSNV..............HDAVANSN....NLYLAekllgvIEAI...VVGQQ.PPNTAQLTSVLADRL
 1362- 1470 (115.54/71.99)	SDLvELVVAPKDH....EDKMKGLLIPIIEHWLPMLL......RFV.LLHSVSSEPLSASVmtttpqgklvlpphHEARAHTVltlcRLFLA......LEALpsqVVGASlLQQVFDVTTVLADGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.75|      55|      96|     536|     592|       2
---------------------------------------------------------------------------
  536-  592 (94.52/60.85)	SFIDPGLWPKYKDA.LEAFLP..RDDKAGREAYHYINIRNGQLSITSTASPLVgrPQLVR
  630-  687 (88.23/50.88)	SFYRPGLARVYIAAnLIRFWSslRVNVTGAILEHMDTIPVGDGGRKQTVYQLV..TELVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.50|      25|     144|      23|      51|       3
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   23-   51 (42.03/24.14)	LPSAQRPPPqralSQQLFP......SSPVRKDSAL
  164-  194 (43.47/17.84)	LPMPRRRPP....TSQTYPelsrrlAAPPRPAPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.22|      15|      28|    1027|    1041|       4
---------------------------------------------------------------------------
 1027- 1041 (23.92/15.24)	VGRVRLLKSRKRLDA
 1058- 1072 (25.29/16.62)	VGPASLTRAAAPGDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.45|      32|     143|    1075|    1110|       5
---------------------------------------------------------------------------
 1075- 1110 (52.39/44.84)	AAPPD........LTSPgavtYLQELLHLILSNLP...ADTDLSQEE
 1214- 1256 (46.05/29.27)	AAPYDhilrlaneLTMP....FCQIKLNMDLSIPPprqAENEDGQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.04|      28|     317|     429|     480|       8
---------------------------------------------------------------------------
  430-  458 (47.37/68.52)	WkAKLTYAIRLATNLYAE.QLLDRDHY....LDW
  994- 1026 (43.67/12.49)	W.AKMDDNRRIHASLLTRlRLFDSQHFdklmSDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.37|      22|     206|     201|     222|      20
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  201-  222 (42.32/26.65)	RPWTVEVPKNAPRYPSAEKKPN
  408-  429 (40.05/24.81)	RDWTVFVEQFIESVSSAFGEPD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28729 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FFPWHGGNGKHHEDDWSPEAIQKGTWDRGNQNETSTARMTISPAI
2) MTSRTPIGVHPRPPQRTLSSTSLPSAQRPPPQRALSQQLFPSSPVRKDSALSDASSDSVDPVQAQGQGQGQNTILGQGHGRLVTTPRRVGSRLRLELSNIDPPGSAASASISASASASVSAASSPQSHTTSRGPSMADAADVDGSSPAPSRASAADFDNDNHPLPMPRRRPPTSQTYPELSRRLAAPPRPAPALKKDGRPRPWTVEVPKNAPRYPSAEKKPNATGGDPFSRG
240
1
284
232










Molecular Recognition Features






MoRF SequenceStartStop




1) RLRLEL
92
97