<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28714

Description Uncharacterized protein
SequenceMSGISDLLVPDMKLEELETSLATGGDDPKDRVDKAITDAQNSILPMRLQFNDFMHTMSNIDDLQNSTPMEKFNLIRSKVLDLSDKLQTMSEDVGKLHPLFDTIPEYSEKYGTKKFQPLETLRIPQSNSVSSPQTQNNAIVGANLNKKANRSNDGTPVSQTSTPMGSAVPTPYATTAKKPRKPRQPKKPQTPAAAAAAAAVAANGHIKSQASPTPPAHMVSSVPATNPVQMVNSVPPTNMMGTPMQNLMSPLGNTPNYGFSQQQSQQQPTPQQQQRQQYNSATKNSTMPQSQPMNLNSITPANILSMSMTGDPLHQQQQQNKKEFDPLDFNNLDFGNLNMDMI
Length342
PositionTail
OrganismTorulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Torulaspora.
Aromaticity0.04
Grand average of hydropathy-0.733
Instability index55.27
Isoelectric point6.98
Molecular weight37404.74
Publications
PubMed=22123960

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
RNA polymerase II activating transcription factor binding	GO:0001102	IEA:EnsemblFungi
RNA polymerase II core promoter sequence-specific DNA binding	GO:0000979	IEA:EnsemblFungi
RNA polymerase II repressing transcription factor binding	GO:0001103	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28714
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     216.88|      54|      55|     209|     263|       1
---------------------------------------------------------------------------
  123-  178 (39.44/12.46)	......................IPQSNSV....SSPQTQNNaivganlnkkanrsndGTPVSQTSTPMGSavpTP.YATTAKK
  209-  263 (101.06/44.95)	QASPTP.........PAHMVSSVPATNPVQMvNSVPPTNMM................GTPMQNLMSPLGN...TPNYGFSQQQ
  265-  319 (76.37/30.23)	QQQPTPqqqqrqqynSATKNSTMPQSQPMNL.NSITPANIL................S......MSMTGD....PLHQ.QQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.75|      16|      16|      84|      99|       2
---------------------------------------------------------------------------
   84-   99 (28.99/20.05)	DKLQTMSEDVG..KLHPL
  101-  118 (25.76/17.06)	DTIPEYSEKYGtkKFQPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28714 with Med3 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KKFQPLETLRIPQSNSVSSPQTQNNAIVGANLNKKANRSNDGTPVSQTSTPMGSAVPTPYATTAKKPRKPRQPKKPQTPAAAAAAAAVAANGHIKSQASPTPPAHMVSSVPATNPVQMVNSVPPTNMMGTPMQNLMSPLGNTPNYGFSQQQSQQQPTPQQQQRQQYNSATKNSTMPQSQPMNLNSITPANILSMSMTGDPLHQQQQQNKKEFDPLDFNNLDFGN
113
336










Molecular Recognition Features






MoRF SequenceStartStop




1) AAAAAAV
2) KKPRKPRQPKKP
194
177
200
188