<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28726
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MESRISPTEALRGSIRYWNDFISKCLTKRLDAGPFEDYVKLVFAKHQLTPDIIADFFLQPQKSNCVSPDPRIPPYISVLTQLRYVDAASILRALYRYSSLHSLIPQQAQEQGKELGQDQEQDEGGIQLDGETKKDGTQPSQTRWKSSSWLEEVMFYHVIRLVVEGTALKDSRTALELMHIISKWMSLFSAASNSMAADMLAGGLQDPQVRHEMEVSRAAFVPLLLRLVDNPALVKAISHPAGKEPRKNFSESLTSFVQIFQPVPQFVEKLEIFRTEVLAPLDPVDKNNQAANAAMDELLDSTVGLDSLVISDLPITNTRAGLYIYLGASLVGRPLIDDHALFSYLNNRYQGNTQQSAIDLILASFDLLANAVFRNEGPRDAHLLRSFLINKVPLILGQICPPGFATSAEFCITEALSQVDTSVFPTASLMFDESRNNNPYTESVREEFCSACALHGLIEREHVERILGESSMSYEPSQEKYSKEKLVQSCLSDPDKIQALIRDMDKMDGNVGAVCQALVELLRQLCNSKETMSLKILCSQLVQKPQSLDVLLLFEKLPTVLEPICQLLDGWRYDEDQGEYQPVYEEFGAILLLVLAFAYRYGLSPADIGILSADSNVAKIIGRAHISLNLDQLTEQEHGHLGGWIHGLFDSDAGGLGDDLMSSCPPAEFYLLIATLFENIVIAYSQGSLTDDALRSGIEYLVDTFLLPSLIPAIRFLSEYLWVEQREQKSIIKILQLILLPTSISGEASTMLTAVKGIVAKPLEHSLRAYQRQDPKNQDIEPLLRALKDSLPTSRRTGAAEHQELETWATSSSSGLSGATKHLIQALVQWCIHPEMTAMPTSYTHRQIIATLKIVGASRLLRVMLEEIRQQMLTGSGSVVYDVVTALVCAPNVSNDLPPTSGLLDEAGNMPPPLQRRLTLREVLKMEAEDYRKLHKKDAELAEIVVRLYRRVEAQMVLPPPPMLQAADMQLDLAGDAASLVGDSMAAAAGVPGDGTLSIDGVGGLDMGIGGVTSDLGLGAAGSNGGLDASAEADLFGSLDTDMDVFDGWGGMDLGGP |
Length | 1057 |
Position | Tail |
Organism | Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens) (Trichoderma virens) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.063 |
Instability index | 44.57 |
Isoelectric point | 4.84 |
Molecular weight | 116104.35 |
Publications | PubMed=21501500
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP28726
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 98.31| 32| 35| 975| 1009| 1
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975- 1009 (52.53/40.37) GDAASLVGdsmAAAAGVPG..DGTLSIDGVGGLD..MGI
1010- 1045 (45.78/26.85) GGVTSDLG...LGAAGSNGglDASAEADLFGSLDtdMDV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 142.22| 45| 48| 477| 523| 2
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477- 523 (66.15/47.55) SQEKYSKEKLVQSCLSDPDKIQALIRdMDKMDGNVGAVCQaLVELLR
528- 572 (76.07/45.88) SKETMSLKILCSQLVQKPQSLDVLLL.FEKLPTVLEPICQ.LLDGWR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 35.10| 10| 31| 654| 663| 3
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654- 663 (18.25/ 9.49) GGLGDDLMSS
687- 696 (16.84/ 8.18) GSLTDDALRS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.08| 10| 34| 802| 811| 9
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802- 811 (18.84/11.68) HQELETWATS
833- 842 (19.24/12.08) HPEMTAMPTS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.16| 18| 72| 207| 238| 13
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207- 224 (30.94/39.90) P...QVRHEMEVSRAAFVPLL
240- 260 (26.23/ 6.64) PagkEPRKNFSESLTSFVQIF
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