<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28728

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceDVTGHGLIVREHGVIEPPIIQKPRSQGLQSSGTPTSLLSTTSTLEQAYRPALSSPLQTTAPISQDPDPKAEKPKTTSTAQRPLYEKFIASVLLTISTTFCRRVGAVPLNYRTVLLSPTAYNAQPHGVAIGKPQILGTFRAYLTTTGALMISLALTKCRGILSLDDAVPSSLAPSGYSVLAAPFGIMTATQNFVPGDGGLTSLAQTPMTQFFSFRGGLDGQESSWKQACLRFLNFRGITASTLGGCLWVNLLVPKPKTADTRGDHRSSSASSSFTLPWPRRLCFRKKNVDASSTSRVVDAVLSGHEESHDPLGNAKGWYSSITDREEKLKRAMERAANIPKDPQPQSVESKTPKPSGLSPVALQRPNTATAGIMYPTPPDGVHQANGVTPSIDGTLSSPGNPLSAPVVAEADASIQNEPTGGDSVDQSPEFADSKRQRSDSNLLSGDGENIFGGDIGRDMFDDNAITEADFNFFDEKPGDMDADIPMADMPSSEMALPPPPQPVEETVIPVETAPPPLAPTPTSLPLHPPVTPSRVVFAKPELKHARSQNEDPTRRSRGEIRVTPIKRESSPFDPHAVFKRVKASLKIPKYDSTTSSQPAWRKAKIFESLDFDPALPMINKKYERGGLFDLSALSKVEKMEKPNIDLRAVPETDYLKRHGKLNRKPRERPITRSTMAKQYSVLEPQMSTTSPMKLDGSISGEDSSVESDQDDSSYTSDEPGSPHKASIRLINADDDILSQITSLRDCDIEEPDHQLAMELPRLSKSDMTGVPLSALFSDPEPLLLDMALNDDDLIQIAQIVTEQAATGGLDIFRASDFETATLSASQKRQELLTHSRDSFHTLEEIVAQFFGDTMPMRLKGLLDIQDVPLLSHFQPRQIPGREGNPEAIRPSNLYQIPSPHLEVQRADTKLSVLPSAVSFWESLGLSPSSGSKNINAICVFPGWPGMGDNVKTFLDRIKSVYEFLKLGTFEVMHLGADMEAGLLPYEIDRITTSPDATVTGHGSAMIESMEVLRGVFTNLAITETNFVIYFVYSPDNPGTIIESCTAFQRFFETYQKILATRKEPPQNELVLQLVSADLLSSPSALVVTPTSDLVRLCIETYDRCTLFGGPMPAPAIRLEQLLPRIIDFKLTTNPSASLIRENSCIHVAYAQSVDERWITAAWTDDRGNQQATASYCMGRKGKSPSRNMNEIANEIWETTLELISAWKVLWRVIITKCGPMPQHEMDFWVDLARTEINAKVTVALLTVDTNPSLQLLPPVVRLPPPSAALHTPASTPQPSAFSPEPPTPATPAREANMTAATPSGDGGASNAGAGDADLDAILTDVTDQTWGAIAGHRLSNSMSILEVHPALISGYLIKRTGIRVEDAPTVMEVNLVYTEAMPRVHEPLFREMLGYFRGLGTLARARGVVDREADVRPWHVAAAEKAARALYLLM
Length1434
PositionKinase
OrganismHypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens) (Trichoderma virens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.303
Instability index47.57
Isoelectric point5.44
Molecular weight156232.37
Publications
PubMed=21501500

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28728
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     256.78|      77|     141|     568|     653|       1
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   10-   52 (29.74/ 9.12)	.......................................REHGVIEP.........PIIQKPRSQGlqssG.TPtslLSTT.STLEQAYRPAL.........
  568-  653 (117.98/88.99)	ESS.....PFDPHavfkrvKASLKIPKYDSTTSSQ.PAWRKAKIFESlDFDPA..LPMINKKYERG....GlFD...LSAL.SKVEKMEKPNIDLrAVPETD
  711-  792 (109.06/61.21)	DSSytsdePGSPH......KASIRLINADDDILSQiTSLRDCDIEEP.DHQLAmeLPRLSKSDMTG......VP...LSALfSDPEPLL...LDM.ALNDDD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.66|      16|      18|     228|     243|       2
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  228-  243 (29.59/20.86)	CL..RFLNFRGITASTLG
  245-  262 (25.07/16.35)	CLwvNLLVPKPKTADTRG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     312.37|      96|     141|     291|     390|       3
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  291-  390 (155.97/75.00)	SSTSRVVDAVLSGHEES..HDPLGNAKGWYSSITDREEKL..KRAMERAANIPKDPQPQSVESKTPKPSGLSPVALqrPNTATAGIMYPTPPD.GVHQAngVTPS
  433-  533 (156.41/67.15)	SKRQRSDSNLLSGDGENifGGDIGRDMFDDNAITEADFNFfdEKPGDMDADIPMADMPSSEMALPPPPQPVEETVI..PVETAPPPLAPTPTSlPLHPP..VTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.88|      59|     478|     813|     900|       4
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  842-  900 (108.10/114.47)	LEEIVAQFFGDTMPMRLKGLLDIQDV.P.LLSHFQPRQIPGR.EGNPEAIRPSNLY..QIPSPH
 1322- 1385 (78.77/39.68)	LTDVTDQTWGAIAGHRLSNSMSILEVhPaLISGYLIKRTGIRvEDAPTVMEVNLVYteAMPRVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.15|      19|      19|     135|     153|       5
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  135-  153 (31.92/17.58)	LGTFRAYLTTTGALMISLA
  154-  172 (32.23/17.83)	LTKCRGILSLDDAVPSSLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.94|      37|     591|      56|      98|       6
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   56-   98 (55.41/50.59)	LQTTAPISQDPDPKAEKPKTTSTAQRPlYekfiaSVLL.TISTT
  115-  133 (22.82/ 7.03)	LSPTAYNAQPHGVAIGKPQ.........................
  667-  689 (25.71/11.18)	...............ERPITRSTMAKQ.Y.....SVLEpQMSTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.20|      19|      20|     186|     204|       8
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  186-  204 (34.81/21.78)	MTATQNFVPG.DGGLTSLAQ
  207-  226 (33.39/20.56)	MTQFFSFRGGlDGQESSWKQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28728 with Med13 domain of Kingdom Fungi
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