<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28706

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTTELDLEKMLDGKGATGNVGTKEMPKNDELDGVIPNGKRTNSKDIQVLQTPDSNARRVADPAVTPPPIPHVEINQVSLALIMRNLTVFTMKEISQYMKTNEHVNPQEPGSARKLRFLQLIIFMRNQFLKLYVLIKWCRTIKNNNFHTMIDLLNWFRVANAQVNNCIWALKSNVTAMSNAKLPNADLVTALEVLSLGRTNLPVHNFRMSGEDDPEAVAGGMKKIPPKLVLHRLRDLNLAVSLKIALIDFPPQFQNYVIKNGRIYITVAEEFEIQLATIDCHSPLFFVDLQFLFTDRNLPLNKLRTEKVINELLFKSAKPLLALHNFLHKYVLTLQLYMIHSELLDMESGGKFTGGNLVHRYDSKKSVISIKYWIHSKLGRRAKITIGVEKSTESLVLKWNNPIATQSRMPVRYTNILKNLESILDEIMFNHSYLIRADLLAKGVFQEDEESPDVLLFQVPTTCFSVAPIQLKIDLLSGVFYFKNPTALLLKYVSQINRAENAEDLTKVLHRLKLEKISHILRNMFEKTGWMCSRVIKLDQPIESQTATKNSSNALLQDDIFIRLPNWLANWYLILTVISSNTSCIVEKRIGKVASVKGKWQLVYLGKSTVTTSRLETMTYQKVLHLQKTIFHRVVNHMIIDSLNQLNIRNKICANDLASSTLPHYIADDSIANSNGECYTSIITLELESFLEGSKALNSILESSMFMKIDYSRSEIKLFGKFKCDTAMIKCKCDELLIHFVPDDALAFYLCEELTNLNFIGQYLTKFKQKLMQMVVLTDVVERLHRNFASEGFKIVALKPNEISFKYLKDSTDNQDCTISIITSDQTVENMTVQLSPSNPQHIIQPFIDKGHMDYHSIFNYLQFTSSLFIVFKTILSENQNSTNSYTMVSLGLHNLCEYQLLYHNPESGTKITVIVELKNVSHNRRKKIQFYIHFSDEEHVSTKSMAYPLVHQVRNQVFMLETRDNSVATGPRKYPHAIKLVDGISCDPSDVGPILLEIHNILRTDSNVVGSTPAMNGISSINPTTIPATATTL
Length1034
PositionTail
OrganismTorulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Torulaspora.
Aromaticity0.08
Grand average of hydropathy-0.120
Instability index34.42
Isoelectric point8.76
Molecular weight117612.02
Publications
PubMed=22123960

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
RNA polymerase II repressing transcription factor binding	GO:0001103	IEA:EnsemblFungi
TFIIB-class transcription factor binding	GO:0001093	IEA:EnsemblFungi
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28706
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.20|      23|     193|     738|     760|       1
---------------------------------------------------------------------------
  738-  760 (41.96/22.41)	IHF.....VPDDALAFYLCEELTNLNFI
  933-  960 (36.24/18.54)	IHFsdeehVSTKSMAYPLVHQVRNQVFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.69|      52|      95|     191|     249|       3
---------------------------------------------------------------------------
  191-  249 (77.63/64.20)	LEVLSLGRtNLPVHNFRmsgeddPEAVAGGM..KKIPPKLVLHR.LRDLNLAVSLKI...ALIDF
  289-  346 (74.06/44.71)	LQFLFTDR.NLPLNKLR......TEKVINELlfKSAKPLLALHNfLHKYVLTLQLYMihsELLDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.96|      19|     504|     147|     165|       4
---------------------------------------------------------------------------
  147-  165 (33.67/17.91)	HTMIDLLNWFRVANAQVNN
  637-  655 (30.43/15.57)	HMIIDSLNQLNIRNKICAN
  660-  675 (18.86/ 7.24)	STLPHYIADDSIANSN...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.81|      57|     283|     504|     562|       7
---------------------------------------------------------------------------
  504-  562 (90.06/61.93)	DLTKVLHR...........LKLEKIS.HILRNMFEKTGwmC.S.RVIKLDQPIESQTATKNSSNA..LLQDDIFI
  678-  706 (21.48/ 7.11)	........................................CyT.SIITLE..LESFLEGSKALNS..ILESSMF.
  779-  848 (74.27/43.74)	DVVERLHRnfasegfkivaLKPNEISfKYLKDSTDNQD..C.TiSIITSDQTVENMTVQLSPSNPqhIIQP..FI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.48|      46|     397|      50|      96|       9
---------------------------------------------------------------------------
   50-   96 (73.64/53.19)	QTPDSNARRVADPAVTPPPIpHVEINQVSLALIMRNLTVFTMKEISQ
  450-  495 (77.85/51.08)	ESPDVLLFQVPTTCFSVAPI.QLKIDLLSGVFYFKNPTALLLKYVSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28706 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTTELDLEKMLDGKGATGNVGTKEMPKNDELDGVIPNGKRTNSKDIQVLQTPDSNARRVADPAVT
1
65










Molecular Recognition Features






MoRF SequenceStartStop




NANANA