<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28719

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMEGESVYKLALRCAEREIASADFLNLYKEFYNEKVSANVENDDSPEEKSKITEVCNRLATDLLQLLNSQRQLLLADYVAEVLFVNYNSELVNAVLPQIYSVDNPTMLLHFFSQSCAFFAKLSDSLIADDISKDAPKCIIPSVLNADPQRMDDTLIVAVCKFLQFVLKNVSGSITIESDSLRESCYALMSRLSKLNKLLHRKVSQTIDSKIEFKNAKNNLTKDSVQEYGSSPSISSPQFIASPFSTSKVPSSKASTVKYQDMKLLRFYKNIWLNNKIKNWEPIDAGFLSRYASIAPSIFQDATIPFPTVDAQLTDLIETSFTCFAQFVSNKQYHQSNSNLNLLERQWIIFIVTQIPLLILENSTGNSQVITNALGSLDDKVVKAIRTYYSEKDDAKNRNEDLFDDYPSASLDIRHEFIKSLVKLGLQPATAINEYLREDQVIDTKSLPVRDDLTVNNSQGGEEVITDIKQFVSSSLDSLEPELVGIQSNEHIDGLQQVLRNFENVPPTKQKVLSHVFVELLEEATNKFDFNRIGKICLLLSFNFSHSLTAILTFMTPVRICEILMKFIDVLWDGCVEVKRKELADSEFETMNMFSSFTWSLLMLIVISQNYDISLIDVALQSSELTTESSFTIPFVSKLPEIPDIYFKDQTKAVDPNMHTESHQMVENWLRDLFVNGSISDSLLQSVDTKQLASLIPFIFKQILLALEVEAIDDISNLVGGFEYFLQPFMLIGLIKIVYWLEQYLYSLRSDMINESLLEKVFTLLNTIFNPTSLNEDSRSFHSAVLRLNAVRLLRVLRKFRVQSQSNYGIYSSEASGHPKLESLIKSFTTVLQVSPNYNLDPRDINSENAFSQKQLGYGSMLILNENPINKIMTNQINSFWNLHSSTYYNLDYLEEIIDLVTPRNFLIDVFRTLEYKLSTYGVPGVRNKMSPAESEHVLNYLFYFLALYDVKSQDDATKLLSLMEKSEIPSTAKEAQLKSEPAPKQEAMPDDDFDMLFGENDTSTHGGDEEVQVTNVERNCKFNGTAAYHRGSFGLLLHELKVDYDSALAARDITKEARDKLDRYHEKYIHMLRTCVF
Length1077
PositionTail
OrganismTorulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Torulaspora.
Aromaticity0.10
Grand average of hydropathy-0.174
Instability index43.89
Isoelectric point4.99
Molecular weight122620.12
Publications
PubMed=22123960

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
histone H3 acetylation	GO:0043966	IEA:EnsemblFungi
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblFungi
transcription by RNA polymerase II	GO:0006366	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28719
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     615.11|     202|     230|     431|     658|       3
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  427-  543 (113.26/78.95)	......................................................................................................................PATA......INEYLReDQVIDTKslpVRDDL..TVNNSQGGEEVITDI..KQFVSSSLDSLEPELVGIQSNEHIDGLQQVLRNFENVPPTK.....QKVLSHVFVELLEEATnkfdfnrIGKICLLLSFNF
  544-  768 (275.26/193.12)	SHSLTAILTFMTPVRICEILMKFiDVLWDGCVEVKRKElADSEFETMNMFSSFTwSLLMlivISQNYDislidvaLQSSELTTESSFT...IPFVSKL....PEIPDIyFKDQTKAVdPNMHteshqmVENWLR.DLFVNGS...ISDSLlqSVDTKQLASLIPFIF..KQI....LLALEVEAIDDISN.LVGGFEYFLQPFMLIGLIKivywlEQYLYSLRSDMINESL.......LEKVFTLLNTIF
  777-  942 (226.59/125.78)	SRSFHSAVLRLNAVRLLRVLRKF.RVQSQSNYGIYSSE.ASGHPKLESLIKSFT.TVLQ...VSPNYN.......LDPRDINSENAFSqkqLGYGSMLilneNPINKI.MTNQINSF.WNLH............................ssTYYNLDYLEEIIDLVtpRNFLIDVFRTLEYKL....STYGVPG....VRN.KMSPAES.....EHVLNYLF...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.90|      24|      43|      94|     117|       5
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   94-  117 (43.12/24.54)	VLPQIYSVDNPTMLLHFFSQSCAF
  138-  161 (40.79/22.88)	IIPSVLNADPQRMDDTLIVAVCKF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.22|      29|      53|       9|      37|       7
---------------------------------------------------------------------------
    9-   37 (48.22/34.76)	LALRCAEREIASADFLN..LYKEFYNEKVSA
   63-   93 (42.00/29.21)	LQLLNSQRQLLLADYVAevLFVNYNSELVNA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28719 with Med5 domain of Kingdom Fungi
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