<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28723

Description Uncharacterized protein
SequenceMNSGGKESLSLDERSRNVNDLLLVLMDINEINGGNSDTAEKMKVHAKNFEAALYAKSSSKKEYMDSMREKVNAMRNTRDSRKKAAVSAATPLSAGSVNRSMQQNGQQQRQGNMMMNGNYVPNTLNMNSQTFMNQQAQARQQAAQQLRTQQQQQQQRPQLTPQQQQLINQMKVAIIPRELLQRIPNIPPGVNTWQQITDLAQQKRLTPQDMQMAKEVYKLHQQLLYKSKIQQQQQQNANGRMNMQQQMPQQPPSRGAPSAQHQRAPSNGPLSQHHHSSSLNRPAQQQPQQQQRQLKPGEIPNVLGQINQIFTPEEQRSLLQEAMEACKNFQKTQFGKNMTDSNRQNFIRKYINQKALKKIQNMRLAQMAANGTSQRPQQRQEPISQMQQAHSRSASAGLMPNGNQFNGNTNPQPTGPQQPVPGQQMNMGSQPPQQQPQQGKMQQPRPNVLQAFAPTPQDVETVKRISVEAARTPLRLSDLTNTLPPQEKEEIKRKLQVNQQLFAQVSNYAPQVYVLTKSENFLKEVLQLRIFVKEIVEKCTKGIFVVKLDTVDKLVLKYQKYWESMKIQLLRRQQLIQQQQQQQQQQQQQHFNQDQTGPSISEQQQRVQGSLQQIQQQMQQKQRQQQQRSAPNSSSAMATPNPAAMAAATAMSNGNNYAGSNYQPVMTEANGATDLKNGGANIGYMAPDTTKPSPSQGISPQKAANHSRIKSSSTKVSPANIGQSGINTPSVAAPGMVNSRSATPAAAGTAGSPLGNVKNSAIFQKSPSPMTVPSTRQTPLVENKPFRQEEDNLRNLNIRKAEIISRFKHRQEVFHSSPIDMFLSTLADCIGIKDDQVDIVTHVPQAVIDQINGTGKKKPTKATQRARDQDVVTLAFKDNKFIMESKTSPKTRSYRIRPNALSSVFKNVYGTTDIGEMNFNDATPKRISGGSQVIGRKRKLDESGISPVDSVTSQSSSLMGDSKKVKIDSPEDLFAGKENIKLQKPLQESLNNIWDWNYWQKLD
Length1003
PositionTail
OrganismTorulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Torulaspora.
Aromaticity0.04
Grand average of hydropathy-0.916
Instability index57.80
Isoelectric point10.05
Molecular weight112429.66
Publications
PubMed=22123960

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
RNA polymerase II activating transcription factor binding	GO:0001102	IEA:EnsemblFungi
TFIIE-class transcription factor complex binding	GO:0001095	IEA:EnsemblFungi
TFIIH-class transcription factor complex binding	GO:0001097	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of invasive growth in response to glucose limitation	GO:2000219	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
regulation of establishment of protein localization to chromosome	GO:0070202	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28723
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     257.40|      34|      35|     568|     601|       1
---------------------------------------------------------------------------
  135-  177 (40.79/10.48)	QAQARQ...Q..AAQQlrtQQQQQQQrpqltpQQQ.....QLIN...QM.KVAIIPR
  269-  303 (35.99/ 8.31)	PLSQHH...HssSLNR...PAQQQPQ......QQQ.....RQLK...PG.EI.PNVL
  360-  393 (43.19/11.56)	QNMRLA...Q..MAAN...GTSQRPQ......QRQ.....EPIS...QM.QQAHSRS
  424-  466 (32.10/ 6.55)	QMNMGS...Q..PPQQ...QPQQGKM......QQPrpnvlQAFAptpQDvETVKRIS
  568-  601 (63.53/20.77)	QLLRRQ...Q..LIQQ...QQQQQQQ......QQQ.....QHFN...QD.QTGPSIS
  603-  634 (41.80/10.93)	QQQRVQgslQ..QIQQ...QMQQKQR......QQQ.....Q.........RSAPNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.61|      29|     450|     238|     266|       2
---------------------------------------------------------------------------
  232-  260 (49.70/22.47)	QQQQNANGRMNMQQQMPQ...QPPSRGAPSAQ
  655-  676 (30.43/10.81)	NNYAGSN......YQ.PV...MTEANGATDLK
  706-  737 (32.49/12.06)	HSRIKSSSTKVSPANIGQsgiNTPSVAAPGMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.57|      18|      24|     740|     763|       4
---------------------------------------------------------------------------
  740-  759 (26.03/24.76)	RSATP.AAAGTAGSPLgnVKN
  765-  783 (28.53/10.19)	KSPSPmTVPSTRQTPL..VEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.55|      22|      24|      40|      61|       5
---------------------------------------------------------------------------
   40-   61 (34.55/23.78)	EKMKVHAKNFEAALYAKSSSKK
   62-   83 (37.00/25.99)	EYMDSMREKVNAMRNTRDSRKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.78|      32|     294|     180|     219|       7
---------------------------------------------------------------------------
  178-  217 (47.88/33.30)	ELLQRIpnippgvnTWQQITDLAQQKRLTPQDMQMAKEVY
  472-  495 (32.00/ 9.43)	..............TPLRLSDLT..NTLPPQEKEEIKRKL
  496-  513 (30.89/10.58)	QVNQQL...............FAQVSNYAPQ.......VY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.47|      28|     208|      95|     134|       8
---------------------------------------------------------------------------
   90-  117 (50.04/20.70)	TPLSAGS.VNRSMQ..QNGQQQRQGNMMMNG
  311-  341 (39.43/12.99)	TPEEQRSlLQEAMEacKNFQKTQFGKNMTDS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28723 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKSSSKKEYMDSMREKVNAMRNTRDSRKKAAVSAATPLSAGSVNRSMQQNGQQQRQGNMMMNGNYVPNTLNMNSQTFMNQQAQARQQAAQQLRTQQQQQQQRPQLTPQQQQLIN
2) QQQQQQQQQHFNQDQTGPSISEQQQRVQGSLQQIQQQMQQKQRQQQQRSAPNSSSAMATPNPAAMAAATAMSNGNNYAGSNYQPVMTEANGATDLKNGGANIGYMAPDTTKPSPSQGISPQKAANHSRIKSSSTKVSPANIGQSGINTPSVAAPGMVNSRSATPAAAGTAGSPLGNVKNSAIFQKSPSPMTVPSTRQTPLVENKPFRQEEDNLRN
3) RELLQRIPNIPPGVNTWQQITDLAQQKRLTPQDMQMA
4) SKIQQQQQQNANGRMNMQQQMPQQPPSRGAPSAQHQRAPSNGPLSQHHHSSSLNRPAQQQPQQQQRQLKPGEIPNVLGQINQIFTPEEQRSLLQEAMEACKNFQKTQFGKNMTDSNRQNFIRKYINQKALKKIQNMRLAQMAANGTSQRPQQRQEPISQMQQAHSRSASAGLMPNGNQFNGNTNPQPTGPQQPVPGQQMNMGSQPPQQQPQQGKMQQPRPNVLQAFAPT
55
581
177
227
168
795
213
455










Molecular Recognition Features






MoRF SequenceStartStop




1) FIRKYIN
346
352